Impact of Thyroidectomy in BMI and Some Biochemical Markers related with Bone Turnover in Hypothyroidism Women

Hussain, Batool Ibrahim; Al-Harbi, Hussein Jasim; Adil, Maysaa

doi:10.5958/0974-360x.2019.00105.7

Cited by 5 publications

(2 citation statements)

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“…In this study TC genotype was associated with high CT and CYP4501A1 levels which may be due to the changes in thyroid function in hypothyroidism patients can affect the osteomineral metabolism causing changes in the dynamics of calcitonin secretion [21] and there was another explanation that in this study allele C which has a significant association with hypothyroidism may be effective on the target genes for calcitonin and CYP4501A1 expression. In the previous study, total thyroidectomy could cause a significant increase in BMI and a significant decrease in thyroid hormones, OPN and calcium levels in Iraqi hypothyroid women [22].…”

Section: Discussionmentioning

confidence: 83%

The Association of TSHR Gene rs2268458 Polymorphism with Hypothyroidism in Females of Babylon Province-Iraq

Hussain

Hadi

Al-Harbi

2018

JUBPAS

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The Aim: To evaluate the association of TSHR gene polymorphism rs2268458 with some Physio-biochemical parameters among hypothyroidism women. Methods: This study included 51 hypothyroidism women and 43 healthy women as a control group. Some Physio-biochemical (body mass index (BMI), cytochrome 450 1A1 (CYP1A1), calcium, and phosphorus) and hormonal assay (Osteopontin (OPN), thyroid stimulating hormone (TSH), fT3, fT4 and Calcitonin (CT)) assay were performed. Genotyping of rs-2268458 of TSHR gene was carried out using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) technique. Results: TSHR rs2268458 was associated with hypothyroidism in Iraqi women and allele C can be a risk factor for disease by OR= 4.393, CI=1.42-13.53 where TC and CC genotypes were associated with high BMI, while TC genotype was associated with high calcitonin and CYP1A1 levels. Conclusion: The TSHR rs2268458 polymorphism was associated with hypothyroidism in Iraqi women and allele C can be a risk factor for some Physio-biochemical and hormonal disorder in hypothyroidism women.

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Section: Discussionmentioning

confidence: 83%

The Association of TSHR Gene rs2268458 Polymorphism with Hypothyroidism in Females of Babylon Province-Iraq

Hussain

Hadi

Al-Harbi

2018

JUBPAS

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“…While the morbidity and mortality rates associated with thyroidectomy are relatively low, there are persistent long-term postoperative complications that continue to pose substantial health and social challenges for patients that affect their quality of life. Studies have shown that thyroidectomy can impact bone metabolism, thyroid hormone levels, and body mass index, especially in hypothyroid patients, highlighting the intricate relationship between the thyroid gland, hormones, and overall physiological functions [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Thyroidectomy and Lobectomy on Patients’ Health-Related Quality of Life, Eastern Region, Saudi Arabia

AlOsaif,

Al Bisher,

Elshnawie

et al. 2024

Clinics and Practice

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Introduction: The thyroid gland is a crucial endocrine organ that can be susceptible to various pathological conditions, often necessitating total thyroidectomy or lobectomy. It is a common surgical procedure in Saudi Arabia. Thus, it is essential to recognize the impact of thyroid surgery on patients’ health-related quality of life (HRQoL). Aim: The aim of this study was to evaluate HRQoL among patients with benign and malignant thyroid diseases who underwent thyroidectomy in the eastern region of Saudi Arabia. Methods: This cross-sectional study was conducted at King Fahad Hospital of University in Khobar, Kingdom of Saudi Arabia from January 2018 to May 2018. The data collection method used was divided into two parts. Part I included the patients’ socio-demographic characteristics and the clinical characteristics of their thyroid surgery. Part II was a HRQoL questionnaire (SF-36, version 1.0). Results: The sample included 100 thyroidectomy patients ≥18 years. The study findings revealed that the overall scores for post-thyroidectomy patients showed a significant improvement in HRQoL, and HRQoL was not significantly associated with benign or malignant thyroid diseases. Conclusion: Especially when the surgery is performed by a high-volume endocrine surgeon, thyroidectomy may lead to significant improvements in HRQoL among patients, including the elderly and younger adults, with benign and malignant thyroid disorders. There was no difference in HRQoL between patients who underwent total thyroidectomy or thyroid lobectomy. Also, HRQol among thyroidectomy patients is associated with their educational and occupational statuses.

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Biochemical study on Anti Thyroid Peroxidase Antibody Enzyme in Serum Blood of women with Thyroid Disease

Shaker

Younis

2023

RJPT

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The research involved study the relation between thyroid peroixdase (TPO) and some of the measured biochemical parameters related to the disease (Triiodothyhyronin T3, Thyroxine T4, Thyroid stimulating hormone TSH, glucosee, vitamin D, calcium, uric acid, albumin, alkaline phosphatase enzyme (ALP), transamination enzymes GOT and GPT)in serum blood patients compared with control group, the reasult demonstration is a significant increase in the mean of TPO enzyme (112.63±69.5 Iu/ml), (273.9±235.1 Iu/ml)in hyperthyroidism and hypothyroidism patient respectively compared with mean in control group was ( 33.9 ±18.99 Iu/ml), also the results showed the significant increase in the concentration of T3, glucose, ALP, GOT, GPT enzymes and non significant increase inT4, uric acid, while a significant decrease in TSH, vitamin D, calcium, and non significant decrease with albumin in hyperthyroidism while the results had been shown a significant increase in TSH, glucose, ALP and non-significant increase in uric acid, GOT, GPT enzymes and a significant decrease in T4, vitamin D, calcium, non- significant decrease in T3, albumin in hypothyroidism . Correlation coefficient of TPO enzyme with these clinical parameters showed a negative significant correlation with GPTenzyme in hyperthyroidism and vitamin D, calcium in hypothyroidism while the results showed that there is no significant relationship of TPO enzyme with the rest of boichemical parameters conclusion of this study was that anti-TPO enzyme is diagnosis of autoimmune thyroid disorders and TPO enzyme is plays an important role in making thyroid hormones

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Impact of Thyroidectomy in BMI and Some Biochemical Markers related with Bone Turnover in Hypothyroidism Women

Cited by 5 publications

References 0 publications

The Association of TSHR Gene rs2268458 Polymorphism with Hypothyroidism in Females of Babylon Province-Iraq

The Association of TSHR Gene rs2268458 Polymorphism with Hypothyroidism in Females of Babylon Province-Iraq

The Impact of Thyroidectomy and Lobectomy on Patients’ Health-Related Quality of Life, Eastern Region, Saudi Arabia

Biochemical study on Anti Thyroid Peroxidase Antibody Enzyme in Serum Blood of women with Thyroid Disease

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