Impact of traditional medicinal plant extracts on antiretroviral drug absorption

Brown, L. D.; Heyneke, O.; Brown, Deon; Wyk, J.P.H. van; Hamman, Josias H.

doi:10.1016/j.jep.2008.06.028

Cited by 55 publications

(42 citation statements)

References 16 publications

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“…Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity. Yet Brown et al (2008) found that Hypoxis hemerocallidea and l-canavanine interact with the efflux of nevirapine across intestinal epithelial cells and therefore can potentially increase the bioavailability of this antiretroviral drug when taken concomitantly. Thus far, biomedical evidence has revealed that African potato extracts possess anti-inflammatory, antineoplastic, antioxidant, antidiabetic and antiinfective properties in vivo and in vitro.…”

Section: Discussionmentioning

confidence: 99%

Antiretrovirals and the use of traditional, complementary and alternative medicine by HIV patients in KwaZulu-Natal, South Africa: a longitudinal study

Peltzer

Preez²,

Ramlagan³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

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The aim of this prospective study (20 months) was to assess HIV patients' use of Traditional, Complementary and Alternative Medicine (TCAM) and its effect on ARV adherence at three public hospitals in KwaZulu-Natal, South Africa. Seven hundred and thirty-five (29.8% male and 70.2% female) patients who consecutively attended three HIV clinics completed assessments prior to ARV initiation, 519 after 6 months, 557 after 12 and 499 after 20 months on antiretroviral therapy (ART). Results indicate that following initiation of ARV therapy the use of herbal therapies for HIV declined significantly from 36.6% prior to ARV therapy to 8.0% after 6 months, 4.1% after 12 months and 0.6% after 20 months on ARVs. Faith healing methods (including spiritual practices and prayer) declined from 35.8% to 22.1%, 20.8% and 15.5%, respectively. In contrast, the use of micronutrients (vitamins, etc.) significantly increased from 42.6% to 78.2%. The major herbal remedies that were used prior to ART were unnamed traditional medicine, followed by imbiza (Scilla natalensis planch), canova (immune booster), izifozonke (essential vitamins mixed with herbs), African potato (Hypoxis hemerocallidea), stametta (aloe mixed with vitamins and herbs) and ingwe (tonic). Herbal remedies were mainly used for pain relief, as immune booster and for stopping diarrhea. As herbal treatment for HIV was associated with reduced ARV adherence, patient's use of TCAM should be considered in ARV adherence management.

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Section: Discussionmentioning

confidence: 99%

Antiretrovirals and the use of traditional, complementary and alternative medicine by HIV patients in KwaZulu-Natal, South Africa: a longitudinal study

Peltzer

Preez²,

Ramlagan³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

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“…A recent study by Brown et al evaluating the effect of water extracts of two traditional African medicinal plants, H. hemerocallidea (also known as African potato) and S. frutescens (also known as cancer bush), as well as l -canavanine (a constituent of S. frutescens ) on the transport of nevirapine across human intestinal epithelial cells has found that H. hemerocallidea and l -canavanine interact with the effl ux of nevirapine across intestinal epithelial cells, while the effect of S. frutescens on nevirapine transport was not statistically signifi cantly different from the control [17] . These fi ndings suggest that H. hemerocallidea and l -canavanine can potentially increase the bioavailability of nevirapine when taken concomitantly [17] .…”

Section: Considerations For Drug -Herb Interactions For Arv Agentsmentioning

confidence: 99%

Drug–Herb Interactions in Patients with HIV/AIDS

Rakhmanina

Anker

2010

Herbal Supplements

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“…It is traditionally used as a tea (aqueous extract) to remedy a variety of ailments ranging from cancer and diabetes to intestinal disease (Chinkwo, 2005;van Wyk and Gericke, 2000), and recently to improve the overall health of human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) patients (Klos et al, 2009;Brown et al, 2008;Harnett et al, 2005;Grandi et al, 2005;Morris, 2001). S. frutescens has been commercially cultivated on small scale since 1990 (van Wyk and Albrecht, 2008).…”

Section: Introductionmentioning

confidence: 99%

Differential signaling involved in Sutherlandia frutescens-induced cell death in MCF-7 and MCF-12A cells

Vorster¹,

Stander²,

Joubert³

2012

Journal of Ethnopharmacology

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Ethnopharmacological relevance: The scientific study of natural products traditionally used in anticancer preparations has yielded several therapeutically relevant compounds. One of these traditional preparations with potentially beneficial properties is aqueous extracts of Sutherlandia frutescens, a shrub indigenous to the Western Cape region of South Africa. Classification:Malignant disease and immunosuppression

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Impact of traditional medicinal plant extracts on antiretroviral drug absorption

Cited by 55 publications

References 16 publications

Antiretrovirals and the use of traditional, complementary and alternative medicine by HIV patients in KwaZulu-Natal, South Africa: a longitudinal study

Antiretrovirals and the use of traditional, complementary and alternative medicine by HIV patients in KwaZulu-Natal, South Africa: a longitudinal study

Drug–Herb Interactions in Patients with HIV/AIDS

Differential signaling involved in Sutherlandia frutescens-induced cell death in MCF-7 and MCF-12A cells

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