“…In this issue of IJC Heart & Vasculature, Kobo et al [3] evaluated the clinical outcomes of patients undergoing PCI for either ACS or CCS within the prospective and multicentric e-Ultimaster registry, categorizing them into four groups based on the presence of SMuRFs - none, 1, 2, 3 or 4 -. The study's primary endpoint was target lesion failure (TLF), a composite of cardiac death, target vessel-related myocardial infarction or clinically driven target lesion revascularization at 1-year.…”