Impact of the Sofia® Influenza A+B FIA rapid diagnostic test in a pediatric emergency department

Diallo, D.; Hochart, Audrey; Lagrée, M.; Dervaux, B.; Martinot, A.; Dubos, François

doi:10.1016/j.arcped.2018.10.004

Cited by 9 publications

(9 citation statements)

References 24 publications

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“…The identification of a viral etiology can reduce unnecessary investigations and promote antibiotic stewardship. However, this diagnostic approach is expensive, and its utility and contributions need to be further evaluated [24] .…”

Section: Discussionmentioning

confidence: 99%

Rapid syndromic testing for respiratory viral infections in children attending the emergency department during COVID-19 pandemic in Lille, France, 2021–2022

Ouafi¹,

Dubos²,

Engelman³

et al. 2022

Journal of Clinical Virology

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Section: Discussionmentioning

confidence: 99%

Rapid syndromic testing for respiratory viral infections in children attending the emergency department during COVID-19 pandemic in Lille, France, 2021–2022

Ouafi¹,

Dubos²,

Engelman³

et al. 2022

Journal of Clinical Virology

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“…On the other hand, influenza-confirmed patients had less additional visits in primary care because the expected evolution of disease can be better explained to the family based on the certainty of an objective test. The additional visits for the same process make an important difference as the healthcare system is usually under pressure due to the high number of consultations during the influenza season ( 15 , 16 ).…”

Section: Discussionmentioning

confidence: 99%

The Importance of Rapid Influenza Testing in Pediatric Primary Care: Experience During Three Consecutive Influenza Seasons (2016–2019) in Barcelona (Catalonia, Spain)

Esso¹,

Vilà²,

Andrés

et al. 2020

Front. Pediatr.

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Clinical diagnosis of influenza has low sensitivity in infants and children. Signs and symptoms are non-specific and similar to those of other respiratory viruses. Rapid influenza diagnostic tests (RIDTs) with adequate sensitivity and specificity used at the point of care can be useful for an etiologic diagnosis of influenza in primary care. This should have an impact on better management of these patients. We conducted a study during three consecutive influenza seasons (2016–2017, 2017–2018, and 2018–2019) in pediatric primary care settings collecting data from influenza point-of-care tests (POCTs)-confirmed ≤ 6-year-old patients. During the first two influenza seasons, antibiotic prescriptions and additional visits from influenza POCT-confirmed patients (Group_1) were compared to patients with influenza-like illness (ILI) (Group_2), or fever (2016 ICD-10 code R50) with no other signs of influenza (Group_3). Group_1 had 0.19 (2016–2017) and 0.23 (2017–2018) additional visits compared to 0.48 (2016–2017) and 0.49 (2017–2018) Group_2 p < 0.001 and 1.01 (2016–2017) and 0.80 (2017–2018) Group_3 p < 0.001. Antibiotic prescription was lower in Group_1 (10.2%) vs. Group_3 (17.2%) p < 0.002, difference statistically significant only for the 2017–2018 season. During the third season (2018–2019), RIDTs results were transmitted in real time to the reference laboratory ia the cloud, which strengthens the monitoring of circulating influenza viruses in the community. In our experience, the use of POCTs has a great potential in primary care specially in infants and young children in which the diagnosis maybe missed due to non-specific signs and symptoms.

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“…From the literature, we also identified 4 budget impact analyses for authorized POCTs in Canada. 56,57,75,76 The budget impact analyses reported the following findings:…”

Section: How Much Does It Cost?mentioning

confidence: 98%

“…54 The respiratory clinic needed to send samples to an offsite laboratory, whereas other units assessed could send their samples to an onsite laboratory. 54 Other studies found that POCTs for influenza\can reduce the CADTH Horizon Scan treatment prescribed (e.g., antivirals), [54][55][56] follow up tests for patients, 56,57 and hospital admissions and length of stay. 54,56,57 However, we did not identify any studies assessing patient outcomes in care settings in Canada.…”

Section: How Do Pocts Change Care For Influenza and Covid-19?mentioning

confidence: 99%

Point-of-Care Tests for COVID-19 and Influenza in Canada

CADTH

2024

cjht

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What Is the Issue? Health care providers rely on laboratory tests to differentiate between respiratory illnesses that manifest in similar symptoms, such as COVID-19 and influenza. However, samples may travel to centralized laboratories to process, delaying test results and treatment. Point-of-care tests (POCTs) allow for diagnosis at the site of care but at the expense of diagnostic performance. Several commercial POCTs, specifically for COVID-19, have become increasingly available in Canada since the start of the pandemic. Decision-makers will need to consider which commercial POCT can meet their jurisdiction’s testing needs. POCTs in Canada and their Potential Impact Some POCTs, called “Multiplex tests,” can detect and differentiate between certain illnesses using a single sample. Some studies suggest that using POCTs for respiratory illness in hospitals and emergency departments can expedite diagnosis, improve patient flow, reduce admissions, and shorten the length of stay. Commercial POCTs vary in diagnostic performance, complexity, and costs. There are at least 37 authorized POCTs for COVID-19, influenza, or both in Canada. All devices accept a nasal, nasopharyngeal sample, or both sample types for testing. Some tests require a reader or analyzer to use test kits for diagnosis. POCTs can provide results in 1 hour or less. However, laboratory testing (i.e., nucleic acid amplification tests) remains the standard of care to diagnose COVID-19 and influenza, given their better diagnostic performance compared to POCTs. What Else Do We Need to Know? Confirmatory laboratory tests can reaffirm the diagnosis from POCTs. However, budget impact analyses and clinical studies on authorized tests in Canada do not consider how confirmatory lab tests impact findings on POCT use. Future studies should investigate the cost-effectiveness of POCTs with confirmatory testing, as well as the impact of incorrect diagnosis from POCT on patient outcomes. Rural and remote communities may benefit from POCTs for respiratory illness, given their distance to centralized laboratories.

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Impact of the Sofia® Influenza A+B FIA rapid diagnostic test in a pediatric emergency department

Cited by 9 publications

References 24 publications

Rapid syndromic testing for respiratory viral infections in children attending the emergency department during COVID-19 pandemic in Lille, France, 2021–2022

Rapid syndromic testing for respiratory viral infections in children attending the emergency department during COVID-19 pandemic in Lille, France, 2021–2022

The Importance of Rapid Influenza Testing in Pediatric Primary Care: Experience During Three Consecutive Influenza Seasons (2016–2019) in Barcelona (Catalonia, Spain)

Point-of-Care Tests for COVID-19 and Influenza in Canada

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