Impact of the Granulation Process on Color Texture of Compacts

Abstract

This paper examines the effect of the granulation process on the color texture of compacted powders and granules. The objective is to obtain information to provide for a better comprehension of granulation mechanisms by using a pigment as a texture marker.This requires the establishment of a methodology both to qualify and quantify the spatial variation of color on the compact surface. This is achieved by color image analysis accompanied by both a statistical and a spatial treatment of the color content in the images.

Evaluation of the Granulometry Impact of the Compression Mixture in the Formulation Development of Tablets

“…Thus, the separation of the granules from the mixture, in the compression step, is a result of the vibrations of the compression equipment or the technological type of feeding (for example the feeding by suction force of the compression mixture) [8]. The most problems appear in the compression phase, and their solutions are difficult and require documentation of the impact on the quality of the finished product, as the validated technological processes have a significant impact on the critical process parameters (compression force and compression speed) and are requiring the revalidation of the process as well [4,11,14,15]. Therefore, the diameter of the granules must be carefully selected following technological studies and adequately documented in order to prevent further technological problems, especially in the current production phase with the aim of marketing the product [4,9,11].…”

“…The most problems appear in the compression phase, and their solutions are difficult and require documentation of the impact on the quality of the finished product, as the validated technological processes have a significant impact on the critical process parameters (compression force and compression speed) and are requiring the revalidation of the process as well [4,11,14,15]. Therefore, the diameter of the granules must be carefully selected following technological studies and adequately documented in order to prevent further technological problems, especially in the current production phase with the aim of marketing the product [4,9,11]. The current study aimed to evaluate the impact and the dependence relationship between the size of the granules in the compression mixture and the hardness of the tablet, height, friability, diameter and aspect, respectively the technological variations of the technical parameters, together with dissolution studies [15].…”