The climatic change has a visible impact in recent abnormal weather events, such as Pakistan’s intensification of the hydrological cycle with changing precipitation pattern, water availability periods, and weather-induced natural disasters. The rainfall flush flood of 2010 alone displaced millionσ of people and damaged properties in just one stroke. The next year, the shocking rainfall flood of 2011 in Sindh, only underscored the enormity of the challenge posed by climate change. The current paper presents the analysis carried out for one-day annual maximum rainfall for Hyderabad and Nawabshah cities, Sindh, Pakistan for the period from 1961 to 2011 using STATISTICA Software for interpolating and forecasting the rainfall time series. The maximum values of observed rainfall were 250.70mm and 256.30mm, while the minimum values were 3.0mm and 0.0mm for Hyderabad and Nawabshah respectively, while the mean of fifty-one (51) years of rainfall data is 51.96mm and 45.3 mm and the computed standard deviations were 42.693mm and 43.896mm respectively. The difference between the mean and standard deviation of one-day maximum rainfall is small, which showed the consistency of the data. The polynomial trend curved lines exhibited fluctuations in the rainfall data, which indicates a continual change in rainfall behavior. Hence, the rainfall data are subjected to a moving mean smoothing with a duration shorter than 3 years. Through these trends, the future one-day annual maximum rainfall can be predicted. The correlation of one-day annual maximum rainfall between Hyderabad and Nawabshah cities had R2 of 0.973. The computed results of return periods of 3, 5, and 10 years for one-day annual maximum rainfall for both cities revealed that the rainfall values for Hyderabad are higher.