Impact of transcranial direct current stimulation on somatosensory transfer learning: When the secondary somatosensory cortex comes into play

Hirtz, Raphael; Weiß, Thomas; Huonker, Ralph; Witte, Otto W.

doi:10.1016/j.brainres.2018.03.031

Cited by 1 publication

(8 citation statements)

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“…Overall, an improvement in tactile perception, characterized by a decrease in discrimination thresholds, after tDCS in the experimental as compared to the control group, was observed in six of the nine studies (Fujimoto et al, 2014;Godde et al, 2020;Saito et al, 2019;Swissa et al, 2022;Ragert et al, 2008;Yau et al, 2014). Conversely, three studies reported that tDCS did not affect tactile discrimination perception compared to the control group (Fujimoto et al, 2017;Hilgenstock et al, 2016;Hirtz et al, 2018).…”

Section: Effects Of Tdcs On Tactile Discriminationmentioning

confidence: 86%

“…Figure 5A). For risk of detection bias, the subgroup of 5 studies (Fujimoto et al, 2014(Fujimoto et al, , 2017Hilgenstock et al, 2016;Swissa et al, 2022;Ragert et al, 2008) with a low risk revealed a significant effect (Z = 3.19; SMD = −4.77; 95 % CI, − 7.71 to -1.84; P = 0.001; n = 69) while the effect in the high-risk subgroup with four studies (Godde et al, 2020;Hirtz et al, 2018;Saito et al, 2019;Yau et al, 2014) was not significant (Z = 2.62; SMD = −3.61; 95 % CI, − 6.31 to 0.90; P = 0.009; n = 90; for detailed statistics, cf. Figure 5B).…”

Section: Subgroup Analysis: Risk Biasesmentioning

confidence: 98%

“…In eight studies (Fujimoto et al, 2014(Fujimoto et al, , 2017Godde et al, 2020;Hilgenstock et al, 2016;Hirtz et al, 2018;Ragert et al, 2008;Saito et al, 2019;Yau et al, 2014), tactile spatial discrimination was measured with the grating orientation discrimination task (GOT). The GOT is an established measure to assess tactile spatial discrimination.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…A high risk of selection bias (random sequence generation) was assessed for two studies (Yau et al, 2014;Saito et al, 2019) because no randomization method was mentioned, which may cause the groups to differ systematically. High risk for detection bias was determined for four studies (Godde et al, 2020;Hirtz et al, 2018;Saito et al, 2019;Yau et al, 2014) as they were only single-blinded trials. Correspondingly, these studies also had an unclear 'risk of bias' for allocation concealment.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…Figure 5B). Finally, for risk of attrition bias, after excluding the subgroup of two studies with unclear attrition bias ( Fujimoto et al, 2017;Hilgenstock et al, 2016), the effect for the remaining subgroup with low risk (Fujimoto et al, 2014;Godde et al, 2020;Hirtz et al, 2018;Ragert et al, 2008;Saito et al, 2019;Swissa et al, 2022;Yau et al, 2014) remained significant (scenario 1: Z = 4.36; SMD = −4.75; 95 % CI, − 6.88 to -2.61; P<0.0001; scenario 2: Z = 4.15; SMD = −4.81; 95 % CI, − 7.09 to -2.54; P<0.0001; n = 124; for detailed statistics, cf. Figure 5C).…”

Section: Subgroup Analysis: Risk Biasesmentioning

confidence: 99%

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Does Transcranial Direct Current Stimulation Improve Tactile spatial discrimination? A Systematic Review and Meta-Analysis

Khalil¹,

Daniels²,

Karim³

et al. 2023

Preprint

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Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique for modulating neural processes, enabling the direct investigation of how experimentally altered neural activity affects behavior. It has been suggested that using tDCS for targeted enhancement or attenuation of the excitability of the somatosensory cortex alters tactile perception; however, studies published so far have revealed contradictory findings. Objectives: Systematically determine the influence of tDCS on tactile perception in healthy adults. Methods: We performed a comprehensive literature search on PubMed and filtered the results following the Preferred Report Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Selection Criteria: To achieve a homogenous sample, we selected only studies that used tDCS for measuring tactile spatial discrimination, as revealed by two widely used standardized tests, the grating orientation task, and the 2-point orientation discrimination task. Data Collection and Analysis: Nine studies could be identified for which effect sizes and confidence intervals were either reported or could be calculated based on the statistics provided. Main Results: Our meta-analysis indicates a significant but small benefit from tDCS for tactile spatial discrimination in the experimental vs. control groups; however, there was a high level of heterogeneity. Remarkably, our subanalysis based on the target sites (primary somatosensory cortex or motor cortex) and duration of tDCS stimulation (i.e., >20 minutes) revealed a significant effect on tactile spatial discrimination. Conclusion: Because of the variability in the methodological protocols and the partly small sample sizes of the included studies, more empirical high-quality randomized controlled trials are required to verify these intervention effects further.

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