Impact of transcranial direct current stimulation combined with motor-cognitive intervention on post-stroke cognitive impairment

Zhang, Liya; Zhou, Liang; Ye, Qing; Zhang, Li; Kong, Yurou; Xia, Siying

doi:10.1007/s10072-023-07156-2

Cited by 3 publications

References 27 publications

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Investigate the therapeutic differences between Temporal Interference Stimulation and Transcranial Alternating Current Stimulation on Post-stroke cognitive dysfunction: A Protocol for Clinical Trial

MAIMAITIAILI,

Shi,

et al. 2024

Preprint

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Introduction Transcranial alternating current stimulation (tACS) and temporal interference stimulation (TIS) as electrical neuromodulation therapy, have shown promising applications in cognitive impairments. Meanwhile TIS technique is more novel with deep and non-invasive brain stimulation . At present, the therapeutic or neuromodulation differences between TIS with tACS on Post-stroke cognitive dysfunction(PSCI) is still unclear. Here, we aim to compare and analysis the neuromodulation model and clinical performances of TIS and tACS. Methods and analysis The prospective, single-blind and randomized controlled trial will be conducted over a two-week period. Through precise statistical sample size calculation,thirty-six eligible participants with mild PSCI will be recruited and randomly allocated to either the tACS or the TIS group. Participants in the TIS group will receive stimulation at frequencies of 2005Hz and 2010Hz with hippocampus target(in the hippocampal region). Those in the tACS group will undergo 5Hz stimulation of the dorsolateral prefrontal cortex (DLPFC). The intervention will last for two weeks, with each participants receiving 25-minute stimulation sessions once a day, five times per week. The primary outcome measure will be the Montreal cognitive assessment (MoCA), while secondary outcomes will include performance on the N-back task, digital span test (DST), shape trails test (STT) and functional near-infrared spectroscopy (fNIRS). All clinical assessments will be collected at two time points: pre-intervention (T1) and post-intervention (T2). Trial registration The trial protocol is registered with www.chictr.org.cn under protocol registration number ChiCTR2400081207.Registered February 26, 2024.

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Investigate the therapeutic differences between Temporal Interference Stimulation and Transcranial Alternating Current Stimulation on Post-stroke cognitive dysfunction: A Protocol for Clinical Trial

MAIMAITIAILI,

Shi,

et al. 2024

Preprint

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Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysis

Zhao,

Meng,

et al. 2024

Front. Neurol.

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BackgroundPrevious studies have suggested that repetitive transcranial magnetic stimulation (rTMS) may be an effective and safe alternative treatment for post-stroke cognitive impairment (PSCI). Similarly, the application of transcranial direct current stimulation (tDCS) during stroke rehabilitation has been shown to improve cognitive function in PSCI patients. However, there have been conflicting results from some studies. Therefore, this study aims to conduct a meta-analysis to evaluate the effects of tDCS and rTMS on PSCI.MethodsThe meta-analysis search for articles published from the initial availability date to 5 February 2024 in databases. The extracted study data were entered into STATA 12.0 software for statistical analysis.ResultsThis meta-analysis provides evidence that both rTMS and tDCS have a positive impact on general cognitive function in PSCI patients [immediate effect of rTMS: standard mean difference (SMD) = 2.58, 95% confidence interval (CI) = 1.44 to 3.71; long-term effect of rTMS: SMD = 2.33, 95% CI = 0.87–3.78; immediate effect of tDCS: SMD = 2.22, 95% CI = 1.31–3.12]. Specifically, rTMS was found to significantly improve attention, language, memory, and visuospatial functions, while it did not show a significant therapeutic effect on executive function (attention: SMD = 3.77, 95% CI = 2.30–5.24; executive function: SMD = −0.52, 95% CI = −3.17–2.12; language: SMD = 3.43, 95% CI = 1.50–5.36; memory: SMD = 3.52, 95% CI = 1.74–5.30; visuospatial function: SMD = 4.71, 95% CI = 2.61–6.80). On the other hand, tDCS was found to significantly improve executive and visuospatial functions but did not show a significant improvement in attention function and memory (attention: SMD = 0.63, 95% CI = −0.30–1.55; executive function: SMD = 2.15, 95% CI = 0.87–3.43; memory: SMD = 0.99, 95% CI = −0.81–2.80; visuospatial function: SMD = 2.64, 95% CI = 1.04–4.23).ConclusionIn conclusion, this meta-analysis demonstrates that both rTMS and tDCS are effective therapeutic techniques for improving cognitive function in PSCI. However, more large-scale studies are needed to further investigate the effects of these techniques on different cognitive domains in PSCI.

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Knowledge, Attitude, and Practices Among Clinical Physiotherapists Regarding Transcranial Direct Current Stimulation Application in Stroke Rehabilitation: Questionnaire Development and Validation via Multicenter Observations in Saudi Arabia

Alshehri,

Esht,

Alajam

et al. 2024

Journal of Disability Research

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Transcranial direct current stimulation (tDCS) is known to modulate the brain excitability and enhance cognitive functions and neuroplasticity, although adherence to its administration in post-stroke rehabilitation is still being understudied. This study set out to develop and content validate a questionnaire to assess clinical physiotherapists’ knowledge, attitude, and practices regarding the use of tDCS following a stroke. In order to gather expert opinion and come to a consensus on a certain topic, the Delphi technique was employed. The measure was validated using both qualitative (cognitive interviewing) and quantitative (content validity) methods on a panel of 32 experts. Calculations were made for the content validity ratio (CVR), content validity index (CVI), item-level CVI (I-CVI), and scale-level CVI universal agreement (S-CVI/UA). A total of 48 interdisciplinary experts in the field of neurosciences were invited. In all, 32 specialists from Neurology, General Medicine, Neurophysiotherapy, and Physiology departments accepted the invitation and provided their opinion for instrument analysis. After two rounds, early iterations of this instrument demonstrated an acceptable CVR value of 1, high overall content validity (S-CVI/UA = 0.86), and high content validity of individual items (I-CVI range: 0.83-1.00). The kappa value varied between 0.75 and 1, which is excellent. Its content is therefore deemed validated. Through an iterative process, its development and assessment revealed strong item-content validity for determining the domains of the questionnaire. It is anticipated that this metric could be utilized to increase the adherence rate of post-stroke tDCS application in Saudi Arabia.

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Impact of transcranial direct current stimulation combined with motor-cognitive intervention on post-stroke cognitive impairment

Cited by 3 publications

References 27 publications

Investigate the therapeutic differences between Temporal Interference Stimulation and Transcranial Alternating Current Stimulation on Post-stroke cognitive dysfunction: A Protocol for Clinical Trial

Investigate the therapeutic differences between Temporal Interference Stimulation and Transcranial Alternating Current Stimulation on Post-stroke cognitive dysfunction: A Protocol for Clinical Trial

Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysis

Knowledge, Attitude, and Practices Among Clinical Physiotherapists Regarding Transcranial Direct Current Stimulation Application in Stroke Rehabilitation: Questionnaire Development and Validation via Multicenter Observations in Saudi Arabia

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