Impact of tumor dimensions and lymph node density on the survival of patients with hypopharyngeal squamous cell carcinoma

Abstract

PurposeTo analyze the potential variables affecting the survival of patients undergoing primary surgery for hypopharyngeal squamous cell carcinoma.Patients and methodsBetween August 2007 and December 2016, 93 patients with primary hypopharyngeal squamous cell carcinomas undergoing radical surgery at Fudan University Shanghai Cancer Center were reviewed. The clinicopathological features were analyzed retrospectively. The optimal cutoff values were determined based on the receiver operating characteristic curve analysis. Pearson correlation coefficients were used to assess the correlations between variables. The Kaplan–Meier and Cox proportional hazard methods were used to evaluate the impact of variables on overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS).ResultsCox multivariate analysis revealed that a depth of invasion (DOI) ≥ 4.3 mm was correlated with inferior OS (P=0.045), DSS (P=0.046), and DFS (P=0.046). A primary tumor volume (PTV) ≥0.36 mL was related to poor OS (P=0.018), DSS (P=0.026), and DFS (P=0.036). A lymph node density (LND) ≥0.07 was also associated with worse OS (P=0.014) and DSS (P=0.045). Moreover, additional prognostic value was observed in the combined use of PTV and LND.ConclusionThe DOI, PTV, and LND obtained from the surgical specimens could provide additional valuable information for prognostic stratification and allowed the more appropriate selection of suitable candidates for more aggressive adjuvant therapy.

Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: A systematic review and meta-analysis

“…The mean or median follow-up time of The results of the quality assessment ranged from 4 to 7 (Table 3). Quality scores of 8 studies [14,16,[18][19][20][21][22]27] were more than 5, indicating that most of the studies were moderate quality. [12,15,18,29] explored the association between LNR and OS, DSS, DFS outcomes respectively.…”

“…The outcomes were overall OS, DSS and DFS. OS was defined as the period from surgery to the last follow-up or death [19][20][21][22]. DSS was referred to the period from the initial diagnosis to LHSCC-related or treatment-related death [16,[20][21][22].…”

“…OS was defined as the period from surgery to the last follow-up or death [19][20][21][22]. DSS was referred to the period from the initial diagnosis to LHSCC-related or treatment-related death [16,[20][21][22]. DFS was defined as the period from the surgery to the last follow-up with no evidence of recurrence or distant metastasis [19,21,22].…”

Prognostic value of lymph node density on Cancer Staging System for non-metastatic gastric cancer: a population-based analysis of SEER database

“…With the development of surgical techniques, obtaining and examining an increasing number of total regional nodes is no longer di cult for an experienced surgeon. Lymph node density (LND), also called lymph node ratio (LNR), is calculated by the ratio of the number of positive nodes to the total examined nodes [12,13]. This parameter has been proven as a potential prognostic factor in several cancers, including GC [14][15][16].…”

Molecular Markers of MDR of Chemotherapy for HSCC: Proteomic Screening With High-Throughput Liquid Chromatography-Tandem Mass Spectrometry

“…These characteristics pose a considerable treatment challenge and make HSCC a major lifethreatening illness. The 5-year overall survival of HSCC is only 30%-35% (3)(4)(5).…”