Impact of toothpaste on oral health-related quality of life in people with dentine hypersensitivity

Abstract

BackgroundDentine hypersensitivity can impact functional status and everyday activities such as eating and talking. This study aimed to assess changes in oral health-related quality of life measures in individuals with dentine hypersensitivity following long-term use (24 weeks) of a commercially available toothpaste marketed for dentine hypersensitivity relief.MethodsThis study was conducted across two sites and enrolled 75 adults with ≥2 non-adjacent sensitive teeth. Participants were assigned to twice-daily brushing with toothpaste containing 0.454% w/w stannous fluoride (1100 ppm fluoride). Every 4 weeks, participant-reported outcomes were assessed using the Dentine Hypersensitivity Experience Questionnaire (DHEQ), a condition specific oral health-related quality of life scale that has five domains and includes questions on social and emotional impact, restrictions, adaptations and effect on life overall. Responses to a clinically applied evaporative (air) stimulus were assessed using the examiner-observed Schiff sensitivity scale and Labelled Magnitude Scales (LMS), which included dentine hypersensitivity-specific descriptors of intensity, duration, tolerability and descriptive qualities of the participant’s response.ResultsParticipant-reported outcomes demonstrated reduction of the impact of dentine hypersensitivity over time on health-related quality of life, as measured by the DHEQ. This reached statistical significance from Week 8 onwards (p < 0.0001 versus baseline) for the Total DHEQ score, with scores continually decreasing at each timepoint. Most domain scores followed a similar pattern. Statistically significant reductions were also detected for the examiner-observed Schiff Sensitivity Scale scores at all timepoints (including at 4 weeks) (p < 0.05), which were mirrored by LMS responses. The toothpaste was generally well-tolerated.ConclusionsThese results show that long-term use of a sensitivity toothpaste containing 0.454% w/w stannous fluoride has a beneficial, ongoing, impact on the oral health-related quality of life of people with dentine hypersensitivity.Trial registrationThis study was registered at Clinicaltrials.gov (https://clinicaltrials.gov/ct2/show/NCT02752958) on April 27, 2016.

Bioactive glass and arginine dentifrices reduce root sensitivity during daily activities following non‐surgical periodontal therapy: A randomized controlled trial

“…A long‐term study on the impact of DH and oral health‐related QoL demonstrated that using a dentifrice containing 0.454% w/w stannous fluoride required 8 weeks to show a reduction of the impact of DH on health‐related QoL 48 . Our study found that using CSPS and arginine dentifrices reduced the RS intensity caused by cold food and toothbrushing within 2–4 weeks.…”

The synthesis of Tween80/calcium phosphate nanocomposite bioactive gelatine-based gels as a proof of concept for tooth sensitivity home-treatment

“…The effectiveness of dentine tubule occlusion depends on the size and shape of the constituent calcium phosphate particles. Spherical particles smaller than or comparable to the dentine tubule (approximately 1-2 µm) can infiltrate the tubules without disturbing other parts of the teeth 25,26) . When the size and morphology of the calcium phosphate nanoparticles embedded in the gel were studied using TEM, the size of the embedded nanoparticles was found to decrease from approximately 400 nm to 300 nm compared with the emulsion without gelatine.…”

Clinical efficacy of hydroxyapatite toothpaste containing Polyol Germanium Complex (PGC) with threonine in the treatment of dentine hypersensitivity

“…The oral hygiene level was evaluated through the Turesky modification of the Quigley-Hein Plaque Index (TQHPI) ( Mason et al, 2019 ). All vestibular and oral surfaces of the teeth were stained with a plaque staining solution (CURAPROX PCA 260).…”

“…Albeit that DH is a chronic condition that can worsen over time and requires qualified treatment ( Zeola et al, 2019 ), patients often adapt to the inconveniences and do not seek medical help from dentists ( Mason et al, 2019 ).…”