Impact of Time-Resricted Feeding and Aerobic Exercise Combination on Promotes Myokine Levels and Improve Body Composition in Obese Women

Sari, Afdhalia Rahma; Risdayanto, Rifat Danendra; Pradipta, Mohammad Haidar; Qorni, Uais Al; Rejeki, Purwo Sri; Argarini, Raden; Halim, Shariff; Pranoto, Adi

doi:10.47197/retos.v53.102429

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…Irisin is an adipo-myokine secreted mainly by myocytes after skeletal muscle contraction (Waseem et al, 2022;Colpitts et al, 2022). Muscle contraction leads to activation of peroxisome proliferator-activated receptorgamma coactivator (PGC-1α), which in turn increases fibronectin type III domain-containing protein 5 (FNDC5) gene expression (Sari et al, 2024). The cleavage of this polypeptide protein at the N-terminus is known as irisin hormone (Boström et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Treadmill has a more beneficial effect than cycling on fat loss through myokines secretion in obese women

Setiawan,

Rejeki,

Pranoto

et al. 2024

Retos

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Obesity is a condition characterized by the excessive accumulation of body fat beyond normal limits. Irisin and IL-6 are myokines that have a function to convert white adipose tissue into brown adipose tissue, resulting in thermogenesis that induces energy expenditure and has implications for reducing excess fat accumulation. This study aims to demonstrate the response of moderate-intensity treadmill and ergo cycle exercise on fat loss and increasing myokines secretion in obese adolescent females. A total of 30 obese women met the criteria with body mass index (BMI) of 30.02±2.97 kg/m2, age 21.27±1.31 years were recruited into the study and given single session of aerobic ergo cycle exercise (AEEG) and aerobic treadmill exercise (ATEG) during 45 min. Measurement of myokines, i.e., irisin and IL-6, using Enzyme-Linked Immunosorbent Assay (ELISA) on all samples. Statistical analysis was performed using a one-way ANOVA test and Tukey's HSD post hoc test with significance at the 5% level. The results showed that the average levels of irisin post-exercise were 72.82±42.96 ng/mL at CTLG, 282.50±75.96 ng/mL at AEEG, 488.14±61.30 ng/mL at ATEG, and p = 0.000. Average levels of IL-6 post-exercise were 51.09±15.68 pg/mL at CTLG, 58.94±3.62 pg/mL at AEEG, 129.29±52.65 pg/mL at ATEG, and p = 0.000. Average ∆ FAT were -0.02±0.34 % at CTLG, -0.35±0.19 % at AEEG, -0.46±0.18 pg/mL at ATEG, and p = 0.002. Both intervention of exercise consistently increased irisin levels, while IL-6 levels were found to increase only with aerobic treadmill exercise. Likewise, body fat only decreased after one session of treadmill aerobic exercise compared to ergo cycle aerobic exercise. Keywords: Aerobic exercise, interleukin 6, irisin, obesity, metabolism

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Section: Discussionmentioning

confidence: 99%

Treadmill has a more beneficial effect than cycling on fat loss through myokines secretion in obese women

Setiawan,

Rejeki,

Pranoto

et al. 2024

Retos

View full text Add to dashboard Cite

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Combined Aerobic Exercise with Intermittent Fasting Is Effective for Reducing mTOR and Bcl-2 Levels in Obese Females

Rejeki,

Pranoto,

Widiatmaja

et al. 2024

Sports

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The integration of combined aerobic exercise and intermittent fasting (IF) has emerged as a strategy for the prevention and management of obesity, including its associated health issues such as age-related metabolic diseases. This study aimed to examine the potential of combined aerobic exercise and IF as a preventative strategy against cellular senescence by targeting mTOR and Bcl-2 levels in obese females. A total of 30 obese women, aged 23.56 ± 1.83 years, body fat percentage (FAT) 45.21 ± 3.73% (very high category), BMI 30.09 ± 3.74 kg/m2 were recruited and participated in three different types of interventions: intermittent fasting (IF), exercise (EXG), and a combination of intermittent fasting and exercise (IFEXG). The intervention program was carried out 5x/week for 2 weeks. We examined mTOR and Bcl-2 levels using ELISA kits. Statistical analysis used the one-way ANOVA test and continued with Tukey’s HSD post hoc test, with a significance level of 5%. The study results showed that a combination of aerobic exercise and IF significantly decreased mTOR levels (−1.26 ± 0.79 ng/mL) compared to the control group (−0.08 ± 1.33 ng/mL; p ≤ 0.05). However, combined aerobic exercise and IF did not affect Bcl-2 levels significantly (−0.07 ± 0.09 ng/mL) compared to the control group (0.01 ± 0.17 ng/mL, p ≥ 0.05). The IF-only group, exercise-only group, and combined group all showed a significant decrease in body weight and fat mass compared to the control group (p ≤ 0.05). However, the combined aerobic exercise and IF program had a significant effect in reducing the total percentage of body fat and fat mass compared to the IF-only group (p ≤ 0.05). Therefore, it was concluded that the combined intermittent fasting and exercise group (IFEXG) undertook the most effective intervention of the three in terms of preventing cellular senescence, as demonstrated by decreases in the mTOR level, body weight, and fat mass. However, the IFEXG did not present reduced Bcl-2 levels.

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Impact of Time-Resricted Feeding and Aerobic Exercise Combination on Promotes Myokine Levels and Improve Body Composition in Obese Women

Cited by 2 publications

References 59 publications

Treadmill has a more beneficial effect than cycling on fat loss through myokines secretion in obese women

Treadmill has a more beneficial effect than cycling on fat loss through myokines secretion in obese women

Combined Aerobic Exercise with Intermittent Fasting Is Effective for Reducing mTOR and Bcl-2 Levels in Obese Females

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