Impact of Time to Anti-Vascular Endothelial Growth Factor Intervention on Visual Outcomes for Patients Diagnosed With Retinal Vein Occlusion

Hsueh, Jessica; Wai, Karen M.; Conti, Felipe F.; Conti, Thais F.; Singh, Rishi P.

doi:10.3928/23258160-20181101-03

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…However, in our study we did not find the baseline CRT and duration were associated with BCVA outcomes, which was not consistent with the former study. 28 We found higher baseline CRT was associated with a greater decrease in CRT that was consistent with the findings of Scott et al, 29 and we did not find duration was associated with the change of CRT.…”

Section: Discussionsupporting

confidence: 91%

Effect of Conbercept Treatment on Macular Edema and Microvascular Structure in Eyes with Retinal Vein Occlusions

Ding¹,

Wang²,

Bo³

et al. 2022

IJGM

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Objective To evaluate the efficacy on best corrected visual acuity (BCVA) and microvascular structure changes of conbercept intravitreal injection for the treatment of macular edema (ME) secondary to different types of retinal vein occlusion (RVO) and to explore the baseline OCTA parameters which were related to the change of BCVA and CRT after the intravitreal conbercept injection to RVO. Methods A retrospective observational study was conducted involving 67 eyes from 67 patients who were diagnosed with ME secondary to RVO between April 2019 to December 2020. The subjects were divided into branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) according to the involved vessel, subsequently the subjects received intravitreal conbercept treatment. The BCVA and fundus microstructure were measured to identify predictors of effective outcomes. Results BCVA, central retinal thickness (CRT), fovea avascular zone (FAZ), and foveal vascular density (FVD) in superficial capillary plexus (SCP) were significantly changed from baseline to 6-month follow-up in both CRVO and BRVO. In the BRVO group, age and baseline BCVA were correlated with changes of BCVA, while the baseline CRT, FVD in the DCP, and parafovea vascular density (PFVD) in DCP were associated with changes of CRT ( P <0.05). In the CRVO group, the baseline BCVA was correlated with changes of BCVA, while age, gender, baseline CRT, FVD in DCP, and PFVD in DCP were associated with changes of CRT ( P <0.05). There were no serious adverse events (SAEs) related to the drug or the injection procedure. Conclusion Intravitreal injections of conbercept can improve BCVA and CRT and change the FVD in SCP effectively both in BRVO and CRVO groups. In addition, the baseline FVD and PFVD in the DCP were related to the change of CRT after intravitreal conbercept treatment.

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Section: Discussionsupporting

confidence: 91%

Effect of Conbercept Treatment on Macular Edema and Microvascular Structure in Eyes with Retinal Vein Occlusions

Ding¹,

Wang²,

Bo³

et al. 2022

IJGM

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“…Specifically, glucocorticoid is convenient but inevitably produces various adverse side effects, such as increased susceptibility to infection, damage to the optic nerve, cataracts, and so on [5–7]. Although adverse events following anti-VEGF therapy are rare, it would be relevant to address these challenges, including frequent visits for injections [8], recurrent macular oedema [9, 10], anti-VEGF non-responders [9], time-dependent effects [11] and high expenses related to the agents [12]. Conventional medicine could not produce satisfactory results because of the blood-retina barrier and the unique structure of the retina.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression

Long

Yan

et al. 2019

BMC Ophthalmol

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Background Oxidative stress (OS) is an essential factor in the pathogenesis of branch retinal vein occlusion (BRVO). Studies have demonstrated the role of hydrogen gas in the regulation of OS. This study was designed to evaluate the efficacy of hydrogen gas on the BRVO rat model. Methods Twenty-four BRVO rats were randomly divided into two groups: the hydrogen gas (H) group (42% H 2 , 21% O 2 , 37% N 2 ) and the model (M) group (21% O 2 , 79% N 2 ). Rats in the H group inhaled hydrogen gas for 8 h every day up to 30 d post-occlusion. Twelve age-matched healthy rats served as the control (C) group. Retinal function and morphology were detected at 1, 7, 14 and 30 d post-occlusion. Furthermore, the expression of vascular endothelial growth factor (VEGF-α) was detected by immunofluorescent staining. Results Full-field electroretinography (ffERG) revealed that the amplitude of the b-wave (dark-adaptation 3.0 response), the amplitude of the OPs2 wave and the light-adapted flicker response in the H group were all higher than those in the M group at 7 d post-occlusion (all p < 0.05). The reopen time of occlusive retinal vessels in the H group was 2.235 ± 1.128 d, which was shorter than that in the M group (4.234 ± 2.236 d, p < 0.05). The rats in the H group had a thinner IPL + GCL + NFL and an increased total retina compared with those in the M group at 3 d post-occlusion ( p < 0.05), while the rats in the H group had a thicker INL, IPL + GCL + NFL and total retina compared with those at 7, 14 and 30 d post-occlusion ( p < 0.05). Moreover, the flow velocity of ear vein blood was increased in the H group compared with that in the M group ( p < 0.05). The expression of VEGF-α in the H group was dramatically decreased compared with that in the M group at 1, 7 and 14 d post-occlusion ( p < 0.05), while the expression kept in similar level at 30 d post-occlusion ( p > 0.05 ). Conclusions Our findings demonstrate that inhalation of hydrogen gas could alleviate retinal oedema, shorten reopen time and improve retinal function, and the potential mechanism might be related to a decrease in VEGF-α expression.

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Long-term outcomes of anti-VEGF therapy for macular edema in retinal vein occlusion

Дроздова¹

2022

Vestn. oftal'mol.

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Impact of Time to Anti-Vascular Endothelial Growth Factor Intervention on Visual Outcomes for Patients Diagnosed With Retinal Vein Occlusion

Cited by 3 publications

References 14 publications

Effect of Conbercept Treatment on Macular Edema and Microvascular Structure in Eyes with Retinal Vein Occlusions

Effect of Conbercept Treatment on Macular Edema and Microvascular Structure in Eyes with Retinal Vein Occlusions

Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression

Long-term outcomes of anti-VEGF therapy for macular edema in retinal vein occlusion

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