Infections of the bloodstream that is caused by vascular catheters can be divided into two primary groups both bloodstream infections that can be traced back to catheters and those that can be traced back to central lines. There are clear differences between the two, despite the fact that they are interchangeable. Infections that cannot be traced to an infection unrelated to a catheter but still arise when a central venous catheter is present or within 48 h after the catheter has been withdrawn are referred to as having a “central line-associated bloodstream infection” (CLABSI). A “bundle” of catheter care refers to the provision of care utilizing a consistent combination of actions to reduce the risk of bloodstream infections associated with central lines CLABSIs. Hand hygiene, the use of maximum sterile barriers during line insertion, the washing of the insertion site with chlorhexidine, avoiding the use of the femoral and jugular sites for line insertion, and the timely removal of superfluous catheters are all components of this combination. The implementation of an evidence-based CLABSI prevention bundle and process monitoring by direct observation led to a considerable improvement in reducing the CLABSI rate in adult intensive care unit patients, which was then maintained over time.