Impact of the COVID-19 pandemic on severe non-SARS-CoV-2 community-acquired pneumonia in Reunion Island: a multicenter retrospective observational study, 2016–2021

Combe, Agathe; Kovacs, David; de Mangou, Axel; Miltgen, Guillaume; Traversier, Nicolas; Belmonte, Olivier; Simon, Olivier; Vidal, Charles; Coolen-Allou, Nathalie; Allyn, Jérôme; Allou, Nicolas

doi:10.1038/s41598-023-40791-5

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…A study conducted in Mexico found that the average number of seasonal in uenza cases during the COVID-19 pandemic decreased by 64% compared to the number in the pre-pandemic years, which was likely attributable to the containment measures implemented to control SARS-CoV-2 infection [11]. This phenomenon was also observed in other cities worldwide [30][31][32][33]. It has long been recognized that Flu, RSV, and CoV outbreaks occur in temperate climates during winter, whereas low activity is detected during summer [34].…”

Section: Discussionmentioning

confidence: 85%

Frequency of Respiratory Virus-Associated infection among Children and Adolescents from a Tertiary-Care Hospital in Mexico City

Nieto-Rivera,

Saldaña-Ahuactzi,

Parra-Ortega

et al. 2023

Preprint

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Acute respiratory infections (ARIs) are a major cause of morbidity and mortality among children. The causative pathogens show geographic and seasonal variations. We retrospectively evaluated the frequency and seasonality of respiratory pathogens in children and adolescents (age: 0–19 years) with ARIs treated between January 1, 2021, and March 31, 2022, at a single center in Mexico. Out of 2,400 patients, 1,603 were diagnosed with SARS-CoV-2 infection and 797 were diagnosed with other common respiratory pathogens (CRPs). Of the 797, 632 patients were infected with one CRP and 165 with >2 CRPs. Deaths occurred only in SARS-CoV-2-infected patients. Rhinovirus/Enterovirus, respiratory syncytial virus B, and parainfluenza virus 3 were the most prevalent in cases with single and multiple infections. The respiratory pathogens showed a high frequency between autumn and winter of 2021, generating the highest incidence of hospitalization compared to COVID-19. The main comorbidities were immunosuppression, cardiovascular disease (CD), and asthma. The frequency of CRPs showed a downward trend throughout the first half of 2021. CRPs increased in single- and co-infection cases between the fourth and fifth waves of COVID-19, probably due to decreased nonpharmaceutical interventions. Age, cyanosis (symptom), and immunosuppression (comorbidity) were found to differentiate between SARS-CoV-2 infection and CRP infection.

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Section: Discussionmentioning

confidence: 85%

Frequency of Respiratory Virus-Associated infection among Children and Adolescents from a Tertiary-Care Hospital in Mexico City

Nieto-Rivera,

Saldaña-Ahuactzi,

Parra-Ortega

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City

Nieto-Rivera,

Saldaña-Ahuactzi,

Parra-Ortega

et al. 2023

Sci Rep

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Acute respiratory infections (ARIs) are a major cause of morbidity and mortality among children. The causative pathogens show geographic and seasonal variations. We retrospectively evaluated the frequency and seasonality of respiratory pathogens in children and adolescents (age: 0–19 years) with ARIs treated between January 1, 2021, and March 31, 2022, at a single center in Mexico. Out of 2400 patients, 1,603 were diagnosed with SARS-CoV-2 infection and 797 were diagnosed with other common respiratory pathogens (CRPs). Of the 797 patients, 632 were infected with one CRP and 165 with > 2 CRPs. Deaths occurred only in SARS-CoV-2-infected patients. Rhinovirus/Enterovirus, respiratory syncytial virus B, and parainfluenza virus 3 were the most prevalent in cases with single and multiple infections. CRP showed a high frequency between autumn and winter of 2021, with higher incidence of hospitalization compared to COVID-19. The main comorbidities were immunosuppression, cardiovascular disease (CD), and asthma. The frequency of CRPs showed a downward trend throughout the first half of 2021. CRPs increased in single- and co-infection cases between the fourth and fifth waves of COVID-19, probably due to decreased nonpharmaceutical interventions and changes in diagnostic tests. Age, cyanosis (symptom), and immunosuppression (comorbidity) were found to differentiate between SARS-CoV-2 infection and CRP infection.

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Severe community‐acquired pneumonia compared to severe community‐acquired Acinetobacter baumannii pneumonia in Reunion Island: A retrospective study

Rotini,

de Mangou,

Combe

et al. 2024

Tropical Med Int Health

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Acinetobacter baumannii (Ab) has emerged in the last decades as a cause of community‐acquired pneumonia (CAP) in tropical and subtropical regions. We previously conducted the first investigation on this topic in France with a case series of severe CAP‐Ab in Reunion Island over an eight‐year period. In the present work, we aim to highlight the specific aspects of CAP‐Ab by comparing our case series with an historical cohort (PAC_RUN), obtained by retrospective chart review (2016–2021) of severe community‐acquired pneumonia cases on Reunion Island, in which CAP‐Ab was ruled out. During the study period, eight CAP‐Ab cases were identified, giving an incidence of 0.1 cases per 100,000 people/year, and an incidence of 16.5 cases per 100,000 people/year for non‐Ab‐related CAP (n = 761). By comparing with non‐Ab‐related CAP, patients had more excessive alcohol use (75% vs. 25.6%, p = 0.005) and lower body mass index (21 vs. 24 kg/m2, p = 0.004). Six cases (75%) of CAP‐Ab occurred during the rainy season (p = 0.06). Mortality was higher (62.5% vs. 24.3%, p = 0.02) and time to death was shorter (median 2 days vs. 7, p = 0.009) in the CAP‐Ab group. Bacteraemic pneumonia was strongly associated with CAP‐Ab (62.5% vs. 15.7%, p = 0.004). Significant differences were found in the need for renal replacement therapy (75% vs. 17.2%, p < 0.001), catecholamine use (100% vs. 54.5%, p = 0.01) and use of invasive mechanical ventilation (100% vs. 62.7%, p = 0.03). Also, in the proportion of severe acute respiratory distress syndrome (62.5% vs. 23.2%, p = 0.02), septic shock (100% vs. 40.6%, p < 0.001), and cardiogenic shock (87.5% vs. 15.9%, p < 0.001). Compared to severe non‐Ab‐related CAP, severe CAP‐Ab is characterised by higher mortality, associated with a high frequency of multiple organ failure. Excessive alcohol consumption and malnutrition seem to be risk factors. To improve outcomes, broader spectrum antibiotic therapy must be immediately proposed when CAP‐Ab is suspected.

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Impact of the COVID-19 pandemic on severe non-SARS-CoV-2 community-acquired pneumonia in Reunion Island: a multicenter retrospective observational study, 2016–2021

Cited by 3 publications

References 41 publications

Frequency of Respiratory Virus-Associated infection among Children and Adolescents from a Tertiary-Care Hospital in Mexico City

Frequency of Respiratory Virus-Associated infection among Children and Adolescents from a Tertiary-Care Hospital in Mexico City

Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City

Severe community‐acquired pneumonia compared to severe community‐acquired Acinetobacter baumannii pneumonia in Reunion Island: A retrospective study

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