Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK

Campbell, Cori; Wang, Tingyan; Smith, David A.; Freeman, Oliver; Noble, Theresa; Várnai, Kinga A; Harris, Steve; Salih, Hizni; Roadknight, Gail; Little, Stephanie; Glampson, Ben; Mercuri, Luca; Papadimitriou, Dimitri; Jones, Christopher R.; Taylor, Vince; Chaudhry, Afzal; Phan, Hang; Borca, Florina; Olza, Josune; Warricker, Frazer; Romão, Luis; Ramlakhan, David; English, Louise; Klenerman, Paul; Andersson, Monique; Collier, Jane; Nastouli, Eleni; Khakoo, Salim I.; Gelson, William; Cooke, Graham; Woods, Kerrie; Davies, Jim; Barnes, Eleanor; Matthews, Philippa C.

doi:10.1101/2021.11.10.21265651

Cited by 3 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, treatment data are most comprehensively captured in secondary/tertiary care records where HBV prescribing is based (60). In the NIHR Health Informatics Collaborative (HIC) secondary care EHR database, 16% of CHB patients were receiving antiviral treatment (61). Clinical guidelines recommend criteria for treatment, but it is not possible for us to determine the extent to which the 88% of patients with no treatment recorded are treatment ineligible, or are receiving treatment in a secondary/tertiary care setting that is not captured in QResearch data.…”

Section: Caveats Of Primary Care Ehr Analysis -Missing Datamentioning

confidence: 99%

Analysis of electronic health record data of hepatitis B virus (HBV) patients in primary care: hepatocellular carcinoma (HCC) risk associated with socioeconomic deprivation and reduced by statins

Campbell

Wang

Gillespie

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Chronic hepatitis B infection (CHB) is the leading global cause of hepatocellular carcinoma (HCC), however the CHB population in the UK is not well characterised, and few investigations of risk factors for progression to HCC in multiethnic populations have been undertaken. Methods: We identified CHB individuals from the English primary care database QResearch, containing >35 million patient records. Individuals ≥18 years with a record of CHB between 1999-2019 were included. Risk factors for HCC were investigated using Cox proportional hazards modelling. Results: We identified 8039 individuals with CHB in whom median follow-up was 3.87 years (interquartile range (IQR) 6.30 years). Most individuals (60.4%) were males of non-White ethnicities (>70%), and 44% were in the fifth (most deprived) Townsend deprivation quintile. In multivariable Cox proportional hazards models (undertaken in a subset of 7029 individuals with longitudinal data), 161 HCC cases occurred. Increased hazards of HCC associated with male sex (adjusted hazards ratio (aHR) 3.44, 95% Confidence Interval (95CI) 2.07-5.73), older age (for age groups 56-55 and ≥66 years of age, compared to 26-35 years, aHRs 7.52 (95CI 4.14-13.67) and 11.89 (95CI 6.26-22.60) respectively), socioeconomic deprivation (aHR for fifth Townsend deprivation quintile 1.69, 95CI 1.01-2.84, compared to third), Caribbean ethnicity (aHR 3.32, 95CI 1.43-7.71, compared to White ethnicity), ascites (aHR 1.85, 95CI 1.02-3.36), cirrhosis (aHR 6.52, 95CI 4.54-9.37) and peptic ulcer disease (aHR 2.20, 95CI 1.39-3.49). Reduced HCC hazards associated with statin use (aHR 0.47, 95CI 0.22-0.99). Conclusions: We identified novel risk factors for HCC in an ethnically diverse and socioeconomically deprived population of adults living with CHB.

show abstract

Section: Caveats Of Primary Care Ehr Analysis -Missing Datamentioning

confidence: 99%

Analysis of electronic health record data of hepatitis B virus (HBV) patients in primary care: hepatocellular carcinoma (HCC) risk associated with socioeconomic deprivation and reduced by statins

Campbell

Wang

Gillespie

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset

Wang

Smith

Campbell

et al. 2022

International Journal of Epidemiology

Self Cite

View full text Add to dashboard Cite

From Paper to Digital: Performance and Challenges of the Electronic Hepatitis B Surveillance System in Ninh Binh, Northern Vietnam (2017–2022)

Nguyen,

Pham,

Hoang

et al. 2024

TropicalMed

View full text Add to dashboard Cite

Hepatitis B remains a major public health issue in Vietnam. Mandatory reporting to the national electronic communicable disease surveillance system (eCDS) has been required since July 2016. We conducted an evaluation of the hepatitis B surveillance system in Ninh Binh, the province with the highest reported burden of hepatitis B in Northern Vietnam, between 2017 and 2022. Using the CDC’s guidelines for evaluating public health surveillance systems, we assessed four key attributes: simplicity, timeliness, data quality, and acceptability. This retrospective evaluation included document reviews, analysis of hepatitis B data, and in-depth interviews with provincial-level healthcare staff involved in the reporting of hepatitis B cases. The results showed that the eCDS improved reporting frequency, provided more detailed case information, and enhanced data accessibility compared to the previous paper-based system. However, the system faced several challenges, including unclear objectives, difficulties in distinguishing acute from chronic cases, insufficient training for staff, lack of supervision for data quality, and technical software issues. Despite these challenges, stakeholders found the system acceptable but emphasized the need for improvements, including revising the system’s objectives, automating case classification, enhancing training, securing funding for maintenance, and implementing regular data review processes.

show abstract

Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK

Cited by 3 publications

References 7 publications

Analysis of electronic health record data of hepatitis B virus (HBV) patients in primary care: hepatocellular carcinoma (HCC) risk associated with socioeconomic deprivation and reduced by statins

Analysis of electronic health record data of hepatitis B virus (HBV) patients in primary care: hepatocellular carcinoma (HCC) risk associated with socioeconomic deprivation and reduced by statins

Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset

From Paper to Digital: Performance and Challenges of the Electronic Hepatitis B Surveillance System in Ninh Binh, Northern Vietnam (2017–2022)

Contact Info

Product

Resources

About