“…However, in the presence of inherited thrombophilia and absence of venous thrombosis, long term anticoagulants or antiplatelet therapy is recommended (Class IIa) [47]. Recently a sub group analysis of the Warfarin Aspirin Recurrent Stroke Study (WARSS) failed to document any benefit of anticoagulation over aspirin in patients with aortic valve sclerosis [48]. Anticoagulation has no effect on spontaneous calcific embolism, but may be useful to prevent microthrombus formation.…”