Impact of TT virus infection in acute and chronic, viral- and non viral-related liver diseases

Tuveri, Rosella; Jaffredo, Franck; Lunel, F.; Nalpas, Bertrand; Pol, Stanislas; Féray, Cyrille; Marcellin, Patrick; Thibault, Vincent; Delagneau, J.F.; Opolon, P; Scarpa, B; Bréchot, Christian; Thiers, Valérie

doi:10.1016/s0168-8278(00)80168-3

Cited by 30 publications

(24 citation statements)

References 23 publications

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“…25,26 It is unclear whether TTV is efficiently transmitted by sexual intercourse but recent data obtained in France suggest that this is the case. 42 Most studies on TTV in North America and Europe have shown no significant impact of TTV on liver disease. However, a few studies have suggested an association with acute and chronic hepatitis and TTV and HCC.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Tuveri¹,

Perret²,

Delaporte³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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Abstract. The distribution of Hepatitis GB-C/HG (GB-C/HG) and TT viruses (TTV) infections was investigated in selected populations from Gabon using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) for anti-Envelop 2 (anti-E2) GBV-C/HGV antibodies. Among pregnant women, 29 of 229 (12.6%) were Hepatitis GB virus-C and Hepatitis G virus (GBV-C/ HGV) RNA positive (ϩ) and 32 of 81 (39.5%) anti-E2 ϩ versus 8 of 39 (20.5%) TTV DNA ϩ. Among sickle cell anemia patients, 9.7% (3/31) were GBV-C/HGV RNA ϩ versus 22.5% (7/31) TTV DNA ϩ. For tuberculosis patients, the figures were 11.5% (4/35) and 0%. A study of hepatocellular carcinoma cases (n ϭ 27) versus controls (n ϭ 66) did not show significant differences for GBV-C/ HGV RNA (10.7% versus 12.1%) and TTV DNA (44.4% versus 30.3%). According to phylogenetic analysis, the 15 GBV-C/HGV strains investigated clustered in group 1, the most common in sub-Saharan Africa whereas TTV sequences (n ϭ 4) mostly clustered in genotypes G1 and one close to genotype G3. In the Gabonese populations investigated, GBV-C/HGV and TTV infections were highly endemic. These data are consistent with the low pathogenicity of these agents.

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Section: Discussionmentioning

confidence: 99%

Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Tuveri¹,

Perret²,

Delaporte³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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“…Not only the clinical significance and the pathogenesis of TTV infection but also the association between T T V i n f e c t i o n a n d r a i s e d A LT va l u e s h ave b e e n controversial [1,3,113] . It was found that the raised ALT values were independently related to TTV viraemia among Taiwanese who were not infected with HBV and HCV.…”

Section: Ttv Coinfectionmentioning

confidence: 99%

“…TTV infection seemed to be responsible for raised ALT values and to hint positive hepatopathic effects. Tuveri et al suggested that TTV might be implicated in a few cases of acute and chronic non A-non G hepatitis [113] . However, Nakano et al reported that TTV was not the main causative agent of cryptogenic liver disease [114] .…”

Section: Ttv Coinfectionmentioning

confidence: 99%

Transfusion transmitted virus: A review on its molecular characteristics and role in medicine

Irshad¹,

Yk²,

Dhar³

2006

WJG

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The present review gives an updated overview of transfusion transmitted virus (TTV), a novel agent, in relation to its molecular characteristics, epidemiological features, modes of transmission, tissue tropism, pathogenesis, role in various diseases and its eradication from the body. TTV, a DNA virus, is a single stranded, non-enveloped, 3.8 kb long DNA virus with a small and covalently closed circular genome comprising 3852 bases. It was tentatively designated Circinoviridae virus.TTV genome sequence is heterogeneous and reveals the existence of six different genotypes and several subtypes. TTV has been reported to transmit not only via parenteral routes, but also via alternate routes. This virus has been detected in different non-human primates as well. At present, TTV is detected by polymerase chain reaction (PCR) with no other available diagnostic assays. It shows its presence globally and was detected in high percent populations of healthy persons as well as in various disease groups. Initially it was supposed to have strong association with liver disease; however, there is little evidence to show its liver tropism and contribution in causing liver diseases. It shows high prevalence in hemodialysis patients, pointing towards its significance in renal diseases. In addition, TTV is associated with several infectious and non-infectious diseases. Although its exact pathogenesis is not yet clear, TTV virus possibly resides and multiplies in bone marrow cells and peripheral blood mononuclear cells (PBMCs). Recently, attempts have been made to eradicate this virus with interferon treatment. More information is still needed to extricate various mysteries related to TTV.

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“…However, the evidence is not totally unequivocal, since data also exist that are compatible with the possibility that, in some cases, transient and mild abnormalities in liver enzyme levels are associated with TTV infection (33,34,56,61,65,68,81,88,110,126). Likewise, in several series of HCV patients, coinfection with TTV appeared to be associated with increased severity of biochemical and histological parameters of liver damage (15,22,48,56,172,175,191). In a series of 26 patients with fulminant liver failure studied by Tanaka et al (163), mortality was 100% in TTV-infected patients versus less than 50% in uninfected ones.…”

Section: Clinical Significancementioning

confidence: 99%

Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans

et al. 2001

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TT virus (TTV) was first described in 1997 by representational difference analysis of sera from non-A to non-G posttransfusion hepatitis patients and hence intensively investigated as a possible addition to the list of hepatitis-inducing viruses. The TTV genome is a covalently closed single-stranded DNA of approximately 3.8 kb with a number of characteristics typical of animal circoviruses, especially the chicken anemia virus. TTV is genetically highly heterogeneous, which has led investigators to group isolates into numerous genotypes and subtypes and has limited the sensitivity of many PCR assays used for virus detection. The most remarkable feature of TTV is the extraordinarily high prevalence of chronic viremia in apparently healthy people, up to nearly 100% in some countries. The original hypothesis that it might be an important cause of cryptogenic hepatitis has not been borne out, although the possibility that it may produce liver damage under specific circumstances has not been excluded. The virus has not yet been etiologically linked to any other human disease. Thus, TTV should be considered an orphan virus

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Impact of TT virus infection in acute and chronic, viral- and non viral-related liver diseases

Cited by 30 publications

References 23 publications

Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Transfusion transmitted virus: A review on its molecular characteristics and role in medicine

Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans

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