Impact of Transitory Hyperprolactinemia on Clinical Outcome of In Vitro Fertilization and Embryo Transfer

Zhong, Yiping; Shen, Xiaoting; Ying, Ying; Wu, Hai‐Tao; Qi, Quan; Zhou, Canquan; Zhuang, Guang-lun

doi:10.2478/v10011-011-0039-x

Cited by 6 publications

(16 citation statements)

References 14 publications

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“…This seems to be the case in the current study, as LH was not elevated, and similar LH concentrations were observed in both groups. P elevation varies widely among reports (e.g., 0.8 ng/ml and 9.54 nmol/l) [ 8 , 27 ]. In our study, a P level ≥1.3 ng/ml was set as the threshold to define PPE, and the incidence of PPE was found to be 32.6%, which is consistent with the 38.3% reported by Bosch et al and 36.7% reported by Li et al [ 8 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Premature Progesterone Elevation Does Not Affect Pregnancy Outcome in High-Responder Patients Undergoing Short-Interval Coasting in IVF Cycles

Acet

Aktün

Başaranoğlu

et al. 2015

Med Sci Monit Basic Res

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BackgroundWe aimed to present the relationship between premature progesterone elevation (PPE) and clinical outcomes in high-responder patients who had a coasting period of <4 days in length due to their high risk of developing ovarian hyperstimulation syndrome (OHSS) and who were treated with a long-acting gonadotropin-releasing hormone agonist (GnRH-agonist) protocol in in vitro fertilization-embryo transfer (IVF-ET) cycles.Material/MethodsThis retrospective study was conducted at the University Hospital Assisted Reproductive Technology Center. The outcomes of 101 patients undergoing IVF- intracytoplasmic sperm injection (ICSI) cycles who showed a high response to COH (estradiol >4000 pg/ml and/or >20 follicles each ≥10 mm in diameter and at least 20% ≥15 mm) and who were coasted for <4 days were evaluated. Number of oocytes, 2 pronuclei (PN) embryos, implantation rate, and live birth rate were measured.ResultsThe incidence of PPE was 32.6%. Compared with those without PPE, patients with PPE had a higher number of oocytes retrieved. Total mature and fertilized oocytes and the mean number of embryos transferred were not significantly different between groups. Live birth rates (41.9% vs. 38.7%) and implantation rates (26.5% vs. 23%) were also not significantly divergent in the PPE and non-PPE groups, respectively.ConclusionsP concentrations ≥1.3 ng/ml on the day of human chorionic gonadotropin (hCG) administration, designated in this study as PPE, does not appear to be related to adverse effects in terms of clinical outcomes in high-responder patients undergoing coasting <4 days due to their high risk of developing OHSS treated with a long-acting GnRH-a protocol in IVF-embryo transfer cycles.

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Section: Discussionmentioning

confidence: 99%

Premature Progesterone Elevation Does Not Affect Pregnancy Outcome in High-Responder Patients Undergoing Short-Interval Coasting in IVF Cycles

Acet

Aktün

Başaranoğlu

et al. 2015

Med Sci Monit Basic Res

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“…An increasing body of evidence supports the pleiotropic role of prolactin in reproduction, growth, metabolism, electrolyte transport, behaviour, immunity and carcinogenesis [ 1 ]. Regarding the physiological effects, aside from the traditional role on lactation, several studies have suggested a more complex role of prolactin in reproduction by its benefic effects on oocytes development [ 2 , 3 , 4 , 5 ], corpus luteum formation and survival [ 6 ], implantation [ 7 ], steroidogenesis [ 8 , 9 ] and immunomodulatory effects [ 10 , 11 ]. Thus, a certain level of circulating prolactin might be necessary for optimal reproductive outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…During the menstrual cycle, fluctuations of the prolactin level were noticed, supporting the involvement of prolactin in variate aspects of reproduction. During controlled ovarian stimulation (COS) for assisted reproductive technology a particular dynamic of serum prolactin level, characterized by transient hyperprolactinemia, was also reported [ 8 , 12 , 13 ] with incompletely known significance and impact on fertility treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes—A Review of the Literature

Iancu¹,

Albu

2023

Pharmaceuticals

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Hyperprolactinemia is a known cause of amenorrhea and infertility. However, there is an increasing body of evidence suggesting that prolactin is involved in multiple physiological aspects of normal reproduction. Thus, the present paper aims to review the current literature regarding the relationship between serum prolactin level and in vitro fertilization (IVF)/intracytoplasmic sperm injection outcome and the role of dopamine agonists treatment in IVF success. Moreover, the mechanisms by which prolactin may exert its role in fertility and infertility were summarized. Although not all studies agree, the available evidence suggests that higher prolactin levels in follicular fluid are associated with increased oocytes competence, but also with positive effects on corpus luteum formation and survival, endometrial receptivity, blastocyst implantation potential and survival of low-motile sperm. Transient hyperprolactinemia found in IVF cycles was reported in most of the studies not to be related to IVF outcome, although a few reports suggested that it may be associated with higher implantation and pregnancy rates, and better-cumulated pregnancy outcomes. Administration of dopamine agonists for hyperprolactinemia preceding IVF treatment does not seem to negatively impact the IVF results, while treatment of transient hyperprolactinemia during IVF might be beneficial in terms of fertilization rates and conception rates. Due to limited available evidence, future studies are necessary to clarify the optimal level of circulating prolactin in patients performing IVF and the role of dopamine agonist treatment.

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“…It may also interfere with the function of the corpus luteum resulting in luteal phase defects as well as irregular implantation and embryo growth. Speci ic studies have shown the presence of a state of Hyperprolactinemia during cycles of IVF / Intracytoplasmic Sperm Injection (ICSI) (Zhong et al, 2012;Boyers et al, 1987). In the early stages of pregnancy, hCG is luteotropic, preserving progesterone development and endometrial support.…”

Section: Introductionmentioning

confidence: 99%

Role Of Prolactin And B-Hcg In Female Infertility

Ambad

Butola

Dhok

et al. 2021

ijrps

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The World Health Organization (WHO) describes infertility as a disability for couples in childbirth to attain pregnancy within 12 months of daily sexual intercourse. The reproductive years of women starts when she starts her menstrual cycle during puberty and capacity to have a child typically ends about age (45) years. However, it may be possible for a woman to become pregnant before her cycles end with menopause. Infertility affects 13–20 per cent of couples worldwide, regardless of race or ethnicity. The present study aim was To study the levels of prolactin and beta hCG in female infertility. And To correlate the levels of prolactin and beta hCG in infertile womens and healthy controls. The present study was conducted in the departments of biochemistry and dept. of obstetrics and gynaecology. The study was conducted on two groups of 40 infertile Females and 40 healthy controls. Serum sample used for estimation of prolactin and hCG, assessed by dry chemistry analyzer. Serum prolactin levels in infertile females is 33.96±11.46 and hCG levels was 86.38±12.45, which was higher in infertile female as compared to healthy control with a p-value of<0.05. The present study concludes that Hyperprolactinemia is a major contributing hormonal factor in infertility among infertile women and, as such, prolactin and hCG should be measured in infertile women.

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Impact of Transitory Hyperprolactinemia on Clinical Outcome of In Vitro Fertilization and Embryo Transfer

Cited by 6 publications

References 14 publications

Premature Progesterone Elevation Does Not Affect Pregnancy Outcome in High-Responder Patients Undergoing Short-Interval Coasting in IVF Cycles

Premature Progesterone Elevation Does Not Affect Pregnancy Outcome in High-Responder Patients Undergoing Short-Interval Coasting in IVF Cycles

Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes—A Review of the Literature

Role Of Prolactin And B-Hcg In Female Infertility

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