Impact of the nature and concentration of plasticizers on the ability of PVC to sorb drug

Salloum, Hassan Al; Saunier, Johanna; Aymes-Chodur, Caroline; Barakat, Hala; Yagoubi, Najet

doi:10.1016/j.ijpharm.2015.11.004

Cited by 26 publications

(38 citation statements)

References 42 publications

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“…The amount of sorption depends on drug interaction with the plasticised surface of an infusion system. [ 28 ] The diffusion of diazepam into the polymer matrix appeared to be higher than that of isosorbide dinitrate, resulting in more significant sorption behaviour during infusion through the investigated tubes. Deeper insight is required into the interaction of different drug solutions/application set combinations to be able to evaluate the concentration throughout flow time of the active pharmaceutical ingredient over administration time to the patient.…”

Section: Discussionmentioning

confidence: 99%

Influence of a Double-Lumen Extension Tube on Drug Delivery: Examples of Isosorbide Dinitrate and Diazepam

Maiguy-Foinard¹,

Blanchemain

Barthélémy³

et al. 2016

PLoS ONE

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PurposePlastic materials such as polyurethane (PUR), polyethylene (PE), polypropylene (PP) and polyvinyl chloride (PVC) are widely used in double-lumen extension tubing. The purposes of our study were to 1) compare in vitro drug delivery through the double extension tubes available on the market 2) assess the plastic properties of PUR in infusion devices and their impact on drug delivery.MethodsThe study compared eight double-lumen extension tubes in PUR, co-extruded (PE/PVC) plastic and plasticised PVC from different manufacturers. Isosorbide dinitrate and diazepam were used as model compounds to evaluate their sorption on the internal surface of the infusion device. Control experiments were performed using norepinephrine known not to absorb to plastics. Drug concentrations delivered at the egress of extension tubes were determined over time by an analytical spectrophotometric UV-Vis method. The main characteristics of plastics were also determined.ResultsSignificant differences in the sorption phenomenon were observed among the eight double-lumen extension tubes and between pairs of extension tubes. Mean concentrations of isosorbide dinitrate delivered at the egress of double-lumen extension tubes after a 150-minute infusion (mean values ± standard deviation in percentage of the initial concentrations in the prepared syringes) ranged between 80.53 ± 1.66 (one of the PUR tubes) and 92.84 ± 2.73 (PE/PVC tube). The same parameters measured during diazepam infusion ranged between 48.58 ± 2.88 (one of the PUR tubes) and 85.06 ± 3.94 (PE/PVC tube). The double-lumen extension tubes in PUR were either thermosetting (resin) or thermoplastic according to reference.ConclusionsClinicians must be aware of potential drug interactions with extension tube materials and so must consider their nature as well as the sterilisation method used before selecting an infusion device.

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Section: Discussionmentioning

confidence: 99%

Influence of a Double-Lumen Extension Tube on Drug Delivery: Examples of Isosorbide Dinitrate and Diazepam

Maiguy-Foinard¹,

Blanchemain

Barthélémy³

et al. 2016

PLoS ONE

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“…Opioid drugs as morphine, pethidine, or fentanyl are characterized by high Log K values, allowing them to absorb into and through PVC . Our results are disparate but do not indicate a higher migration rate when the tubings are exposed to opioids.…”

Section: Resultsmentioning

confidence: 50%

DinCH and ESBO actual migration from PVC infusion tubings used in an oncopediatric unit

Tortolano

Matmati

Bourhis

et al. 2018

J of Applied Polymer Sci

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Plasticizer leaching from poly(vinyl chloride) (PVC) tubing is a well‐studied phenomenon and is a real issue in medical care today. The present study focuses on the release of two plasticizers 1,2‐cyclohexane dicarboxylic acid diisononyl ester (DINCH) (primary) and epoxidized soy bean oil (ESBO) (secondary) from PVC extension tubings used in an oncopediatric unit. The release of plasticizers is calculated by comparison to unused tubings with the same batch number. Both the DINCH and ESBO ratio diminishes in used versus new extension tubings. The loss of plasticizers has not been related to the presence of a specific drug. Our results confirm the leaching of classic plasticizers like the DINCH and of secondary plasticizers like the ESBO from tubings in real life. It confirms too the existence of a complex phenomenon in which exchanges between drugs, lipids, PVC matrices, and the administration sequences can change the global release of plasticizers. Considering all the variables involved in real‐life data, the in vitro testing appears to be the most efficient way to confirm these observations. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46649.

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“…[ 10 , 11 ] The material of an administration set can also influence on the effect of the drug. [ 1 , 2 ]…”

Section: Discussionmentioning

confidence: 99%

“…The risk of drug sorption into the administration set has been well documented. [ 1 – 3 ] Drug sorption can influence the prognosis of patients by preventing them from receiving the physician-intended drug dosage. Nitroglycerin is a nitrate used for vasodilation in patients with hypertension and ischemic heart disease.…”

Section: Introductionmentioning

confidence: 99%

A comparison of the pharmacokinetic and pharmacodynamic properties of nitroglycerin according to the composition of the administration set

Kim

Song²,

Min

et al. 2018

Medicine

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Background:There is a risk of drug sorption into an intravenous administration set composed of polyvinyl chloride (PVC), polyurethane (PU), or polyolefin (PO). This has implications on the dose of the active ingredient the patient receives, and thus therapeutic success. This study aimed to determine the plasma concentration of nitroglycerin and the effect of nitroglycerin on patients based on the composition of the administration set.Methods:Using a randomized, open-labeled, 3 × 3 crossover method, 9 volunteers were assigned to 3 groups. In period I, nitroglycerin (100 μg/mL) was infused via a PVC- (group A), PU- (group B), or PO-based (group C) administration set. In period II, PU- (group A), PO- (group B), and PVC-based (group C) administration sets were used, and in period III, PO- (group A), PVC- (group B), and PU-based (group C) administration sets were used. The rate of drug administration in all periods was 12 mL/hour for 30 minutes using an infusion pump. Blood samples were collected, and the plasma concentrations of nitroglycerin were analyzed using validated high-performance liquid chromatography coupled with tandem mass spectrometry. Blood pressure was determined using a sphygmomanometer applied to the other upper arm at an interval of 5 minutes.Results:We observed that the mean plasma concentration of nitroglycerin over time when administered using a PO-based tube was higher than that when using a PU- or PVC-based tube. When the percent change of the mean arterial pressure from baseline at each time point was compared among groups, there were statistically significant differences between PU and PO or PVC at most points during nitroglycerin infusion.Conclusion:Our results showed higher nitroglycerin plasma concentration and lower arterial pressure when a PO-based administration set was used than when a PVC- or PU-based administration set was used. PO-based administration sets may be more appropriate for nitroglycerin administration compared to those composed of PVC or PU.

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Impact of the nature and concentration of plasticizers on the ability of PVC to sorb drug

Cited by 26 publications

References 42 publications

Influence of a Double-Lumen Extension Tube on Drug Delivery: Examples of Isosorbide Dinitrate and Diazepam

Influence of a Double-Lumen Extension Tube on Drug Delivery: Examples of Isosorbide Dinitrate and Diazepam

DinCH and ESBO actual migration from PVC infusion tubings used in an oncopediatric unit

A comparison of the pharmacokinetic and pharmacodynamic properties of nitroglycerin according to the composition of the administration set

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