Introduction:
Assisted PD is used as an alternative option for the growing group of frail, older ESRD patients unable to perform their own PD. This study was undertaken to investigate the outcomes of assisted PD in older patients by comparing assisted PD patients with self-care PD patients.
Methods
This study included all patients aged 70 or older who started on PD in our hospital from 2009 to 2018. Patients were divided into assisted PD group and self-care PD group according to the independence of bag exchange, and followed up until death, PD cessation or to the end of the study (December 31, 2019). Survival curves were generated using the Kaplan-Meier method and risk factors associated with mortality, peritonitis and technique failure were evaluated using both cause-specific hazards and subdistribution hazards models.
Results
180 patients were enrolled, including 106 (58.9%) males with a median age of 77.5 (77.2–81.2) years. Among the 180 patients, 62 patients (34.4%) were assisted. Patients in the assisted PD group were older, more likely to be female, more prevalent in DM and CVD, with a higher Charlson score than patients in the self-care PD group (P all < 0.05). In the multivariable analysis, assisted patients had a comparable patient survival and peritonitis-free survival compared to self-care PD patients either in the Cox or in the FG models. According to a Cox model, the use of assisted PD was associated with a lower risk of technique failure (cs-HR 0.20, 95% CI 0.04–0.76), but the association lost its statistical significance in the Fine and Gray model.
Conclusions
No significant difference in patient survival and peritonitis-free survival were found between the assisted PD patients and self-care PD patients. Moreover, assisted PD might protect older patients incapable of self-care from technique failure. Therefore, we suggested that assisted PD could be a safe and effective RRT modality for older ESRD patients who need assistance.