Impact of vaccinating boys and men against HPV in the United States

Elbasha, Elamin H.; Dasbach, Erik J.

doi:10.1016/j.vaccine.2010.08.030

Cited by 204 publications

(222 citation statements)

References 29 publications

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“…[1][2][3][4][5][6][7][8][9][10] Consistent with health benefits estimated by these models, evaluations of vaccination programs have provided a growing body of evidence that documents the initial effects of HPV vaccination on the prevalence of HPV vaccine types, genital warts, and cervical precancers in the US and around the world. [11][12][13][14][15][16][17][18] In the future, more substantial reductions in these outcomes are expected, along with reductions in cervical cancer and other HPV-associated cancers.…”

Section: Introductionmentioning

confidence: 80%

“…[11][12][13][14][15][16][17][18] In the future, more substantial reductions in these outcomes are expected, along with reductions in cervical cancer and other HPV-associated cancers. [5][6][7][8][9][10]13,19 The first 2 HPV vaccines licensed in the US were the bivalent vaccine (2vHPV, which targets HPV types 16 and 18) and the quadrivalent vaccine (4vHPV, which targets HPV types 6, 11, 16, and 18). HPV types 16 and 18 account for 66% of cervical cancer, the majority of anal, oropharyngeal, and vaginal cancers (79%, 60%, and 55%, respectively), and a substantial portion of penile and vulvar cancers (48% and 49%, respectively) in the US.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The impact and cost-effectiveness of nonavalent HPV vaccination in the United States: Estimates from a simplified transmission model

Chesson

Markowitz

Hariri

et al. 2016

Human Vaccines & Immunotherapeutics

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Introduction: The objective of this study was to assess the incremental costs and benefits of the 9-valent HPV vaccine (9vHPV) compared with the quadrivalent HPV vaccine (4vHPV). Like 4vHPV, 9vHPV protects against HPV types 6, 11, 16, and 18. 9vHPV also protects against 5 additional HPV types 31, 33, 45, 52, and 58. Methods: We adapted a previously published model of the impact and cost-effectiveness of 4vHPV to include the 5 additional HPV types in 9vHPV. The vaccine strategies we examined were (1) 4vHPV for males and females; (2) 9vHPV for females and 4vHPV for males; and (3) 9vHPV for males and females. In the base case, 9vHPV cost $13 more per dose than 4vHPV, based on available vaccine price information. Results: Providing 9vHPV to females compared with 4vHPV for females (assuming 4vHPV for males in both scenarios) was cost-saving regardless of whether or not cross-protection for 4vHPV was assumed. The cost per quality-adjusted life year (QALY) gained by 9vHPV for both sexes (compared with 4vHPV for both sexes) was < $0 (cost-saving) when assuming no cross-protection for 4vHPV and $8,600 when assuming cross-protection for 4vHPV. Conclusions: Compared with a vaccination program of 4vHPV for both sexes, a vaccination program of 9vHPV for both sexes can improve health outcomes and can be cost-saving.

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Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

The impact and cost-effectiveness of nonavalent HPV vaccination in the United States: Estimates from a simplified transmission model

Chesson

Markowitz

Hariri

et al. 2016

Human Vaccines & Immunotherapeutics

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“…19 Studies in a number of countries had demonstrated that an extension of the current HPV program to include both boys and girls is a cost effective preventive intervention that would lead to a faster prevention of cancers, cancer precursors and genital warts in men and women. [20][21][22] A high coverage in both genders will help achieve herd immunity and largely eradicate this virus.…”

Section: Discussionmentioning

confidence: 99%

“…5 The quadrivalent vaccine (Gardasil) covers HPV 6,11,16 and 18. It is efficacious in preventing many of the above mentioned morbidities in both men and women. For example, Gardasil was efficacious to prevent nearly 100% of cervical cancers among women aged [18][19][20][21][22][23][24]6 90% of genital lesions among heterosexual men aged [16][17][18][19][20][21][22][23][24][25][26]7 78% of ano-genital warts and 75% of anal intraepithelial neoplasia among MSM. 8 Its safety was also warranted in above-mentioned populations.…”

Section: Introductionmentioning

confidence: 99%

How university students view human papillomavirus (HPV) vaccination: A cross-sectional study in Jinan, China

Zou

Wang

et al. 2015

Human Vaccines & Immunotherapeutics

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The acceptability of HPV vaccination among university students in China is not well understood. Our study was of cross-sectional study design. We collected a questionnaire about socio-demographic characteristics, knowledge of, attitude toward and acceptability of HPV vaccination. A total of 351 students were included in data analyses, among whom 47.6% were males and 70.0% aged 19-21. Only 10.3% had previously heard of HPV and 5.4% HPV vaccine. Male and female students were equally likely to accept HPV vaccine (71.8 vs 69.4%, p D 0.634) and recommend it to sexual partners (73.1 vs 76.7%, p D 0.441). The great majority of students could only afford RMB 300 (USD 50) or less for HPV vaccination. HPV vaccination acceptance was associated with being in year-one (Adjusted odds ratio (AOR) D 3.78, 95% confidence interval (CI): 2.12-6.75), being from a key university (AOR D 1.88, 95%CI: 1.07-3.31), having heard of HPV-related morbidities (AOR D 1.88, 95% CI: 1.05-3.35), being concerned about HPV-related morbidities (AOR D 2.23, 95% CI: 1.16-4.27) and believing the vaccine should be given before first sexual contact (AOR D 2.44, 95% CI: 1.38-4.29). Female students were more likely to anticipate a late uptake of HPV vaccination (p D 0.002). The relatively lower levels of HPV knowledge but higher levels of vaccine acceptance among undergraduates highlighted the need for education on the roles of sexual behaviors in HPV transmission.

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“…The understanding of HPV infection and associated diseases in men has increasing importance due to advent of highly efficacious HPV prophylactic vaccines and possibility that the same vaccines may be also useful in preventing HPV infection in men. (Palefsky, 2010., Elbasha & Dasbach, 2010. Also, the impact of HPV vaccination in women, on male anogenital HPV infection needs to be assessed as well.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Infection in Croatian Men: Prevalence and HPV Type Distribution

Grahovac¹,

Dorić²,

Hruškar³

et al. 2012

Sexually Transmitted Infections

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Impact of vaccinating boys and men against HPV in the United States

Cited by 204 publications

References 29 publications

The impact and cost-effectiveness of nonavalent HPV vaccination in the United States: Estimates from a simplified transmission model

The impact and cost-effectiveness of nonavalent HPV vaccination in the United States: Estimates from a simplified transmission model

How university students view human papillomavirus (HPV) vaccination: A cross-sectional study in Jinan, China

Human Papillomavirus Infection in Croatian Men: Prevalence and HPV Type Distribution

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