PurposeThis paper takes the current COVID-19 pandemic raging around the world as a realistic background and uses the informal scientific communication mode in social media as the theoretical basis. It aims to explore the characteristics and rules of scientific communication in social media under emergency events, grasp the potential and risks of scientific communication in social media in special times and provide a perspective of academic communication for the scientific response.Design/methodology/approachThe authors select the enumeration data of the early COVID-19 theme papers spread on social media networks as the research object, apply descriptive statistical analysis to the basic statistical distribution of variables and use factor analysis and visualization methods to explore the law and characteristics of the spread of scientific papers on social media platforms.FindingsIt was found that users of the COVID-19 paper are mainly in North America, Europe and South America, followed by those in East Asia, Southeast Asia and Oceania. The users are mainly public figures, doctors and other practitioners, science communicators and scientists. The process of social media communication reflects three ways of knowledge construction, social interaction and academic communication, and there are three ways of communication law and changing trend of cross transition and integration.Originality/valueThis study observes the function and role of science communication in social media in a special period from a unique perspective of academic communication, so as to promote academic means to fight against the epidemic.