Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy:a clinical trial for oral hygiene and oral condition

Moriyama, Shigeharu; Hinode, Daisuke; Yoshioka, Masami; Sogawa, Yuka; Nishino, Takeshi; Tangoku, Akira; Grenier, Daniel

doi:10.2152/jmi.65.184

Cited by 13 publications

(14 citation statements)

References 25 publications

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“…Tongue coating samples were also used to quantify periodontopathogenic bacteria ( F. nucleatum ) by quantitative PCR as previously reported by Moriyama et al (Moriyama et al, ) with slight modifications. The MiniOpticon system (Bio‐Rad Laboratories, Hercules, CA, USA) with SYBR Green I dye was used for the quantitative PCR analysis.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of an oral care tablet containing kiwifruit powder in reducing oral bacteria in tongue coating: A crossover trial

Matsumura

Hinode

Fukui

et al. 2019

Clinical & Exp Dental Res

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Objectives The aim of this study was to investigate the effect of an oral care tablet containing kiwifruit powder on oral bacteria in tongue coating compared with tongue brushing. Material and methods Thirty‐two healthy, young adults were enrolled, and a crossover clinical trial was conducted. The volatile sulfur compound (VSC) concentration, Winkel tongue‐coating index (WTCI), and the number of total bacteria in addition to Fusobacterium nucleatum in tongue coating were measured. We instructed subjects to remove tongue coating by tongue brush for Intervention I, to keep the oral care tablet containing kiwifruit powder on the tongue dorsum and to let it dissolve naturally for Intervention II, and three oral care tablets 1 day before the measurement for Intervention III. Results There were significant differences in terms of the level of H2S, VSC, and WTCI at Intervention I and all evaluation values at Intervention II. There were significant differences in terms of the level of H2S, VSC, WTCI, the number of total bacteria, and F. nucleatum at Intervention III. The value of WTCI, the number of bacteria, and F. nucleatum decreased significantly after taking the oral care tablets than after tongue brushing. When compared with Interventions I and III, Intervention III showed the effective results; there were significant differences in the number of total bacteria and F. nucleatum between tongue brushing and taking tablets. Conclusions These results suggested that the oral care tablet containing kiwifruit powder could be effective in reducing total bacteria and F. nucleatum in tongue coating when compared with tongue brushing.

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Section: Methodsmentioning

confidence: 99%

Effectiveness of an oral care tablet containing kiwifruit powder in reducing oral bacteria in tongue coating: A crossover trial

Matsumura

Hinode

Fukui

et al. 2019

Clinical & Exp Dental Res

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“…Many TCM formulas were proven to be able to enhance the anti-tumor effect by regulating cell cycle and apoptosis, [26][27][28] and reduce the side effects of chemotherapies. [29][30][31] However, recent literatures and case reports have found herbal medicines as common implicated agents causing liver injury. [3][4][5]32,33 Therefore, consideration of TCM as causative agents as well as reviewing TCM formula compositions should be included in clinical evaluation.…”

Section: Discussionmentioning

confidence: 99%

A simple method to identify undiagnosed drug-induced liver injury (DILI) and its application in oncology pharmacy practice

Wen

et al. 2019

J Oncol Pharm Pract

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Aims To establish a simple method to identify chemotherapy-induced liver injury among oncological patients. To evaluate current clinical approach to elevated laboratory liver test results. Methods A total of 289 patients admitted to oncology department who had systemic chemotherapy episodes for cancer treatment from 1 January 2017 to 31 December 2017 were identified. With aid of healthcare information system, Hy's law was applied to laboratory liver test results to identify potential hepatocellular drug-induced liver injury cases. Medical record review was carried out among identified patients to exclude liver dysfunction of alternative causes. Current clinical approach to elevated laboratory liver tests was evaluated through medical record review. Results Of 289 patients who were treated by systemic chemotherapies, there were 123 patients with elevated laboratory liver tests, among which 8 patients were suspected as potential Hy's law cases. After medical record review, there were two patients determined with chemotherapy-associated liver injury, caused by 5-fluorouracil, leucovorin, irinotecan, and S-1 plus paclitaxel separately. Of eight potential Hy's law cases, seven (87.5%) patients were prescribed with ≥2 kinds of liver protectants and remained treated with traditional Chinese medicine for decoction. Conclusions A reliable and simple method to identify undiagnosed drug-induced liver injury was successfully established. An annual incidence of 0.69% of chemotherapy-associated liver injury in oncology department of the setting was found.

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“…This leads to the suggestion that TJ-41 could be used to treat oral mucositis in patients receiving chemotherapy [71]. A clinical study confirms that TJ-84 improves mucositis in esophageal cancer patients treated with chemotherapy [61].…”

Section: Tj-84mentioning

confidence: 97%

“…Daiokanzoto (DKT; also called da-huang-gan-cao-tang or TJ-84) is a Kampo medicine that is composed of crude extracts of rhubarb rhizomes and Glycyrrhiza roots. TJ-84 is mainly investigated for use on peptic ulcers, hepatitis C, and pulmonary and skin diseases [58][59][60][61]. Wang et al study the chemical constituents in TJ-84, using the combination of LC-ESI-Q-TOF-MS and LC-ESI-IT-MS, and identify 104 compounds [62].…”

Section: Tj-84mentioning

confidence: 99%

Recent Advances in Glycyrrhiza glabra (Licorice)-Containing Herbs Alleviating Radiotherapy- and Chemotherapy-Induced Adverse Reactions in Cancer Treatment

Wang

Chen

et al. 2022

Metabolites

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Cancers represent a significant cause of morbidity and mortality worldwide. They also impose a large economic burden on patients, their families, and health insurance systems. Notably, cancers and the adverse reactions to their therapeutic options, chemotherapy and radiotherapy, dramatically affect the quality of life of afflicted patients. Therefore, developing approaches to manage chemotherapy- and radiotherapy-induced adverse reactions gained greater attention in recent years. Glycyrrhiza glabra (licorice), a perennial plant that is one of the most frequently used herbs in traditional Chinese medicine, has been heavily investigated in relation to cancer therapy. Licorice/licorice-related regimes, used in combination with chemotherapy, may improve the adverse effects of chemotherapy. However, there is little awareness of licorice-containing herbs alleviating reactions to radiotherapy and chemotherapy, or to other induced adverse reactions in cancer treatment. We aimed to provide a descriptive review, and to emphasize the possibility that licorice-related medicines could be used as an adjuvant regimen with chemotherapy to improve quality of life (QoL) and to reduce side effects, thus, improving compliance with chemotherapy. The experimental method involved searching different databases, including PubMed, the Cochrane Library, and Wang Fang database, as of May 2022, to identify any relevant studies. Despite a lack of high-quality and large-scale randomized controlled trials, we still discovered the potential benefits of licorice-containing herbs from published clinical studies. These studies find that licorice-containing herbs, and their active ingredients, reduce the adverse reactions caused by chemotherapy and radiotherapy, and improve the QoL of patients. This comprehensive review will serve as a cornerstone to encourage more scientists to evaluate and develop effective Traditional Chinese medicine prescriptions to improve the side effects of chemotherapy and radiation therapy.

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Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy:a clinical trial for oral hygiene and oral condition

Cited by 13 publications

References 25 publications

Effectiveness of an oral care tablet containing kiwifruit powder in reducing oral bacteria in tongue coating: A crossover trial

Effectiveness of an oral care tablet containing kiwifruit powder in reducing oral bacteria in tongue coating: A crossover trial

A simple method to identify undiagnosed drug-induced liver injury (DILI) and its application in oncology pharmacy practice

Recent Advances in Glycyrrhiza glabra (Licorice)-Containing Herbs Alleviating Radiotherapy- and Chemotherapy-Induced Adverse Reactions in Cancer Treatment

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