Impact of System Factors on the Performance of Photoacoustic Tomography Scanners

Tian, Chao; Pei, Mengliu; Shen, Kang; Liu, Songde; Hu, Zhiming; Tian, Feng

doi:10.1103/physrevapplied.13.014001

Cited by 72 publications

(50 citation statements)

References 33 publications

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“…First, 10 sets of the acquired RF data are averaged and then preprocessed with a digital bandpass filter (2-10 MHz) to reduce noise. Owing to the fact that the transducer's elements can only be vibrated by the cosine part of the wave vector in the normal direction of the elements [32], the element directivity is compensated by a cosine-weighting factor. It weights the received PA signals according to the acoustic energy projected on the element's normal direction.…”

Section: Methodsmentioning

confidence: 99%

Spherical‐matching hyperbolic‐array photoacoustic computed tomography

Duan

Cheng

Qiu

et al. 2021

Journal of Biophotonics

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Linear‐array photoacoustic computed tomography (LA‐PACT), for its flexibility and simplicity, has great potential in providing anatomical and functional information of tissues. However, the limited coverage view impedes the LA‐PACT obtaining high‐quality images. In this study, a photoacoustic tomographic system with a hyperbolic‐array transducer was developed for stereoscopic PA imaging of carotid artery. The hyperbolic‐array PACT increases the receiving sensitivity for PA signal detection due to its transducer's geometric structure matching with the spherical wave. The control phantom experiment shows that the proposed system can expand the angular coverage of ∼1/3 more than that of the LA‐PACT system, and the volumetric PA images of rat's carotid artery demonstrates the potential of the system for carotid artery imaging. Furthermore, volumetric imaging of the human forearm verifies that the system has significant capability in human imaging, which indicates that it has bright prospect for assisting diagnosis in the vascular disease.

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Section: Methodsmentioning

confidence: 99%

Spherical‐matching hyperbolic‐array photoacoustic computed tomography

Duan

Cheng

Qiu

et al. 2021

Journal of Biophotonics

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“…Biomedical photoacoustic (PA) technologies have drawn considerable attention in the last decades, and have been explored extensively for many preclinical and clinical applications [ [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] ]. In prior studies, the method of detecting backscattered PA signals has been explored for assessing ex vivo bone structure and density [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo

et al. 2021

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The photoacoustic (PA) technique is uniquely positioned for biomedical applications primarily due to its ability to visualize optical absorption contrast in deep tissue at ultrasound resolution. In this work, via both three-dimensional (3D) numerical simulations and in vivo experiments on human subjects, we investigated the possibility of PA measurement of human calcaneus bones in vivo in a non-invasive manner, as well as its feasibility to differentiate osteoporosis patients from normal subjects. The results from the simulations and the experiments both demonstrated that, when one side of the heel is illuminated by laser with light fluence under the ANSI safety limit, the PA signal generated in the human calcaneus bone can be detected by an ultrasonic transducer at the other side of the heel (i.e. transmission mode). Quantitative power spectral analyses of the calcaneus bone PA signals were also conducted, demonstrating that the microarchitectural changes in calcaneus bone due to osteoporosis can be detected, as reflected by enhanced high frequency components in detected PA bone signal. Further statistical analysis of the experimental results from 10 osteoporosis patients and 10 healthy volunteers showed that the weighted frequency as a quantified PA spectral parameter can differentiate the two subject groups with statistical significance.

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“…In PAI, the chromogenic group in tissue is illuminated by a short-pulse laser, and then the laser-induced pressure waves are detected by ultrasound transducers to reconstruct an image, which reveals the distribution of the optical absorbers at the region of interest (ROI) [4][5][6]. This hybrid imaging approach combines the advantages of conventional optical imaging with those of acoustic imaging, allowing for both molecular contrast and high spatial resolution in deep tissue [1,[7][8][9]. As for other medical imaging techniques: X-ray Imaging involves ionizing radiation and non-optimal sensitivity as well *Yongjian Zhao and Li Liu contribute equally in this work.…”

Section: Introductionmentioning

confidence: 99%

Design of Continuously-Adjustable Light-Scanning Handheld Probe for Photoacoustic Imaging

Zhao

Liu

et al. 2021

IEEE Photonics J.

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To form various images at multiple locations for achieving bright-and dark-illumination fields transformation and registration-free image fusion, we proposed a continuouslyadjustable light-scanning handheld probe with overall size of 60 × 45 × 80 mm 3 for photoacoustic imaging (PAI). It has a significant advantage for image acquisition under different illumination schemes using motor driving. Specifically, a light adjustment unit was designed to produce light spots, which is more compatible with ultrasonic transducer detection region. Afterwards, multiple PA images revealing diverse features with different optical illumination regions were acquired. Consequently, the fused image was obtained with higher SNR and fidelity than respective PA image. Furthermore, both phantom and ex-vivo experiments were conducted to evaluate imaging performance of the developed probe. Experimental results show that SNR of the fused PA image improves by 36.06% in agar-milk phantom and 44.69% in ex-vivo chicken breast, respectively. Therefore, the proposed PAI handheld probe can achieve our goals well; the registration-free image fusion achieved by adaptive scanning strategy can perform better and demonstrate comprehensive features of the same imaging target.

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Impact of System Factors on the Performance of Photoacoustic Tomography Scanners

Cited by 72 publications

References 33 publications

Spherical‐matching hyperbolic‐array photoacoustic computed tomography

Spherical‐matching hyperbolic‐array photoacoustic computed tomography

The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo

Design of Continuously-Adjustable Light-Scanning Handheld Probe for Photoacoustic Imaging

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