Impact of the magnetic field on 3T3-E1 preosteoblasts inside SMART silk fibroin-based scaffolds decorated with magnetic nanoparticles

Tanasă, Eugenia; Zaharia, Cătălin; Hudiţă, Ariana; Radu, I.; Costache, Marieta; Gălățeanu, Bianca

doi:10.1016/j.msec.2020.110714

Cited by 36 publications

(27 citation statements)

References 70 publications

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“…In this way, a synergy occurs between the nanoparticles and the hydrogel, thus enhancing their use in regenerative medicine. The studies of Tanasa et al (2020) and Shuai et al (2020) follow this line since they are based on the development of scaffolds stimulated with either a magnetic field or a proper magnetic micro-environment [ 50 , 51 ]. The former produced silk-fibroin-based scaffolds with preosteoblasts imbibed, whereas the latter used the magnetic micro-environment for bone regeneration.…”

Section: Freeze-dryingmentioning

confidence: 99%

Polymer-Based Scaffolds for Soft-Tissue Engineering

et al. 2020

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Biomaterials have been used since ancient times. However, it was not until the late 1960s when their development prospered, increasing the research on them. In recent years, the study of biomaterials has focused mainly on tissue regeneration, requiring a biomaterial that can support cells during their growth and fulfill the function of the replaced tissue until its regeneration. These materials, called scaffolds, have been developed with a wide variety of materials and processes, with the polymer ones being the most advanced. For this reason, the need arises for a review that compiles the techniques most used in the development of polymer-based scaffolds. This review has focused on three of the most used techniques: freeze-drying, electrospinning and 3D printing, focusing on current and future trends. In addition, the advantages and disadvantages of each of them have been compared.

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Section: Freeze-dryingmentioning

confidence: 99%

Polymer-Based Scaffolds for Soft-Tissue Engineering

et al. 2020

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“…For example TiO 2 NPs or GO have been used to increase the mechanical resistance of silk sponges and hydrogels (Kim et al, 2016 ; Wang et al, 2020 ). Magnetic NPs have interesting properties that can be used to apply a magnetic stimuli to cells and tissues (Aliramaji et al, 2017 ; Brito-Pereira et al, 2018 ; Tanasa et al, 2020 ). Recently a silk chitosan magnetite bionanocomposite scaffold was prepared by freeze casting (Aliramaji et al, 2017 ).…”

Section: Silk-based Bionanocompositesmentioning

confidence: 99%

Silk Polymers and Nanoparticles: A Powerful Combination for the Design of Versatile Biomaterials

et al. 2020

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Silk fibroin (SF) is a natural protein largely used in the textile industry but also in biomedicine, catalysis, and other materials applications. SF is biocompatible, biodegradable, and possesses high tensile strength. Moreover, it is a versatile compound that can be formed into different materials at the macro, micro- and nano-scales, such as nanofibers, nanoparticles, hydrogels, microspheres, and other formats. Silk can be further integrated into emerging and promising additive manufacturing techniques like bioprinting, stereolithography or digital light processing 3D printing. As such, the development of methodologies for the functionalization of silk materials provide added value. Inorganic nanoparticles (INPs) have interesting and unexpected properties differing from bulk materials. These properties include better catalysis efficiency (better surface/volume ratio and consequently decreased quantify of catalyst), antibacterial activity, fluorescence properties, and UV-radiation protection or superparamagnetic behavior depending on the metal used. Given the promising results and performance of INPs, their use in many different procedures has been growing. Therefore, combining the useful properties of silk fibroin materials with those from INPs is increasingly relevant in many applications. Two main methodologies have been used in the literature to form silk-based bionanocomposites: in situ synthesis of INPs in silk materials, or the addition of preformed INPs to silk materials. This work presents an overview of current silk nanocomposites developed by these two main methodologies. An evaluation of overall INP characteristics and their distribution within the material is presented for each approach. Finally, an outlook is provided about the potential applications of these resultant nanocomposite materials.

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“…As well as collagen, silk fibroin (SF) protein [115] was used to obtain a magneto-responsive scaffold in mixture with poly(2-hydroxyethyl methacrylate) and Fe 3 O 4 MNPs [116]. Silk fibroin and poly(2-hydroxyethyl methacrylate) were synthesized by free radical polymerization technique in the presence of ethylene glycol dimethacrylate acting as cross linker.…”

Section: Mnps Enriched Scaffolds With the Application Of External Magmentioning

confidence: 99%

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

et al. 2020

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The burst of research papers focused on the tissue engineering and regeneration recorded in the last years is justified by the increased skills in the synthesis of nanostructures able to confer peculiar biological and mechanical features to the matrix where they are dispersed. Inorganic, organic and hybrid nanostructures are proposed in the literature depending on the characteristic that has to be tuned and on the effect that has to be induced. In the field of the inorganic nanoparticles used for decorating the bio-scaffolds, the most recent contributions about the paramagnetic and superparamagnetic nanoparticles use was evaluated in the present contribution. The intrinsic properties of the paramagnetic nanoparticles, the possibility to be triggered by the simple application of an external magnetic field, their biocompatibility and the easiness of the synthetic procedures for obtaining them proposed these nanostructures as ideal candidates for positively enhancing the tissue regeneration. Herein, we divided the discussion into two macro-topics: the use of magnetic nanoparticles in scaffolds used for hard tissue engineering for soft tissue regeneration.

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Impact of the magnetic field on 3T3-E1 preosteoblasts inside SMART silk fibroin-based scaffolds decorated with magnetic nanoparticles

Cited by 36 publications

References 70 publications

Polymer-Based Scaffolds for Soft-Tissue Engineering

Polymer-Based Scaffolds for Soft-Tissue Engineering

Silk Polymers and Nanoparticles: A Powerful Combination for the Design of Versatile Biomaterials

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

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