Impact of the novel coronavirus infection (COVID-19) experienced by pregnant women on the health of newborns

Kosolapova, Kosolapova Yu.A.; Boris, Boris D.A.; Poludenko, Poludenko N.D.; M, Makieva M.I. Makieva; Nikitina, Nikitina I.V.; Inviyaeva, Inviyaeva E.V.; Vtorushina, Vtorushina V.V.; Krechetova L, Krechetova L.V.; Mikhanoshina, Mikhanoshina N.V.; Zubkov, Zubkov V.V.; Degtyarev, Degtyarev D.N.

doi:10.18565/aig.2022.11.90-98

Cited by 2 publications

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“…На сегодняшний день имеется достаточно публикаций об инфицировании коронавирусом SARS-CoV-2 беременных и их детей [15][16][17]1]. По данным источников, частота перинатальных осложнений и малых аномалий и пороков развития (гидронефроз, неонатальная гипогликемия) у детей, рожденных у женщин с COVID-19, зависит от срока беременности и наблюдается чаще у детей, которые родились в первом триместре, а частота инфекционно-воспалительных заболеваний и увеличение риска преждевременных родов оказываются выше у детей, чьи матери перенесли SARS-CoV-2 в третьем триместре [15,18].…”

Section:  обсуждениеunclassified

Diagnosis of Auditory Function in Infants with COVID-19 (Part I)

Рахманова,

Матроскин,

Кругляков

et al. 2024

Оториноларингология. Восточная Европа

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Цель. Выявить возможное влияние вируса SARS-CoV-2 на слуховую функцию детей первого года жизни. Материалы и методы. Проведен анализ слуховой функции 100 детей, рожденных от матерей, перенесших COVID-19 во время беременности и переболевших самостоятельно в течение первого года жизни, а также эпикризов историй болезни самих матерей и их детей. Работа носила ретроспективно-проспективный характер и состояла из 2 этапов. На первом этапе изучали выписные эпикризы историй болезни детей и их матерей, а на втором – проводили всем детям аудиологическое обследование методом слуховых вызванных потенциалов, отоакустической эмиссии и тимпанометрии. Полученные нами данные обрабатывали различными статистическими методами с применением кластеризации на основе искусственной нейронной сети Кохонена и процедуры жесткой кластеризации по возрасту на момент обследования с последующим анализом получившихся кластеров. Результаты. Анализ слуховой функции в момент обращения показал отсутствие регистрации вызванной отоакустической эмиссии у 27 детей, из них 10 были доношенными и 17 недоношенными. У 17 из 27 пациентов, что составляет 17% от общего числа детей, была выявлена нейросенсорная тугоухость, а именно: двусторонняя – у 12 детей, односторонняя – у 1 ребенка и двусторонняя глухота – у 4 детей. Проведенный кластерный анализ выявил более худшие показатели параметров вызванной отоакустической эмиссии и слуховых вызванных потенциалов в группе, где мамы переболели COVID-19 во время беременности, чем в группе, где болели сами дети. Заключение. Выявленные в нашей работе случаи заболевания детей с нейросенсорной тугоухостью косвенно, а также результаты кластерного анализа могут свидетельствовать о возможном прямом влиянии вируса SARS-CoV-2 на те или иные структуры слухового анализатора. Purpose. Identify the possible influence of the SARS-CoV-2 virus on the auditory function of children of the first year of life. Materials and methods. An analysis of the auditory function of 100 children born to mothers who had undergone COVID-19 during pregnancy and had recovered independently during the first year of life, as well as epicrises of case histories of the mothers themselves and their children, was carried out. The work was retrospective prospective and consisted of 2 stages. At the first stage, discharge epicrises of case histories of children and their mothers were studied, and at the second stage, audiological examination was carried out for all children by the method of auditory induced potentials, otoacoustic emission and tympanometry. The data we obtained were processed by various statistical methods using Cohonen artificial neural network-based clustering and a rigid clustering procedure by age at the time of examination, followed by analysis of the resulting clusters. Results. Analysis of auditory function at the time of treatment showed that there was no record of induced otoacoustic emission in 27 children, of whom 10 were full-term and 17 premature. In 17 of the 27 children, 17% of the total number of children, sensorineural stiffness was detected, namely, bilateral in 12 children, unilateral in one child and bilateral deafness in 4 children. The cluster analysis revealed worse parameters of induced otoacoustic emission and auditory induced potentials in the group where mothers had COVID-19 during pregnancy than in the group where the children themselves were sick. Conclusion. The cases of children with sensorineural hearing loss identified in our work indirectly, as well as the results of cluster analysis, may indicate a possible direct effect of the SARS-CoV-2 virus on certain structures of the auditory analyzer.

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Section:  обсуждениеunclassified

Diagnosis of Auditory Function in Infants with COVID-19 (Part I)

Рахманова,

Матроскин,

Кругляков

et al. 2024

Оториноларингология. Восточная Европа

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Features of lymphocyte subset composition in neonates born to mothers suffered from COVID-19 at different stages of pregnancy

Inviyaeva

Kosolapova

Кречетова

et al. 2023

Russian Journal of Infection and Immunity

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The relationship between the incidence of COVID-19 in pregnant women who have had a coronavirus infection at different gestational ages and the health status of paired neonates is of great interest. However, no sufficient convincing data fully reflecting features of subsequent neonatal period, the state of the immune system in this category of children, affecting characteristics of postnatal period have been accumulated. Based on this, it underlies the relevance of the current study aimed at investigating parameters of clinical and immunological state of neonatal health after paired mothers recovered from COVID-19 at different gestational ages. The prospective study included 131 women and 132 children. The main group consisted of women (n = 61) who had COVID-19 during pregnancy and paired newborns (n = 62) at gestational age (GA) of 3741 weeks, the comparison group women without laboratory-confirmed COVID-19 during pregnancy (n = 70) and paired newborns (n = 70) of similar gestational age. While analyzing the anamnesis of the patients, no significant differences in somatic and obstetric-gynecological diseases were found. Analyzing course of pregnancy revealed that low molecular weight heparins were significantly more often applied in the main group. The term and frequency of delivery by caesarean section in pregnant women in the main group did not significant differ from that of the control group. No significant difference in the frequency of causes accounting for the severity of the condition of neonates in paired mothers with COVID-19 at different trimester of gestation was found. Investigating lymphocyte subset composition, neutrophil phagocytic activity, and IgG class antibodies specific to SARS-CoV-2 was carried out. It was found that lymphocyte subset profile in newborns from paired mothers with COVID-19 at different trimesters of gestation differed only in the level of NK cells (CD56+) in children born to mothers recovered from COVID-19 in the first trimester. In this study, in general, no severe perinatal outcomes in newborns from paired mothers with COVID-19 during pregnancy were documented. No cases of moderate or severe maternal COVID-19 were observed. Therefore, further prospective studies are needed to assess an impact of COVID-19 severity on maternal and fetal birth outcomes and clarify optimal management of pregnant women in such cases.

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Impact of the novel coronavirus infection (COVID-19) experienced by pregnant women on the health of newborns

Cited by 2 publications

References 0 publications

Diagnosis of Auditory Function in Infants with COVID-19 (Part I)

Diagnosis of Auditory Function in Infants with COVID-19 (Part I)

Features of lymphocyte subset composition in neonates born to mothers suffered from COVID-19 at different stages of pregnancy

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