Impact of surgical timing on survival in patients with infective endocarditis: a time-dependent analysis

Ripa, Marco; Chiappetta, Stefania; Castiglioni, Barbara; Agricola, Eustachio; Busnardo, Elena; Carletti, Silvia; Castiglioni, Alessandro; Bonis, Michele De; Canna, Giovanni La; Oltolini, Chiara; Pajoro, Ursola; Pasciuta, Renée; Din, Chiara Tassan; Scarpellini, Paolo; Team, Ospedale San Raffaele Endocarditis

doi:10.1007/s10096-020-04133-x

Cited by 1 publication

(2 citation statements)

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“…Third, the use of fluid is a time-varying exposure that can cause bias in the current results. The marginal cox model, time-dependent propensity score methods and other time-varying models might help in resolving this problem ( Zhang et al, 2018 ; Zhang et al, 2020 ; Ripa et al, 2021 ). However, these models only account for time-varying exposure in the exposure group since the study design of these studies actually had no exposure in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…To address the linearity relationship between the categorical outcomes and covariates, binary logistic regression by the Box–Tidwell method was conducted ( Cheng et al, 2021 ). Collinearity diagnostic analysis was done to clarify the potential multi-collinearity between covariates by evaluating the tolerance and variance inflation factor (VIF) value ( Ripa et al, 2021 ). In the repeated measurement data analysis, we used two-way ANOVA for comparison between the groups as well as to detect change with time.…”

Section: Methodsmentioning

confidence: 99%

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The Efficacy and Safety of Sodium Bicarbonate Ringer’s Solution in Critically Ill Patients: A Retrospective Cohort Study

Bian

et al. 2022

Front. Pharmacol.

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Background: Sodium bicarbonate Ringer’s solution has been widely used in clinical practice in recent years. There are few clinical studies on the efficacy and safety of this fluid among critically ill patients until now.Method: This retrospective cohort study included critically ill adult patients in the intensive care unit (ICU) of Tongji Hospital from 1 January 2019 to 31 December 2020. By reviewing exclusively the use of either sodium bicarbonate Ringer’s solution or saline for resuscitation or maintenance, the patients were included into two groups, respectively. The primary outcome was the major adverse kidney event within 30 days (MAKE30), including death, new receipt of renal replacement therapy, or persistent renal dysfunction. Safety outcomes were focused on arterial blood gas and plasma biochemical alterations, which might potentially be induced by the administration of bicarbonate Ringer’s solution.Result: A total of 662 patients were included in the cohort. Compared to the saline group, the bicarbonate Ringer’s group had a significantly lower rate of the new receipt of renal replacement therapy [adjusted odds ratio (OR) = 0.591, 95% confidence interval (CI), 0.406 to 0.861; p = 0.006]. There was no significant difference between the two groups in 30-day mortality, final creatinine level ≥200% of baseline, and major adverse kidney event within 30 days. In subgroup analysis, the incidence of MAKE30 was higher in the bicarbonate Ringer’s group than that of the saline group among patients with cardiovascular disease. The patients in the bicarbonate Ringer’s group had a longer length of intensive care unit stay than patients in the saline group, but their new renal replacement therapy days were shorter. No major alterations were found in arterial blood gas and plasma biochemical during the follow-up period.Conclusion: Compared to saline, sodium bicarbonate Ringer’s solution exhibited a potential renal function protective effect while causing no major alterations in arterial blood gas and plasma biochemistry. However, the application in patients with cardiovascular disease diagnosis at ICU admission should be cautious.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%