Impact of the canine double-deletion β1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a β1-selective β-blocker

Abstract

ADRB1 deletions appear to have structural and functional consequences. Individual genome-based treatment recommendations could impact the management of dogs with heart disease.

Acute echocardiographic effects of sotalol on ventricular systolic function in dogs with ventricular arrhythmias

“…In addition, we did not determine if the dogs in our study were affected by a β–adrenergic receptor polymorphism . These polymorphisms have been shown to impact heart rate response to atenolol in healthy dogs, and, as such, their possible role in our patient population is unknown . These limitations are certainly potential explanations for the variability of an individual dog's response to sotalol depicted for each of the echocardiographic indices in Figure .…”

“…30 These polymorphisms have been shown to impact heart rate response to atenolol in healthy dogs, and, as such, their possible role in our patient population is unknown. 31 These limitations are certainly potential explanations for the variability of an individual dog's response to sotalol depicted for each of the echocardiographic indices in Figure 1. We were unable to identify common characteristics such as breed or type or severity of structural cardiac disease in the minority of dogs that did not show a mild decrease in systolic function post-sotalol (ie, the 5 dogs in which LV EF increased post-sotalol).…”

Effect of preoperative administration of atenolol to dogs with pulmonic stenosis undergoing interventional procedures

“…receptor have been identified in dogs, and these could also affect individual response to a given drug dose. 27 We did not attempt to account for this genetic variability in our study, so it could represent a confounding factor.…”

Effects of 0.5% Timolol Maleate Ophthalmic Solution on Heart Rate and Selected Echocardiographic Indices in Apparently Healthy Cats

“…In humans, genetic polymorphisms that result in variable response to beta‐blocker treatment could alter therapeutic choices . This pharmacogenetic effect on medication administration also has been demonstrated in dogs . Although the functional effects of feline beta receptor polymorphism are not well documented, this remains an area of interest for future investigation.…”

“…34 This pharmacogenetic effect on medication administration also has been demonstrated in dogs. 35 Although the functional effects of feline beta receptor polymorphism are not well documented, this remains an area of interest for future investigation. In our study, an influence of the documented P277Q ADRB1 polymorphism was not responsible for the variable response to timolol.…”