Impact of triglyceride-rich lipoproteins on early in-stent neoatherosclerosis formation in patients undergoing statin treatment

Sakai, Rikuo; Sekimoto, Teruo; Koba, Shinji; Mori, Hiromu; Matsukawa, Naoki; Arai, Taito; Yokota, Yuya; Sato, Sadayuki; Tanaka, Hideaki; Masaki, Ryota; Oishi, Yosuke; Ogura, Kunihiro; Arai, Ken; Nomura, Kosuke; Sakai, Koshiro; Tsujita, Hiroaki; Kondo, Seita; Tsukamoto, Shigeto; Suzuki, Hiroshi; Shinke, Toshiro

doi:10.1016/j.jacl.2023.01.004

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…A recent OCT study of early ISR combined with NA also found that poor LDL-C control after percutaneous coronary intervention (PCI) was the main cause of early NA [ 10 ]. However, Sakai et al [ 12 ] reported that in patients receiving statin therapy after PCI, triacylglycerol-rich lipoprotein cholesterol and APOB were involved in early NA formation, but LDL-C was not. Therefore, whether LDL-C plays a role in NA formation in patients with late ISR remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Studies of in situ lesions have shown that intensive lipid-lowering therapy can stabilize and reverse plaques [ 7 , 8 ], but its role in NA formation remains controversial. Some studies have shown that elevated LDL-C levels facilitate NA formation [ 9 – 11 ], whereas others have shown that NA formation is not related to LDL-C levels [ 1 , 12 , 13 ]. More importantly, no systematic studies on the risk factors for late ISR with NA formation have been reported, and it remains unclear whether elevated LDL-C levels are also involved in the progression of late NA.…”

Section: Introductionmentioning

confidence: 99%

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Association of LDL-C level with neoatherosclerosis and plaque vulnerability in patients with late restenosis: an optical coherence tomography study

Liu,

Deng,

Zhao

et al. 2023

Int J Cardiovasc Imaging

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Neoatherosclerosis (NA) is a significant contributor to late stent failure; however, predictors of late in-stent restenosis (ISR) with NA have not been systematically reported. This study aimed to identify predictors of NA incidence and plaque vulnerability in patients with late ISR and the role of low-density lipoprotein cholesterol (LDL-C) levels in this process. A total of 216 patients with 216 lesions who underwent optical coherence tomography (OCT) before interventional procedure for late drug-eluting stent ISR were enrolled and divided into NA and non-NA groups based on OCT findings. Results showed that higher LDL-C levels were associated with NA, thin-cap fibroatheroma (TCFA), intimal disruption, plaque erosion, and thrombosis. Multivariate regression analysis revealed that the LDL-C level was an independent risk factor for NA and TCFA. The LDL-C levels exhibited a significant predictive value for NA and TCFA, surpassing other factors such as stent age and other lipid types. In conclusion, a high LDL-C level is an independent predictor of NA incidence and plaque vulnerability in patients with late ISR.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of LDL-C level with neoatherosclerosis and plaque vulnerability in patients with late restenosis: an optical coherence tomography study

Liu,

Deng,

Zhao

et al. 2023

Int J Cardiovasc Imaging

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“…Hypertriglyceridemia is considered an independent risk factor of ISR after PCI [ 107 ]; non-fasting hypertriglyceridemia is a residual risk factor after statin therapy, and lipoproteins rich in triglyceride are considered to result in intimal cholesterol deposition, NA, pro-inflammation and apoptosis [ 108 ]. Serum low-density lipoprotein cholesterol concentrations have received more attention in NA.…”

Section: Progress In the Treatment And Prevention Of Namentioning

confidence: 99%

Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent Failure

Jiang,

Zhang,

Han

et al. 2024

Rev. Cardiovasc. Med.

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With the development of drug-eluting stents, intimal re-endothelialisation is significantly inhibited by antiproliferative drugs, and stent restenosis transforms from smooth muscle cell proliferation to neoatherosclerosis (NA). As a result of the development of intravascular imaging technology, the incidence and characteristics of NA can be explored in vivo , with some progress made in illustrating the mechanisms of NA. Experimental studies have shed light on the molecular characteristics of NA. More critically, sufficient evidence proves NA as a significant cause of late stent failure. Treatments for NA are still being explored. In this review, we summarise the histopathological characteristics of different types of stent NA, explore the potential relationship of NA with native atherosclerosis and discuss the clinical significance of NA in late stent failure and the promising present and future prevention and treatment strategies.

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Lipid profile and risk factors for neoatherosclerosis after drug-eluting stent implantation in acute coronary syndrome

Nakamura,

Sakai,

Torii

et al. 2024

Journal of Clinical Lipidology

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Impact of triglyceride-rich lipoproteins on early in-stent neoatherosclerosis formation in patients undergoing statin treatment

Cited by 5 publications

References 40 publications

Association of LDL-C level with neoatherosclerosis and plaque vulnerability in patients with late restenosis: an optical coherence tomography study

Association of LDL-C level with neoatherosclerosis and plaque vulnerability in patients with late restenosis: an optical coherence tomography study

Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent Failure

Lipid profile and risk factors for neoatherosclerosis after drug-eluting stent implantation in acute coronary syndrome

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