Background During pandemic only a few sick patients were admitted to the hospital. Hence, for most of the clinical teaching of student nurses, nursing faculty has to be dependent on teaching in the laboratory. The teaching was done either on simulators or by video-assisted teaching instead of the traditional demonstration method. It is imperative to assess the impact of these methods of teaching on the skill of nursing students. Aim To assess the effectiveness of structured video-assisted learning (VAL) vs demonstration of closed tracheal suction (CTS) in developing skill of undergraduate student nurses. Methodology A quasi-experimental, posttest control group design was adopted. A total of 60 undergraduate B.Sc. second-year student nurses (30 in the demonstration and 30 in the VAL group) were enrolled in this study. The tools used were knowledge assessment tool (KAT) on CTS, practice assessment tool (PAT) to assess the knowledge and skill of CTS simultaneously. Google forms with a five-point Likert scale were developed to assess the perception of Students and Faculty regarding VAL on CTS. Results The mean scores of CTS were significantly higher in the demonstration group when compared with the VAL group at P < 0.05. Conclusion Students liked the video, but the demonstration was proved to be a better method to develop the skill in CTS.