Impact of the COVID-19 Pandemic on Cardiovascular Health in 2020

Roth, Gregory A.; Vaduganathan, Muthiah; Mensah, George A.

doi:10.1016/j.jacc.2022.06.008

“…The impact of COVID-19 on cardiovascular mortality, in particular, appears to have varied widely, with no large increases seen in a number of the most developed countries but marked increases in hypertensive heart disease mortality seen in the United States in 2021. 14 The potential contribution of COVID-19 to these deaths, either directly or indirectly, remains to be determined. The lessons learned from these studies will play an important role as the world continues to navigate waves of the COVID-19 pandemic and plans for future public health crises.…”

Section: Implications For Clinical and Public Health Practice And Res...mentioning

confidence: 99%

Acute Cardiovascular Complications of COVID-19

Mensah

¹

,

Vaduganathan

²

,

Roth

³

2023

Journal of the American College of Cardiology

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“…With regard to cardiovascular medicine, it is desirable to know specific genetic risk factors for the development of myocarditis during COVID-19 or upon vaccination [112,[165][166][167][168][169][170][226][227][228][229][230][231][232], or for development of long COVID syndromes [191,[233][234][235][236][237][238][239]. Fortunately, SARS-CoV-2 is rather rarely causing severe myocarditis or cardiomyopathies [165][166][167][168][169][170].…”

Section: Cardiovascular Immunobiology Of Covid-19 and Long Covid Synd...mentioning

confidence: 99%

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Poller¹,

Heidecker²,

Ammirati³

et al. 2022

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During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

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“…With regard to cardiovascular medicine, it is desirable to know specific genetic risk factors for the development of myocarditis during COVID-19 or upon vaccination [112,[164][165][166][167][168][169][204][205][206][207][208][209], or for development of long COVID syndromes [190,[210][211][212][213].…”

Section: Cardiovascular Immunobiology Of Covid-19 and Long Covid Synd...mentioning

confidence: 99%

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Poller¹,

Heidecker²,

Ammirati³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

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Impact of the COVID-19 Pandemic on Cardiovascular Health in 2020

Cited by 63 publications

References 50 publications

Acute Cardiovascular Complications of COVID-19

Acute Cardiovascular Complications of COVID-19

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

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