Impact of systemic sclerosis oral manifestations on patients’ health‐related quality of life: A systematic review

Smirani, Rawen; Truchetet, Marie-Élise; Poursac, Nicolas; Naveau, Adrien; Schaeverbeke, Thierry; Devillard, Raphaël

doi:10.1111/jop.12739

Cited by 27 publications

(33 citation statements)

References 47 publications

(148 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Approximately 90% of patients with SSc have a variety of orofacial features such as the fibrosis of the facial skin, microstomia, salivary gland dysfunction and xerostomia, dysphagia as well as an increased risk of dental caries and periodontal disease 4 . A recent systematic review has demonstrated a correlation between orofacial features of SSc and impaired quality of life of patients with SSc 5 …”

Section: Introductionmentioning

confidence: 99%

Validity and reliability of the Mouth Handicap of Systemic Sclerosis questionnaire in a UK population

Abdouh

Porter

Fedele

et al. 2020

J Oral Pathology Medicine

View full text Add to dashboard Cite

Background The objective of this study was to explore the psychometric properties of the Mouth Handicap in Systemic Sclerosis (MHISS) specifically exploring aspects of validity and reliability of MHISS in UK SSc patients. Methods A total of 150 questionnaires were distributed in this study at the Oral Medicine Department of UCLHT Eastman Dental Hospital, the Outpatient Rheumatology Clinic of the Royal Free Hospital and Scleroderma Family Day. Participants were asked to complete three questionnaires (SF‐36, OHIP‐14 and MHISS) along with a pro forma of demographic and disease‐specific questions. Both convergent validity and internal consistency reliability were examined. The convergent validity was assessed by Spearman's correlation coefficient, and internal consistency reliability was assessed by Cronbach's alpha. Results Of the 150 questionnaires distributed to participants, 68 respondents were included. With regard to construct validity, a low to moderate degree of convergent validity was found between MHISS total score and all SF‐36 subscales. However, the total MHISS score was highly correlated to all OHIP subscales. Conclusion MHISS questionnaire is a self‐administered patient‐reported outcome measure that assesses the mouth disability in SSc patients. However, improving the global and oral health of SSc patients is important as there is no cure for the disease; thus, instruments that record the impact of the condition and indicate the effect of treatment on the lives of patients are of paramount importance. Current results demonstrate good preliminary psychometric properties (validity and reliability) in a UK population with further exploration of psychometric properties with an emphasis on interpretability required.

show abstract

Section: Introductionmentioning

confidence: 99%

Validity and reliability of the Mouth Handicap of Systemic Sclerosis questionnaire in a UK population

Abdouh

Porter

Fedele

et al. 2020

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Dysbiosis of the oral microbiome [3][4][5][6] and host responses influenced by many factors are involved in the pathogenesis of periodontitis [7][8][9][10][11]. Further, presence of systemic diseases [12,13] and gene polymorphisms [14][15][16] are reportedly correlated with the risk for periodontitis. Degradation of extracellular matrix (ECM) within the gingival connective tissue located between tooth and alveolar bone is the driving force in the pathological process of periodontitis [9,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Targeting hepatocyte growth factor in epithelial–stromal interactions in an in vitro experimental model of human periodontitis

et al. 2021

View full text Add to dashboard Cite

Periodontitis is a chronic inflammatory disease leading to progressive connective tissue degradation and loss of the tooth-supporting bone. Clinical and experimental studies suggest that hepatocyte growth factor (HGF) is involved in the dysregulated fibroblast–epithelial cell interactions in periodontitis. The aim of this study was to explore effects of HGF to impact fibroblast-induced collagen degradation. A patient-derived experimental cell culture model of periodontitis was applied. Primary human epithelial cells and fibroblasts isolated from periodontitis-affected gingiva were co-cultured in a three-dimensional collagen gel. The effects of HGF neutralizing antibody on collagen gel degradation were tested and transcriptome analyses were performed. HGF neutralizing antibody attenuated collagen degradation and elicited expression changes of genes related to extracellular matrix (ECM) and cell adhesion, indicating that HGF signaling inhibition leads to extensive impact on cell–cell and cell–ECM interactions. Our study highlights a potential role of HGF in periodontitis. Antagonizing HGF signaling by a neutralizing antibody may represent a novel approach for periodontitis treatment.

show abstract

“…However, because of the rarity of SSc, large-scale studies and quantitative analysis were still needed. [5] The biological plausibility for the association between SSc and oral disorders has been revealed by studies [6]. Additionally, multiple comparative studies have been conducted to investigate the possible links between SSc and oral manifestations, however, the ndings were inconsistent [3,[7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Oral Manifestations of Patients with Systemic Sclerosis: A Meta-analysis for Case-controlled Studies.

Zhang

Zhu

et al. 2021

Preprint

View full text Add to dashboard Cite

Background：Systemic sclerosis (SSc) is a multisystem rheumatic disease. Orofacial manifestations are commonly in SSc but maybe usually ignored and overshadowed by other systemic complications. Multiple comparative studies have been conducted to investigate the possible links between SSc and oral manifestations. The present study aimed to investigate the oral health status in patients with SSc. Methods：Pubmed, Embase, Web of Science, and Scopus were searched up to July 2020. Following outcomes were evaluated: Probing depth (PD), Attachment loss (AL), Bleeding on probing (BOP), Number or percentage of Sites with PD ≥ 4 mm, Prevalence of periodontitis, Number of teeth, Decayed Teeth, Missing teeth, Filled teeth, DMFT index, and the interincisal distance. Newcastle-Ottawa Scale (NOS) were applied for quality assessment. The statistical analysis was processed using the software STATA.Results: 11 eligible studies were included. The maximum interincisor distance was significantly restricted in SSc patients (SMD -1.061; 95%CI [-1.546, -0.576]; Z=4.29, P=0.000).The prevalence of Periodontitis (OR 7.007; 95%CI [3.529,13.915]; Z=5.56, P=0.000) , PD (SMD 3.101; 95%CI [1.374, 4.829]; Z=3.52, P=0.000), AL(SMD 2.584; 95%CI [0.321, 4.846]; Z=2.24, P=0.025) , sites with PD≥4mm (SMD 2.071 ; 95%CI [0.267, 3.875]; Z=2.25, P=0.024) and the number of decayed teeth (SMD, 0.186; 95%CI [0.007, 0.365]; Z= 2.04, P=0.041) were increased significantly in SSc population in comparison with the controls. Conclusions: SSc patients have limited mouth opening, higher periodontitis prevalence, and worse periodontal status, as well as an increased number of decayed teeth. Routinely oral hygiene instruction and initial periodontal treatment is recommended for SSc patients.

show abstract

Impact of systemic sclerosis oral manifestations on patients’ health‐related quality of life: A systematic review

Abstract: This systematic review demonstrates a correlation between oropharyngeal manifestations of systemic sclerosis and impaired quality of life, despite the low level of evidence of included studies. Large-scaled studies are needed to provide stronger evidence of this association.

Cited by 27 publications

References 47 publications

Validity and reliability of the Mouth Handicap of Systemic Sclerosis questionnaire in a UK population

Validity and reliability of the Mouth Handicap of Systemic Sclerosis questionnaire in a UK population

Targeting hepatocyte growth factor in epithelial–stromal interactions in an in vitro experimental model of human periodontitis

Oral Manifestations of Patients with Systemic Sclerosis: A Meta-analysis for Case-controlled Studies.

Contact Info

Product

Resources

About