Impact of the 1998 World Health Organization/International Society of Urological Pathology Classification System for Urothelial Neoplasms of the Kidney

Genega, Elizabeth M.; Kapali, Malathy; Torres-Quinones, Marta; Huang, Wei; Knauss, Jill; Wang, L.-P.; Raghunath, Puthiyaveettil N.; Kozlowski, Christopher; Malkowicz, S. Bruce; Tomaszewski, John E.

doi:10.1016/s0022-5347(05)00433-7

Cited by 6 publications

(8 citation statements)

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“…In contrast, aberrant squamous and/or glandular differentiation in otherwise typical urothelial cancers is by far more common, occurring in 7-60% of bladder [1,9,22,26,29,30,42,45] and 10-15% of upper urinary tract UCs [7,11]. In our series, squamous or glandular differentiation occurred in 74/268 (28%) upper urinary tract tumors, its presence being significantly correlated with high tumor stage and grade.…”

Section: Discussioncontrasting

confidence: 51%

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Patterns of invasion and histological growth as prognostic indicators in urothelial carcinoma of the upper urinary tract

et al. 2006

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The biological significance of squamous and glandular differentiation and different patterns of invasion in upper urinary tract urothelial carcinoma is unclear. We reviewed 268 cases of consecutive upper urinary tract carcinomas with respect to the presence of squamous and/or glandular differentiation and different patterns of invasion (nodular, trabecular, and infiltrative) and correlated data with patient outcome. Squamous or glandular differentiation occurred in 47/268 (18%) tumors and its presence correlated with high tumor stage (P<0.001) and grade (P<0.001). Invasive patterns were nodular in 49/227 (22%), trabecular in 95/227 (42%), and infiltrative in 83/227 (37%) tumors. The nodular pattern prevailed in low stage (P<0.001) and low-grade (P<0.001) tumors, whereas the infiltrative pattern prevailed in high stage (P<0.001) and high-grade (P<0.001) tumors. Multivariate analysis proved that tumor stage (P<0.001) and the infiltrative pattern (P<0.001) are independent predictors of metastasis-free survival, whereas tumor grade and squamous and glandular differentiation lacked independent influence on patient outcome. In conclusion, the infiltrative pattern of invasion significantly correlated with advanced disease and poor patient outcome. In contrast, the presence of squamous and/or glandular invasion did not prove independent influence on patient outcome. The pattern of invasion should be commented upon separately in the pathology report.

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Section: Discussioncontrasting

confidence: 51%

“…These areas are most frequently squamous or glandular in nature and their frequency was shown to increase with tumor grade and stage [1,11,42,43,45]. Thus, most urological oncologists share the view that mixed histology implies more aggressive disease, which may be less susceptible to radio-or chemotherapy [16,25,29].…”

Section: Introductionmentioning

confidence: 99%

Patterns of invasion and histological growth as prognostic indicators in urothelial carcinoma of the upper urinary tract

et al. 2006

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“…In the 2004 WHO/ISUP system, however, these grade 2 tumors can be segregated approximately equally into lowand high-grade carcinomas with correspondingly low and high risks of progression. [9][10][11] Several studies have compared the 1973 WHO and newer WHO/ISUP systems. Most have demonstrated a superiority of the WHO/ISUP system in predicting recurrence and progression as well as inter-observer reproducibility, 9,[12][13][14] whereas several others have reported no difference in interobserver reproducibility between two grading systems.…”

Section: Relationship Of 1973 Who To 2004 Who/isup Systemsmentioning

confidence: 99%

Non‐invasive papillary urothelial neoplasms: The 2004 WHO/ISUP classification system

Miyamoto

Miller²,

Fajardo³

et al. 2009

Pathology International

140

117

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The classification and grading of papillary urothelial neoplasms has been a long-standing subject of controversy. Previously, numerous diverse grading schemes for bladder tumor, including the 1973 World Health Organization (WHO) classification, existed whereby one of the major limitations was poor inter-observer reproducibility among pathologists. The WHO/International Society of Urological Pathology (ISUP) consensus classification system of urothelial neoplasms of the urinary bladder was developed in 1998 and was revised most recently in 2003 (published in 2004). Importantly, the current classification system provides detailed histological criteria for papillary urothelial lesions and allows for designation of a lesion (papillary urothelial neoplasm of low malignant potential) with a negligible risk of progression. Thus, the latest system is designed to be a universally acceptable one for bladder tumors that not only could be effectively used by pathologists, urologists, and oncologists, but also stratifies the tumors into prognostically significant categories. This article outlines the 2004 WHO/ISUP classification system regarding the specific histological criteria for non-invasive papillary urothelial neoplasms and the clinical significance of each category.

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“…H&E-stained slides were used to assess histological grade (low and high grade) 21 , pathologic stage (pT) 22 , growth of tumor (papillary/solid), multifocality, and lymphovascular invasion (LVI). Authors compared low stage non-muscle invasive tumor (pTapT1) and high stage muscle invasive (pT2-pT4) tumor 23 .…”

Section: Methodsmentioning

confidence: 99%

Expression of regulatory proteins and proliferative activity in relation to phenotypic characteristics of upper urothelial carcinoma

Dolićanin

Veličković

Djordjević

et al. 2011

VSP

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Impact of the 1998 World Health Organization/International Society of Urological Pathology Classification System for Urothelial Neoplasms of the Kidney

Cited by 6 publications

References 0 publications

Patterns of invasion and histological growth as prognostic indicators in urothelial carcinoma of the upper urinary tract

Patterns of invasion and histological growth as prognostic indicators in urothelial carcinoma of the upper urinary tract

Non‐invasive papillary urothelial neoplasms: The 2004 WHO/ISUP classification system

Expression of regulatory proteins and proliferative activity in relation to phenotypic characteristics of upper urothelial carcinoma

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