Impact of temperature on the toxicity of Kraft 36 EC® (a.s. abamectin) and Score 250 EC® (a.s. difenoconazole) to soil organisms under realistic environmental exposure scenarios

Figueirêdo, Lívia Pitombeira de; Athayde, Danillo B.; Daam, Michiel A.; Gestel, Cornelis A.M. van; Guerra, Glauce da Silva; Duarte‐Neto, Paulo José; Espíndola, Evaldo Luiz Gaeta

doi:10.1016/j.ecoenv.2020.110446

Cited by 20 publications

(4 citation statements)

References 49 publications

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“…In addition, there were no significant differences compared with the CK and SK. Previous studies found that AVM could affect the growth of plants, and it demonstrated that there was the encapsulation effect of γ-CD–MOFs on AVM TC. For the treatment of steam, on the 7th and 14th days, except for M-B, all other treatments had inhibitory effects.…”

Section: Results and Discussionmentioning

confidence: 95%

Multifunctional γ-Cyclodextrin-Based Metal–Organic Frameworks as Avermectins Carriers for Controlled Release and Enhanced Acaricidal Activity

Chen

Shan

et al. 2023

ACS Agric. Sci. Technol.

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A controlled pesticide delivery system has attracted considerable attention in recent years. Metal–organic frameworks (MOFs), which are one of the most rapidly developing porous materials, have been used as pesticide carriers. However, the inherent toxicity of reported metal nodes or the expensiveness of organic ligands is not desirable, which limits the practical application of such pesticide-loaded MOF delivery systems. γ-Cyclodextrin-based MOFs (γ-CD–MOFs) are considered as a green renewable framework material; however, it has been less exploited as a multifunctional pesticide carrier in agricultural applications. In this study, avermectins (AVM) were loaded into γ-CD–MOFs (AVM−γ-CD–MOFs) with a loading content of 20.41% by physical absorption. AVM−γ-CD–MOFs exhibited pH-responsive release profiles and had better stability under photoirradiation. Moreover, it could promote the growth of cotton roots and stems, improve the chlorophyll content, and decrease malondialdehyde content to a certain extent by facilitating the activities of peroxidase. Compared with AVM technical concentrate wettable powder, the AVM−γ-CD–MOF wettable powder exhibited a better acaricidal activity against Panonychus citri (McGregor). In short, this research explores the feasibility of γ-CD–MOFs as a platform for potential application in sustainable plant protection.

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Section: Results and Discussionmentioning

confidence: 95%

Multifunctional γ-Cyclodextrin-Based Metal–Organic Frameworks as Avermectins Carriers for Controlled Release and Enhanced Acaricidal Activity

Chen

Shan

et al. 2023

ACS Agric. Sci. Technol.

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“…They aim to eliminate or control pests that harms plants, nematodes, microorganisms, and insects that compete with human food and are responsible for transmitting disease and destroying crops (Brasil, 2002; Instituto Nacional de Câncer José Alencar Gomes da Silva, 2021; Kumar et al, 2021). Brazil is one of the largest agricultural producers, resulting in a high pesticide consumption (i.e., about 20% of global use) (Figueirêdo et al, 2020; Lopes‐Ferreira et al, 2022; Rigotto et al, 2014). However, this intensive use may cause several adverse effects (Moraes, 2019).…”

Section: Introductionmentioning

confidence: 99%

Effects of the pyriproxyfen and fenthion on the gonadal morphology of Nile tilapia (Oreochromis niloticus: Perciformes, Cichlidae)

Moises Marques e Silva,

Lins Oliveira,

B. Silva Farias

et al. 2024

Journal of Fish Biology

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Commercially available insecticides present acute toxicity to the health of fish and other aquatic organisms, which may impair the local aquaculture. This study evaluated the gonadal morphology of freshwater fish exposed to pyriproxyfen and fenthion. Forty‐five juvenile male Nile tilapias (Oreochromis niloticus) were divided into control, pyriproxyfen‐exposed (0.01 g/L), and fenthion‐exposed (0.001 g/L) groups. They were evaluated in three moments (30, 60, and 90 days). The variables analyzed were the gonadosomatic index (GSI), weight to length ratio, seminiferous tubules morphometry (diameter and height), tissue damage, and immunohistochemical analysis for caspase‐3, tumor necrosis factor alpha (TNF‐α), and vascular endothelial growth factor (VEGF). Pyriproxyfen and fenthion injured the seminiferous tubule tissue, and the damage progressed according to the exposure time. In addition, the GSI gradually reduced over time in all groups compared with the first moment (30 days), while caspase‐3, TNF‐α, and VEGF values increased only in the fenthion‐exposed group. Therefore, pyriproxyfen and fenthion changed the gonadal morphology of male Oreochromis niloticus, which may affect their reproduction in the wild or captivity.

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“…Due to the wide application and high persistence of DFZ, it can be detected in soil [5], water [6], air [7], and agricultural crops [8]. It was reported that over 1% of soil samples from northern China had DFZ concentrations higher than 0.1 mg/kg [9], the concentration of DFZ in agricultural water in Thailand (Salakru, Nong Sua) was estimated to be 0.028 mg/L, and the concentration of DFZ in air samples from Tanjung Karang was 86.49 ng/m −3 [10].…”

Section: Introductionmentioning

confidence: 99%

Difenoconazole Exposure Induces Retinoic Acid Signaling Dysregulation and Testicular Injury in Mice Testes

Zheng¹,

Ya²,

Chen³

et al. 2023

Toxics

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Difenoconazole (DFZ) is a broad-spectrum triazole fungicide that is widely utilized in agriculture. Although DFZ has been demonstrated to induce reproductive toxicity in aquatic species, its toxic effects on the mammalian reproductive system have yet to be fully elucidated. In vivo, male mice were administered 0, 20 or 40 mg/kg/d of DFZ via oral gavage for 35 days. Consequently, DFZ significantly decreased testicular organ coefficient, sperm count and testosterone levels, augmented sperm malformation rates, and elicited histopathological alterations in testes. TUNEL assay showed increased apoptosis in testis. Western blotting results suggested abnormally high expression of the sperm meiosis-associated proteins STRA8 and SCP3. The concentrations of retinoic acid (RA), retinaldehyde (RE), and retinol (ROL) were increased in the testicular tissues of DFZ-treated groups. The mRNA expression level of genes implicated in RA synthesis significantly increased while genes involved in RA catabolism significantly decreased. In vitro, DFZ reduced cell viability and increased RA, RE, and ROL levels in GC-2 cells. Transcriptome analysis revealed a significant enrichment of numerous terms associated with the RA pathway and apoptosis. The qPCR experiment verified the transcriptome results. In conclusion, our results indicate that DFZ exposure can disrupt RA signaling pathway, homeostasis, and induce testicular injury in mice testes.

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Impact of temperature on the toxicity of Kraft 36 EC® (a.s. abamectin) and Score 250 EC® (a.s. difenoconazole) to soil organisms under realistic environmental exposure scenarios

Abstract: Impact of temperature on the toxicity of Kraft 36 EC® (a.s. abamectin) and Score 250 EC® (a.s. difenoconazole) to soil organisms under realistic environmental exposure scenarios

Cited by 20 publications

References 49 publications

Multifunctional γ-Cyclodextrin-Based Metal–Organic Frameworks as Avermectins Carriers for Controlled Release and Enhanced Acaricidal Activity

Multifunctional γ-Cyclodextrin-Based Metal–Organic Frameworks as Avermectins Carriers for Controlled Release and Enhanced Acaricidal Activity

Effects of the pyriproxyfen and fenthion on the gonadal morphology of Nile tilapia (Oreochromis niloticus: Perciformes, Cichlidae)

Difenoconazole Exposure Induces Retinoic Acid Signaling Dysregulation and Testicular Injury in Mice Testes

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