Impact of uric acid levels on the risk of long-term cardiovascular mortality in patients with type 2 diabetes mellitus

Ilundain-González, Ana Isabel; Gimeno-Orna, José Antonio; Sáenz-Abad, D.; Pons-Dolset, Jordi; Hoyo, Jesús Cebollada-del; Lahoza-Pérez, María del Carmen

doi:10.1016/j.endien.2018.01.005

Cited by 6 publications

(6 citation statements)

References 21 publications

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“…Hyperuricemia was also observed to be associated with an increased incidence of atrial fibrillation in hospitalized patients with T2DM [59]. Hyperuricemia can increase the risk of sudden atrial fibrillation by approximately four-fold [60] and is associated with cardiovascular mortality [61]. Cardiovascular and cerebrovascular diseases are mainly caused by ischemia and hypoxia resulting from coronary atherosclerosis.…”

Section: Epidemiology Studiesmentioning

confidence: 99%

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Xiong

Liu

2019

International Journal of Endocrinology

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With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through inflammation, oxidative stress, vascular endothelial injury, and so on and thus subsequently promotes the occurrence and development of diseases. This review confirmed the positive correlation between uric acid and diabetes mellitus and its chronic complications through the pathogenesis and clinical studies aspects.

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Section: Epidemiology Studiesmentioning

confidence: 99%

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Xiong

Liu

2019

International Journal of Endocrinology

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“… 7 The prevalence of hyperuricemia in the general population has been estimated between 19% and 25%, with higher in males than females in the majority of reports. 8 , 9 Hyperuricemia has been linked to increased risk of cardiovascular events and mortality, 10 and chronic kidney disease development and progression. 11 Additionally, hyperuricemia has been associated with several medical and metabolic conditions, including the different components of the metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Risk Predictors of High Uric Acid Levels Among Patients with Type-2 Diabetes

Eljaaly¹,

Mujammami²,

Nawaz³

et al. 2021

DMSO

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Objective Patients with diabetes are at higher risk of the negative consequences of hyperuricemia. The objective of this study was to investigate gender and age-specific differences in the uric acid levels and to evaluate the associated risk factors among patients with diabetes. Methods A retrospective cross-sectional study was conducted at Strategic Center for Diabetes Research from September 2019 to January 2020, among adult type-2 diabetic patients. Serum uric acid (SUA) and several other metabolic and clinical parameters were examined. Multiple regression analysis was done to identify risk factors independently associated with hyperuricemia. Results A total of 433 patients were included in the analysis. SUA level was higher in males than females (5.82±1.65 mg/dL versus 5.29±1.54 mg/dL, p < 0.001). The prevalence of hyperuricemia was higher in females than males (28.8% versus 20.5%, p = 0.049). There was no significant difference in uric acid levels or the prevalence of hyperuricemia by age groups in the total sample or gender-stratified samples. In multivariate analysis, hyperuricemia was associated with bigger hip circumference (odds ratios [OR] were 1.03, 95% CI = 1.01–1.05), higher triglycerides (OR = 1.005, 95% CI = 1.002–1.008), and higher serum creatinine (OR = 1.34, 95% CI = 1.21–1.49). Hip circumference, total cholesterol, high-density lipoprotein, and serum creatinine were independent risk factors in males, while triglycerides and higher serum creatinine were independent risk factors among females. Conclusion The present study demonstrates gender-specific differences in the uric acid levels and hyperuricemia prevalence. In males and females, hyperuricemia was associated with hip circumference, total cholesterol, high-density lipoprotein, triglycerides, and serum creatinine. Future large studies are needed to confirm our findings, especially in elderly females.

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“…Hyperuricemia is associated with gout, non‐alcoholic fatty liver disease, cardiovascular events and diabetes mellitus . It also increases the risk of mortality in several pathologic conditions such as diabetes mellitus and chronic kidney disease (CKD) . Recent studies have shown that hyperuricemia is a risk factor for postoperative AKI in certain conditions such as heart valve replacement and elective coronary artery bypass graft surgery .…”

mentioning

confidence: 99%

“…7-11 It also increases the risk of mortality in several pathologic conditions such as diabetes mellitus and chronic kidney disease (CKD). [12][13][14] Recent studies have shown that hyperuricemia is a risk factor for postoperative…”

mentioning

confidence: 99%

Hyperuricemia is associated with acute kidney injury and all‐cause mortality in hospitalized patients

et al. 2019

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Aim Hyperuricemia is a risk factor for high morbidity and mortality in several diseases. However, the relationship between uric acid (UA) and the risk of acute kidney injury (AKI) and mortality remain unresolved in hospitalized patients. Methods Data from 18 444 hospitalized patients were retrospectively reviewed. The odds ratio (OR) for AKI and the hazard ratio (HR) for all‐cause mortality were calculated based on the UA quartiles after adjustment for multiple variables. All analyses were performed after stratification by sex. Results The fourth quartile group (male, UA > 6.7 mg/dL; female, UA > 5.4 mg/dL) showed a higher risk of AKI compared with the first quartile group (male, UA < 4.5 mg/dL; female, UA < 3.6 mg/dL), with the following OR: 3.2 (2.55–4.10) in males (P < 0.001); and 3.1 (2.40–4.19) in females (P < 0.001). There were more patients who did not recover from AKI in the fourth quartile compared with the first quartile, with the following OR: 2.0 (1.32–3.04) in males (P = 0.001) and 2.4 (1.43–3.96) in females (P = 0.001). The fourth quartile group had a higher risk of all‐cause mortality compared with the first quartile group, with the following HR: 1.4 (1.20–1.58) in males (P < 0.001) and 1.2 (1.03–1.46) in females (P = 0.019). The in‐hospital mortality risk was also higher in the fourth quartile compared with the first quartile, which was significant only in males (OR, 2.1 (1.33–3.31) (P = 0.002)). Conclusion Hyperuricemia increases the risks of AKI and all‐cause mortality in hospitalized patients.

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Impact of uric acid levels on the risk of long-term cardiovascular mortality in patients with type 2 diabetes mellitus

Cited by 6 publications

References 21 publications

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Risk Predictors of High Uric Acid Levels Among Patients with Type-2 Diabetes

Hyperuricemia is associated with acute kidney injury and all‐cause mortality in hospitalized patients

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