2023
DOI: 10.3389/fpubh.2023.1238502
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Impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in Gipuzkoa, northern Spain, 1998–2022

Ayla Manzanal,
Diego Vicente,
Marta Alonso
et al.

Abstract: ObjectivesTo analyze the impact of pneumococcal conjugate vaccines (PCVs) on the incidence of invasive pneumococcal diseases (IPDs) and pneumococcal antibiotic resistance in Gipuzkoa, northern Spain for a 25 years period.MethodsAll cases of IPD confirmed by culture between 1998 and 2022 in a population of around 427,416 people were included. Pneumococci were serotyped and antimicrobial susceptibility was assessed by the EUCAST guidelines.ResultsOverall, 1,516 S. pneumoniae isolates were collected. Annual IPD i… Show more

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