Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

Zhu, Yue; Liu, Haichao; Xie, Ning; Liu, Xiqiang; Huang, Hongzhang; Wang, Cheng; Hou, Jinsong

doi:10.1002/hed.25462

Cited by 52 publications

(54 citation statements)

References 56 publications

(128 reference statements)

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“…Previously, we and other researchers found that tumor budding was correlated with lymph node metastasis and poor survival according to assessment method reported by Ueno . Importantly, meta‐analyses also revealed that high tumor budding scores indicated a poor prognosis in head and neck squamous cell carcinoma and oral squamous cell carcinoma . In this study, similar results were observed in an OTSCC patient cohort based on the ITBCC scoring system.…”

Section: Discussionsupporting

confidence: 85%

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Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma

Xie

Liu

et al. 2019

J Oral Pathology Medicine

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Background Tumor budding is a valuable prognostic marker in oral tongue squamous cell carcinoma (OTSCC) but lacks a standardized scoring system. The aim of this study was to evaluate the prognostic value of tumor budding for OTSCC patients based on the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016. Methods Tumor budding was scored as ITBCC recommended in 255 patients with OTSCC. Then, associations between tumor budding and clinicopathologic parameters were examined. Among them, 136 patients with follow‐up data available were used to evaluate overall survival (OS) by the Kaplan‐Meier method. Prognostic value of tumor budding was assessed by Cox regression analysis. The inter‐observer and intra‐observer agreement was calculated by the kappa statistic. Results Tumor budding score was associated with lymph node metastasis, differentiation, invasive pattern, lymphoid infiltrate, tumor relapse, invasive depth, and reduced OS in OTSCC patients. The Cox analysis showed high budding score was an independent prognostic factor in patients with all clinical stage and patients with clinical early‐stage OTSCC. The high kappa values were achieved in intra‐observer and inter‐observer. Conclusions International Tumor Budding Consensus Conference scoring system is a simple, reliable, and reproducible method to measure tumor budding in OTSCC, which should be included in the routine pathological report.

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Section: Discussionsupporting

confidence: 85%

“…Accumulating evidences have implicated tumor budding as a strong and valuable independent prognostic factor in many solid cancers . Moreover, evaluation of tumor budding in biopsy specimens also might provide useful prognostic information, indicating a promising clinical application for patient diagnosis and treatment .…”

Section: Discussionmentioning

confidence: 99%

Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma

Xie

Liu

et al. 2019

J Oral Pathology Medicine

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“…the correlation of NLM with TBG, but they were limited to high TBG cases (13,14). In our previous study (15), we found that TBG is the most important prognostic factor for the early T-stage tongue SCC.…”

Section: Podoplanin Is An Efficient Predictor Of Neck Lymph Node Metamentioning

confidence: 81%

Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade

et al. 2020

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The current study investigated the efficacy of podoplanin expression in tumor budding cells as a predictor of neck lymph node metastasis (NLM) in patients with tongue squamous cell carcinoma (SCC) of low tumor budding grade (TBG). A total of 99 patients with early T-stage tongue SCC of any clinical N status who received the initial curative treatment were enrolled. The association between podoplanin expression and NLM was immunohistochemically analyzed, with a focus on tongue SCC with low TBG. The disease-specific survival (DSS) rate was 77% at 5 years, and a significant difference was observed between the NLM-positive and NLM-negative groups, and between the low (n=77) and high (n=22) TBG groups. In the low TBG group, there was a significant difference in DSS between the NLM-positive and NLM-negative groups. The multivariate analysis showed that lymphatic vessel invasion (ly) [odds ratio (OR)=11.5, 95% confidence interval (CI): 1.50-87.6; P=0.02] and podoplanin expression (OR=7.07, 95% CI: 1.80-27.7; P=0.005) were significantly correlated with NLM. Furthermore, negative predictive values (NPV) of ly and podoplanin expression for NLM were 75% and 88%, respectively. Considering the balance of stratification case number adding to ratio, NLM-negative prediction by podoplanin was more significant than that by ly for the low TBG group. The results of the present study demonstrated that podoplanin expression in tumor budding is an independent and efficient predictor of NLM in the tongue SCC with low TBG. The low TBG and podoplanin-negative cases may be candidates for the wait and watch policy, therefore, reducing inappropriate elective neck lymph node dissections.

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“…Scoring of tumor budding is cost-effective and many studies on tumor budding have followed the guidelines for reporting recommendations for tumor marker prognostic studies (REMARK). 33 In laryngeal cancer, Sarioglu et al 8 were the first to evaluate tumor budding in HNSCC and they reported the prognostic power of tumor budding to predict distant metastasis in laryngeal carcinoma. Of note, our recent systematic search found 16 studies on tumor budding in OSCC and the meta-analysis confirmed the significance of tumor budding in prognostication of lymph node metastasis and survival.…”

Section: Tumor Budding As a Simple Promising Prognostic Marker In Hmentioning

confidence: 99%

“…10 Subsequently, after that meta-analysis many studies have been published indicating that tumor budding is a promising prognostic marker in OSCC, 21,[29][30][31][32] including the recent meta-analysis with tumors from various subsites of the head and neck. 33 In laryngeal cancer, Sarioglu et al 8 were the first to evaluate tumor budding in HNSCC and they reported the prognostic power of tumor budding to predict distant metastasis in laryngeal carcinoma. More recent studies have confirmed the prognostic value of tumor budding in laryngeal cancer.…”

Section: Tumor Budding As a Simple Promising Prognostic Marker In Hmentioning

confidence: 99%

Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

et al. 2019

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Invasion and metastasis are hallmarks of cancer. The concept of tumor budding at tumor‐host interface has been documented in many carcinomas. A growing body of evidence indicates that tumor budding is a sign of invasion and early step for metastasis of many epithelial cancers including head and neck squamous cell carcinoma (HNSCC). In addition, recent research has underlined the importance of tumor budding as a promising prognosticator in HNSCC. This review summarizes the findings regarding tumor budding in HNSCC and focuses on the role of tumor budding in invasion and metastasis. Also, we highlight the prognostic significance of tumor budding in HNSCC and its potential for improving clinical decision making in terms of recommending optimal individualized treatment for this patient population.

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Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

Cited by 52 publications

References 56 publications

Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma

Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma

Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade

Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

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