Impact of the SARS-Cov-2 Virus Pandemic on Children and Adults with Congenital Heart Disease: Its Burden and Risk Factors

Jairo, Araujo John

doi:10.23937/2378-2951/1410190

Cited by 1 publication

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6,[9][10][11] Previous reports suggest age, obesity, type 1 diabetes, genetic disorders, immunosuppression, chronic pulmonary disease, and Latino, Hispanic, or Black racial or ethnic identification may place paediatric and young adult patients at higher risk for more severe illness and hospitalisation. 7,[10][11][12][13][14][15] While clinical evidence suggests that underlying cardiovascular disease increases the risk for severe coronavirus disease 2019 illness, hospitalisation, and death in adult patients, [16][17][18] clarity on the role of underlying congenital heart disease and other paediatric-onset chronic cardiovascular conditions has been slower to emerge. While several studies of mostly adult patients with underlying congenital heart disease showed very rare hospitalisations and deaths due to coronavirus disease 2019 infection, 19,20 more recent data from a large database of over 800 hospitals in the United States found an association between diagnostic codes for congenital cardiac and circulatory anomalies and increased risk of severe disease and hospitalisation in patients under 18 years of age.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and outcomes of acute COVID-19 infection in paediatric and young adult patients with underlying cardiac disease

Fisher

Badran

et al. 2021

Cardiol Young

View full text Add to dashboard Cite

Objective To describe outcomes of acute coronavirus disease 2019 in paediatric and young adult patients with underlying cardiac disease and evaluate the association between cardiac risk factors and hospitalisation. Study design We conducted a retrospective single-institution review of patients with known cardiac disease and positive severe acute respiratory syndrome coronavirus 2 RT-PCR from 1 March, 2020 to 30 November, 2020. Extracardiac comorbidities and cardiac risk factors were compared between those admitted for coronavirus disease 2019 illness and the rest of the cohort using univariate analysis. Results Forty-two patients with a mean age of 7.7 ± 6.7 years were identified. Six were 18 years of age or more with the oldest being 22 years of age. Seventy-six percent were Hispanic. The most common cardiac diagnoses were repaired cyanotic (n = 7, 16.6%) and palliated single ventricle (n = 7, 16.6%) congenital heart disease. Fourteen patients (33.3%) had underlying syndromes or chromosomal anomalies, nine (21%) had chronic pulmonary disease and eight (19%) were immunosuppressed. Nineteen patients (47.6%) reported no symptoms. Sixteen (38.1%) reported only mild symptoms. Six patients (14.3%) were admitted to the hospital for acute coronavirus disease 2019 illness. Noncardiac comorbidities were associated with an increased risk of hospitalisation (p = 0.02), particularly chronic pulmonary disease (p = 0.01) and baseline supplemental oxygen requirement (p = 0.007). None of the single ventricle patients who tested positive required admission. Conclusions Hospitalisations for coronavirus disease 2019 were rare among children and young adults with underlying cardiac disease. Extracardiac comorbidities like pulmonary disease were associated with increased risk of hospitalisation while cardiac risk factors were not.

show abstract