Impact of the Addition of Digital Breast Tomosynthesis (DBT) to Standard 2D Digital Screening Mammography on the Rates of Patient Recall, Cancer Detection, and Recommendations for Short-term Follow-up

Powell, Jaclynn L.; Hawley, Jeffrey R.; Lipari, Adele M.; Yıldız, Vedat; Erdal, Barbaros S.; Çarkaci, Selin

doi:10.1016/j.acra.2016.10.001

Cited by 27 publications

(12 citation statements)

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“…After completely reading these references, 18 studies (comprising 26 articles, since some had more than one published article) met our eligibility criteria and therefore were included in this review [4][5][6][7][8][24][25][26][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] .…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen studies evaluated DBT in combination with digital mammography versus digital mammography alone. These studies included: one RCT 24 , five accuracy studies 7,34,35,40,44 , and eight retrospective cohort studies [4][5][6]8,[36][37][38]46 . Six studies, three accuracy studies 35,43,48 , one prospective cohort study 47 , one RCT 25 and one quasi-RCT 26 evaluated the effectiveness of DBT with synthetic mammography versus digital mammography alone.…”

Section: Resultsmentioning

confidence: 99%

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Accuracy and Effectiveness of Mammography versus Mammography and Tomosynthesis for Population-Based Breast Cancer Screening: A Systematic Review and Meta-Analysis

Giampietro

Cabral

Lima

et al. 2020

Sci Rep

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We proposed to compare the accuracy and effectiveness of digital breast tomosynthesis (DBT), plus digital or synthetic mammography, with digital mammography alone in women attending populationbased breast cancer screenings. We performed a systematic review and included controlled studies comparing DBT with digital mammography for breast cancer screening. Search strategies were applied to the MEDLINE, Embase, LILACS, and CENTRAL databases. With moderate quality of evidence, in 1,000 screens, DBT plus digital mammography increased the overall and invasive breast cancer rates by 3 and 2 (RR 1.36, 95% CI 1.18 to 1.58 and RR 1.51, 95% CI 1.27 to 1.79, respectively). DBT plus synthetic mammography increased both overall and invasive breast cancer rates by 2 (RR 1.38, 95% CI 1.24 to 1.54 and RR 1.37, 95% CI 1.22 to 1.55, respectively). DBT did not improve recall, false positive and false negative rates. However due to heterogeneity the quality of evidence was low. For women attending population-based breast cancer screenings, DBT increases rates of overall and invasive breast cancer. There is no evidence with high or moderate quality showing that DBT compared with digital mammography decreases recall rates, as well as false positive and false negative rates.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Accuracy and Effectiveness of Mammography versus Mammography and Tomosynthesis for Population-Based Breast Cancer Screening: A Systematic Review and Meta-Analysis

Giampietro

Cabral

Lima

et al. 2020

Sci Rep

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“…However, study results for calcifications vary from equal, greater, or lower clarity between both systems (19)(20)(21). Only a few data on the influence of DBT on BI-RADS 3 lesions within the same group of patients have been published (22,23).…”

Section: Introductionmentioning

confidence: 99%

Breast tomosynthesis for the clarification of mammographic BI-RADS 3 lesions can decrease follow-up examinations and enables immediate cancer diagnosis

Bahrs¹,

Otto²,

Hattermann³

et al. 2018

Acta Radiol

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Background The limited sensitivity of mammography in case of a high breast density often produces unclear or false-positive findings, so-called BI-RADS 3 lesions, which have to be followed up to prove benignity. Digital breast tomosynthesis (DBT) was developed to reduce such summation effects. Purpose To evaluate the influence of an additional DBT on the management of mammographic BI-RADS 3 findings and whether DBT can decrease the time to definitive diagnosis or not. Material and Methods We analyzed 87 patients with a mammographic non-calcified BI-RADS 3 lesion who underwent an additional DBT of the affected breast. A follow-up two-dimensional (2D) examination or a histological result of the lesion had to be available. The images were analyzed especially for the BI-RADS category and incremental diagnostic accuracy. Moreover, the inter-reader reliability and the radiation dose were evaluated. Results The BI-RADS category has been changed by the addition of DBT: 57.1% were assessed as BI-RADS 1 or 2, 4.6% as BI-RADS 4, and only 38.3% remained as BI-RADS 3. The intraclass correlation coefficient for the three readers showed a good agreement for inter-reader reliability. No false-negative examination was found in the follow-ups. Nine lesions were biopsied (seven benign, two malignant). Both malignant lesions were suspicious in the DBT (BI-RADS 4). A significant higher glandular dose was necessary for the DBT. Conclusion DBT has the potential to reduce the recall-rate of BI-RADS 3 lesions and to find and diagnose malignant lesions earlier than 2D mammography alone.

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“…A number of studies in which Hologic systems are used to detect cancer agree that there is an increase in detection rate with the addition of DBT to DM; however, there is a conflict on whether this increase is significant 37,38,42,43,47,48,57–61,63–68,70,71,75–77,80. Specifically, for ductal carcinoma in situ (an entity often presenting as microcalcifications), a significant difference was found in favor of DM&DBT versus DM alone 65…”

Section: Results: Studies On the Optimal Use Of Digital Breast Tomosymentioning

confidence: 99%

<p>The role of digital breast tomosynthesis in breast cancer screening: a manufacturer- and metrics-specific analysis</p>

Hadjipanteli

Kontos

Constantinidou

2019

CMAR

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Aim: Digital Breast Tomosynthesis (DBT), with or without Digital Mammography (DM) or Synthetic Mammography (SM), has been introduced or is under consideration for its introduction in breast cancer screening in several countries, as it has been shown that it has advantages over DM. Despite this there is no agreement on how to implement DBT in screening, and in many cases there is a lack of official guidance on the optimum usage of each commercially available system. The aim of this review is to carry out a manufacturerspecific summary of studies on the implementation of DBT in breast cancer screening. Methods: An exhaustive literature review was undertaken to identify clinical observer studies that evaluated at least one of five common metrics: sensitivity, specificity, area under the curve (AUC) of the receiver-operating characteristics (ROC) analysis, recall rate and cancer detection rate. Four common DBT implementation methods were discussed in this review: (1) DBT, (2) DM with DBT, (3) 1-view DBT with or without 1-view DM or 2-view DM and (4) DBT with SM. Results: A summary of 89 studies, selected from a database of 677 studies, on the assessment of the implementation of DBT in breast cancer screening is presented in tables and discussed in a manufacturer-and metric-specific approach. Much more studies were carried out using some DBT systems than others. For one implementation method of DBT by one manufacturer there is a shortage of studies, for another implementation there are conflicting results. In some cases, there is a strong agreement between studies, making the advantages and disadvantages of each system clear. Conclusion: The optimum implementation method of DBT in breast screening, in terms of diagnostic benefit and patient radiation dose, for one manufacturer does not necessarily apply to other manufacturers.

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Impact of the Addition of Digital Breast Tomosynthesis (DBT) to Standard 2D Digital Screening Mammography on the Rates of Patient Recall, Cancer Detection, and Recommendations for Short-term Follow-up

Cited by 27 publications

References 50 publications

Accuracy and Effectiveness of Mammography versus Mammography and Tomosynthesis for Population-Based Breast Cancer Screening: A Systematic Review and Meta-Analysis

Accuracy and Effectiveness of Mammography versus Mammography and Tomosynthesis for Population-Based Breast Cancer Screening: A Systematic Review and Meta-Analysis

Breast tomosynthesis for the clarification of mammographic BI-RADS 3 lesions can decrease follow-up examinations and enables immediate cancer diagnosis

<p>The role of digital breast tomosynthesis in breast cancer screening: a manufacturer- and metrics-specific analysis</p>

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