Impact of Tracheal Mucosa Involvement on Clinical Characteristics of Sarcoidosis

Ding, Xuanfeng; Qin-Zhi, Xu; Duan, Yun-you; Zhang, Chunyan; Chao-Sheng, Pen; Ning, Hao-yong; Li, Yongqun; Meng, Jiguang; Zhou-Shan, Nie; Feng, Hao

doi:10.1097/smj.0b013e318213ec03

Cited by 9 publications

(4 citation statements)

References 10 publications

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“…This study compared respiratory symptoms in 87 patients who had undergone tracheal biopsy and found that significantly more (92%) of those who had granulomatous tracheitis complained of cough compared with those (49%) who had normal tracheal biopsies [6]. This study did not report on the bronchoscopic appearances of the bronchial mucosa nor on the histological appearances of bronchial biopsies but it seems plausible that cough in the latter group may have been caused by inflammation of the bronchi or smaller airways without tracheal involvement.…”

Section: Sarcoidosismentioning

confidence: 99%

Cough, sarcoidosis and idiopathic pulmonary fibrosis: raw nerves and bad vibrations

Harrison

2013

Cough

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Cough is a common symptom in people who develop interstitial lung diseases (ILD). The pathological features of the ILDs are many and varied suggesting that the cause of cough may also vary with each disease. This article reviews what is currently known about cough in sarcoidosis and idiopathic pulmonary fibrosis; two of the commonest ILDs. It also outlines some of the theories which have been proposed to explain why cough develops in these conditions and describes what little is known about how to treat it.

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Section: Sarcoidosismentioning

confidence: 99%

Cough, sarcoidosis and idiopathic pulmonary fibrosis: raw nerves and bad vibrations

Harrison

2013

Cough

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“…Few have investigated the mechanisms of cough in sarcoidosis to date. Postulated mechanisms include airway inflammation or hyper-responsiveness, interstitial distortion, vagus nerve disruption, laryngeal and vocal cord involvement, granulomatous infiltration of the pulmonary vasculature, and heightened CRS ( 63 , 142 ).…”

Section: Sarcoidosismentioning

confidence: 99%

“…In a retrospective study of tracheal biopsy in sarcoidosis, Ding et al . reported more self-reported cough in patients with tracheitis compared to those without (92% vs. 49% respectively) ( 63 ). Taken together, endobronchial sarcoidosis and airway neutrophilic inflammation are associated with cough though the precise mechanism remains unexplored.…”

Section: Sarcoidosismentioning

confidence: 99%

Cough in chronic lung disease: a state of the art review

Hirons,

Rhatigan,

Kesavan

et al. 2023

J Thorac Dis

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Chronic cough (CC; ≥8 weeks in duration) is a common and burdensome feature of respiratory diseases. The understanding of cough has progressed significantly in recent years, albeit largely in refractory (unexplained) chronic cough (RCC) in the absence of other respiratory conditions. The prevalence of CC in respiratory diseases is poorly described, but estimates have been reported: asthma (8–58%), chronic obstructive pulmonary disease (COPD; 10–74%), bronchiectasis (82–98%), interstitial lung disease (ILD; 50–89%) and sarcoidosis (3–64%). CC in respiratory conditions generally predicts impaired health status and more severe disease. It is associated with increased symptom burden and disease severity in asthma, COPD, bronchiectasis and ILD, higher exacerbation frequency in asthma and bronchiectasis, and increased mortality and lung transplantation in idiopathic pulmonary fibrosis (IPF). Physiologically, heightened cough reflex sensitivity (CRS) has been reported and postulated to be mechanistic in isolated RCC. Cough reflex hypersensitivity (CRH) has also been reported in asthma, COPD, bronchiectasis, ILD and sarcoidosis. Unlike recent advances in isolated RCC, there are limited studies and understanding of central cough neuropathways in other respiratory conditions. Of note, dysfunctional central voluntary cough suppression neuropathways and physiology were observed in isolation in RCC; cough suppression is preserved in COPD. Understanding in the mechanism of RCC cannot be simply extrapolated to other respiratory conditions. The restricted understanding of cough mechanisms in these conditions has limited cough-specific therapeutic options in this context. There is currently an unmet need to expand our understanding of cough in chronic respiratory conditions, both in order to improve the quality of life of patients, and to improve knowledge of cough in general. This review aims to describe the prevalence, impact, pathophysiology and management of CC in asthma, COPD, bronchiectasis, ILD and sarcoidosis.

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“…Probably the most common mechanisms causing pulmonary sarcoidosis-associated cough are airway irritation and mechanical airway damage caused directly by granulomatous inflammation. Sarcoid granulomas have a predilection for depositing in the airways [ 20 ] and the presence of endobronchial sarcoidosis lesions has been associated with cough [ 21 , 22 ]. This airway irritation/mechanical damage may cause an asthma-like syndrome [ 23 ] in which afferent nerve fibers are stimulated, thereby inducing cough [ 15 , 24 ].…”

Section: Coughmentioning

confidence: 99%

The Symptoms of Pulmonary Sarcoidosis

Judson

2023

JCM

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The aim of this manuscript is to provide a comprehensive review of the etiology, measurement, and treatment of common pulmonary symptoms associated with sarcoidosis. The assessment of symptoms associated with pulmonary sarcoidosis is an important component of disease management. Some symptoms of pulmonary sarcoidosis are sensitive but nonspecific markers of disease activity, and the absence of such symptoms provides evidence that the disease is quiescent. Although quantifiable objective measurements of pulmonary physiology and chest imaging are important in the assessment of pulmonary sarcoidosis, they correlate poorly with the patient’s quality of life. Because the symptoms of pulmonary sarcoidosis directly relate to how the patient feels, they are reasonable endpoints in terms of clinical research and individual patient care. Recently, the symptoms of pulmonary sarcoidosis are capable of being quantified via patient-reported outcome measures and electronic devices. We conclude that a thorough assessment of the symptoms associated with pulmonary sarcoidosis improves patient care because it is a useful screen for manifestations of the disease, provides insight into the pathophysiology of manifestations of sarcoidosis, and may assist in optimizing treatment.

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Impact of Tracheal Mucosa Involvement on Clinical Characteristics of Sarcoidosis

Abstract: Sarcoidosis with tracheal mucosa involvement that can lead to cough and other respiratory symptoms, may be a manifestation of sarcoidosis activity, and usually requires drug treatment (including corticosteroid treatment).

Cited by 9 publications

References 10 publications

Cough, sarcoidosis and idiopathic pulmonary fibrosis: raw nerves and bad vibrations

Cough, sarcoidosis and idiopathic pulmonary fibrosis: raw nerves and bad vibrations

Cough in chronic lung disease: a state of the art review

The Symptoms of Pulmonary Sarcoidosis

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