Impact of the COVID-19 pandemic on new starts to oral oncology medications in the US

Neilson, Lynn M.; Kohli, Monal; Munshi, Kiraat D.; Peasah, Samuel K.; Henderson, Rochelle; Passero, Vida; Good, Chester B.

doi:10.1177/10781552211073778

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…The curtailment of normal clinical activities in Pakistani hospitals to limit the spread of COVID-19 had led to disruptions in the care of cancer patients [ 8 ]. Although the long-term implications of delays and disruptions in health care services for cancer patients are yet to be seen, there is concern that patient outcomes may be negatively impacted [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Experiences of Newly Diagnosed Oral Cancer Patients during the First Wave of the COVID-19 Pandemic: A Qualitative Study from Pakistan

Khattak

Khan

et al. 2022

IJERPH

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The COVID-19 pandemic has resulted in the scaling back or postponement of non-emergency hospital services, including care of cancer patients. The present qualitative study explored the experiences of newly diagnosed oral cancer patients during the first wave of the COVID-19 pandemic in Pakistan. Patients who attended the Department of Maxillofacial Surgery, Khyber College of Dentistry in July 2020 were selected using a maximum variation purposive sampling method. Seventeen semi-structured interviews were conducted in Pashto, the local language of Khyber Pakhtunkhwa. All interviews were audiotaped, transcribed verbatim, and translated into English. Thematic content analysis yielded eight major themes: pain and generalised physical weakness, shock at diagnosis, psychological distress of the COVID-19 pandemic, faith and religion, double hit loss of employment, social isolation, social support from caregivers, and lack of support from health care professionals. In conclusion, the COVID-19 pandemic has a clear impact on the life experiences of newly diagnosed oral cancer patients. Distress due to delay in accessing health care and lack of support from health care providers are a matter of great concern. Appropriate interventions should be introduced to ensure psychological and social support strategies are in place for patients during interruptions of health care services.

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Section: Introductionmentioning

confidence: 99%

Experiences of Newly Diagnosed Oral Cancer Patients during the First Wave of the COVID-19 Pandemic: A Qualitative Study from Pakistan

Khattak

Khan

et al. 2022

IJERPH

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AutoML-Driven Insights into Patient Outcomes and Emergency Care During Romania’s First Wave of COVID-19

Simon,

Bibi,

Schaffert

et al. 2024

Bioengineering

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Background: The COVID-19 pandemic severely impacted healthcare systems, affecting patient outcomes and resource allocation. This study applied automated machine learning (AutoML) to analyze key health outputs, such as discharge conditions, mortality, and COVID-19 cases, with the goal of improving responses to future crises. Methods: AutoML was used to train and validate models on an ICD-10 dataset covering the first wave of COVID-19 in Romania (January–September 2020). Results: For discharge outcomes, Light Gradient Boosted models achieved an F1 score of 0.9644, while for mortality 0.7545 was reached. A Generalized Linear Model blender achieved an F1 score of 0.9884 for “acute or emergency” cases, and an average blender reached 0.923 for COVID-19 cases. Older age, specific hospitals, and oncology wards were less associated with improved recovery rates, while mortality was linked to abnormal lab results and cardiovascular/respiratory diseases. Patients admitted without referral, or patients in hospitals in the central region and the capital region of Romania were more likely to be acute cases. Finally, counties such as Argeş (South-Muntenia) and Brașov (Center) showed higher COVID-19 infection rates regardless of age. Conclusions: AutoML provided valuable insights into patient outcomes, highlighting variations in care and the need for targeted health strategies for both COVID-19 and other health challenges.

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Impact of COVID-19 Pandemic on Non-Small Cell Lung Cancer Care

Zhai¹,

Chopra²,

Kang³

et al. 2023

Current Oncology

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We assessed the impact of COVID-19 on healthcare visits, timing of stage IV NSCLC diagnosis and immunotherapy initiation, and rates of switching to extended dosing schedules of immunotherapies among patients with stage IV NSCLC. This retrospective study examined electronic health record data of adult patients receiving treatment for stage IV NSCLC within The US Oncology Network and Onmark. Endpoints were compared for February–July 2019 (before COVID) vs. February–July 2020 (during COVID). The study found rapid decreases in numbers of patients with clinic/vital visits, immunotherapy initiations, and new diagnoses of stage IV NSCLC during April–May 2020 vs. April–May 2019. The rate of delays of immunotherapy administrations and proportions of patients with such delays increased from February to March of 2020. These patterns may have resulted from the increase in COVID-19 cases during this period and the corresponding quarantine and lockdowns. However, when comparing pre COVID-19 and during COVID-19 for May and after, the differences in delay of immuno-oncology administrations became less marked, likely due to lifting of lockdowns. The rate of switching from shorter to longer dosing schedules increased from May–July 2020. This was mainly attributed to pembrolizumab, likely due to FDA approval of the pembrolizumab 6W dosing schedule in April 2020.

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Impact of the COVID-19 pandemic on new starts to oral oncology medications in the US

Cited by 3 publications

References 17 publications

Experiences of Newly Diagnosed Oral Cancer Patients during the First Wave of the COVID-19 Pandemic: A Qualitative Study from Pakistan

Experiences of Newly Diagnosed Oral Cancer Patients during the First Wave of the COVID-19 Pandemic: A Qualitative Study from Pakistan

AutoML-Driven Insights into Patient Outcomes and Emergency Care During Romania’s First Wave of COVID-19

Impact of COVID-19 Pandemic on Non-Small Cell Lung Cancer Care

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