Impact of Two Different Anesthetic Techniques on Immune Response and Postoperative Pain for Abdominal Hysterectomy

Ashrey, Enas M; Bosat, Bosat Elwany

doi:10.21608/mjcu.2019.78253

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…We suggested that the use of SA for cesarean section in preeclampsia patients may slow the increase in cytokines after surgery. Contradictory to our results, Mohammed Ashery et al (17) showed that at 30 minutes after anesthesia induction and at four hours postoperatively, the levels of IL-6 and TNF were significantly higher in the SA group compared to the GA group in benign abdominal hysterectomy. The level of anti-inflammatory IL-10 also significantly increased in the GA group at four hours after surgery as compared to the SA group.…”

Section: Discussionsupporting

confidence: 76%

“…We did not find any significant difference in the concentration of IL-10; also, no significant difference was found in the ratio of IL-6 changes to IL-10 changes or TNF-α changes to IL-10 changes between the two groups. The reason may be that the IL-10 level usually rises hours after the operation, while we measured postoperative cytokines only 30 minutes after surgery (12,17). Interestingly, Malamitsi-Puchner et al (15) found that b There was a significant difference between the groups.…”

Section: Discussionmentioning

confidence: 90%

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Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial

et al. 2021

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Background: Tissue damage caused by major surgery, such as cesarean section, may lead to a poor host immune response and excessive release of cytokines. These responses may increase the risk of infection, cause postoperative pain, and exert damaging effects on various body organs. Objectives: Anesthesia methods may affect cytokine production after surgery. This study aimed to compare the serum levels of cytokines in general and spinal anesthesia among women undergoing cesarean section. Methods: Thirty parturients (ASA class I and II) undergoing cesarean section were randomly assigned into two equal groups of spinal anesthesia and general anesthesia. Blood samples were taken for measuring the levels of interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) before induction of anesthesia and 30 minutes after entering the recovery room. Results: In the general anesthesia group, the postoperative serum levels of IL-6 and TNF-α were significantly higher than the corresponding preoperative levels. Significant differences were found between the two groups in the preoperative and postoperative levels of TNF-α. Changes in the IL-6 and TNF-α concentrations were significantly higher in the general anesthesia group as compared to the spinal anesthesia group. However, there was no significant difference in the IL-6:IL-10 and TNF-α: IL-10 ratios between the two groups. Conclusions: General anesthesia, as compared to spinal anesthesia, significantly increased the IL-6 and TNF-α levels after cesarean section. Therefore, the spinal anesthesia technique may be a better option for patients undergoing cesarean section.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 90%

Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial

et al. 2021

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Immune Responses of Healthy Pregnant Women following an Elective Cesarean Section: Effects of Anesthetic Procedures

Novac,

Boldeanu,

Dijmărescu

et al. 2024

Diagnostics

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A weakened immune system and more inflammatory cytokines being released are possible effects of the surgical stress that a cesarean section induces. This kind of reaction, in addition to the altered reaction to catecholamines, has the potential to significantly affect the immune system of the mother and the patients’ general postoperative course. This prospective study compared the plasma levels of catecholamines and cytokines in healthy pregnant patients having cesarean sections under spinal anesthesia versus general anesthesia. A total of 30 pregnant women undergoing elective cesarean sections were divided into two groups: 15 who received general anesthesia (GA) and 15 who received spinal anesthesia (SA). Blood samples were collected from all subjects before anesthesia induction (pre-OP), 6 h postoperatively (6 h post-OP), and 12 h (12 h post-OP), to measure levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), IL-8, IL-4, IL-10, norepinephrine (NE), and epinephrine (EPI). When we compared the two groups, we discovered that only IL-6 and IL-4 had significantly higher levels pre-OP, whereas all studied cytokines exhibited an increase in the GA versus SA group at 6 and 12 h post-OP. In the case of catecholamines, we discovered that serum levels are positively related with pro-inflammatory or anti-inflammatory cytokines, depending on the time of day and type of anesthetic drugs. Compared to SA, GA has a more consistent effect on the inflammatory response and catecholamine levels. The findings of this study confirm that the type of anesthesia can alter postoperative immunomodulation to various degrees via changes in cytokine and catecholamine production. SA could be a preferable choice for cesarean section because it is an anesthetic method that reduces perioperative stress and allows for less opioid administration, impacting cytokine production with proper immunomodulation.

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Impact of Two Different Anesthetic Techniques on Immune Response and Postoperative Pain for Abdominal Hysterectomy

Abstract: Background: Spinal anesthesia is a famous technique used for lower abdominal surgery, however when it is contraindicated, general anesthesia can be used.

Cited by 2 publications

References 11 publications

Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial

Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial

Immune Responses of Healthy Pregnant Women following an Elective Cesarean Section: Effects of Anesthetic Procedures

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