Impact of Venous Tumour Thrombus Consistency (Solid vs Friable) on Cancer-specific Survival in Patients with Renal Cell Carcinoma

Bertini, Roberto; Roscigno, Marco; Freschi, Massimo; Strada, E.; Angiolilli, D.; Petralia, Giovanni; Matloob, Rayan; Sozzi, Francesco; Capitanio, Umberto; Pozzo, L. Da; Colombo, Renzo; Guazzoni, G.; Cremonini, Anna Laura; Montorsi, Francesco; Rigatti, Patrìzio

doi:10.1016/j.eururo.2011.05.029

Cited by 49 publications

(83 citation statements)

References 18 publications

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“…При этом возможен отрыв тромба, что относит-ся к очень серьезным осложнениям. Одним из главных критериев, определяющих риск отрыва тромба во вре-мя операции, является его структура, а именно консис-тенция, которая, по данным литературы, представ-ляется как плотная и рыхлая (в англоязычной литературе соответственно solid и friable), последняя считается неблагоприятным прогностическим факто-ром заболевания [13,14]. Указанные термины относят к гистологической характеристике опухолевого тром-ба, так для плотной консистенции опухолевой массы характерен компактный сцепленный рост клеток, ли-нейный закругленный контур тромба, иногда с эндо-телиальной выстилкой, имитирующей псевдокапсулу.…”

Section: Introductionunclassified

“…Указанные термины относят к гистологической характеристике опухолевого тром-ба, так для плотной консистенции опухолевой массы характерен компактный сцепленный рост клеток, ли-нейный закругленный контур тромба, иногда с эндо-телиальной выстилкой, имитирующей псевдокапсулу. Для рыхлой консистенции характерно расположение опухолевых клеток вперемешку с обильными зонами некроза и тяжистыми отложениями фибрина; сам тромб обычно имеет неровный, фестончатый контур, иногда с наличием выростов по типу сосочков [13]. Такое детальное определение структуры опухолевого тромба по данным гистологического исследования пока не получило достойной оценки и широкого при-менения в рутинной клинической практике.…”

Section: Introductionunclassified

“…Из всех морфологических признаков консистен-ции тромба, представленных в работе R. Bertini [13], по данным методов лучевой диагностики можно пред-полагать лишь наличие или отсутствие в структуре тромба зон некроза. Уверенно высказаться о контуре тромба возможно только в случае его флотации в просвете НПВ [17].…”

Section: Introductionunclassified

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Radiodiagnostic methods in determining the structure of tumor thrombus in the inferior vena cava in kidney cancer

Вихрова¹,

Долгушин²,

Панов³

et al. 2015

Onkourologiya

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Section: Introductionunclassified

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Radiodiagnostic methods in determining the structure of tumor thrombus in the inferior vena cava in kidney cancer

Вихрова¹,

Долгушин²,

Панов³

et al. 2015

Onkourologiya

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“…Where TNM was not clear, the histological slides were reassessed. The morphological aspect of the TT was classified into solid (sTT) or friable (fTT) according to the definition described by Bertini et al [10]. Briefly, in solid TT, tumour growth was defined as compact and cohesive, with a rounded linear profile and an endothelial lining simulating a pseudocapsule (Fig.…”

Section: Pathological Findingsmentioning

confidence: 99%

“…In fact, there have been only three studies in total that have investigated the significance of TT consistency for patients' survival, and they produced rather conflicting results [10,11,12]. To address this vacuum, we analysed the impact of tumour thrombus consistency on patients' survival.…”

Section: Introductionmentioning

confidence: 99%

Tumour thrombus consistency has no impact on survival in patients with renal cell carcinoma

Gołąbek¹,

Przydacz²,

Okoń³

et al. 2016

pjp

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The prognosis of renal cell carcinoma (RCC) with venous tumour thrombus (VTT) is variable and not always possible to predict. The prognostic impact and independence of tumour thrombus-related factors including the recently introduced tumour thrombus consistency (TTC) on overall survival remain controversial. The aim of this study was to investigate the prognostic role of TTC in patients' survival. We determined the tumour thrombus consistency (solid vs. friable) in a cohort of 84 patients with RCC and VTT who underwent nephrectomy with thrombectomy, and performed a retrospective evaluation of the patients' data from the prospectively maintained database. A total of 45% of patients had solid thrombus (sTT) and 55% had friable thrombus (fTT). The venous tumour thrombus consistency was not predictive of overall survival. Further studies, preferably prospective and with a larger number of patients, are needed to validate the obtained results, as well as to evaluate the usefulness of tumour thrombus consistency in clinical practice for stratifying the risk of recurrence and planning further follow-up.

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Intravoxel Incoherent Motion Diffusion‐Weighted MR Imaging and Venous Tumor Thrombus Consistency in Renal Cell Carcinoma

Zhao

Wang

Ding

et al. 2023

Magnetic Resonance Imaging

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BackgroundVenous tumor thrombus (VTT) consistency of renal cell carcinoma (RCC) is an important consideration in nephrectomy plus thrombectomy. However, evaluation of VTT consistency through preoperative MR imaging is lacking.PurposeTo evaluate VTT consistency of RCC through intravoxel incoherent motion‐diffusion weighted imaging (IVIM‐DWI) derived parameters (Dt, Dp, f, and ADC) and the apparent diffusion coefficient (ADC) value.Study TypeRetrospective.PopulationOne hundred and nineteen patients (aged 55.8 ± 11.5 years, 85 male) with histologically‐proven RCC and VTT who underwent radical resection.Field Strength/Sequences3.0‐T; two‐dimensional single‐shot diffusion‐weighted echo planar imaging sequence at 9 b‐values (0–800 s/mm2).AssessmentIVIM parameters and ADC values of the primary tumor and the VTT were calculated. The VTT consistency (friable vs. solid) was determined through intraoperative findings of two urologists. The accuracy of VTT consistency classification based on the individual IVIM parameters of primary tumors and of VTT, and based on models combining parameters, was assessed. Type of operation, intra‐operative blood loss, and operation length were recorded.Statistical TestsShapiro–Wilk test; Mann–Whitney U test; Student's t‐test; Chi‐square test; Receiver operating characteristic (ROC) analysis. Statistical significance level was P < 0.05.ResultsOf the enrolled 119 patients, 33 patients (27.7%) had friable VTT. Patients with friable VTT were significantly more likely to experience open surgery, have significantly more intraoperative blood loss, and significantly longer operative duration. The area under the ROC curve (AUC) values of Dt of the primary tumor and VTT in classifying VTT consistency were 0.758 (95% CI 0.671–0.832) and 0.712 (95% CI 0.622–0.792), respectively. The AUC value of the model combining Dp and Dt of VTT was 0.800 (95% CI 0.717–0.868). Furthermore, the AUC of the model combining Dp and Dt of VTT and Dt of the primary tumor was 0.886 (95% CI 0.814–0.937).ConclusionIVIM‐derived parameters had the potential to predict VTT consistency of RCC.Evidence Level: 3Technical Efficacy: Stage 2

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Impact of Venous Tumour Thrombus Consistency (Solid vs Friable) on Cancer-specific Survival in Patients with Renal Cell Carcinoma

Cited by 49 publications

References 18 publications

Radiodiagnostic methods in determining the structure of tumor thrombus in the inferior vena cava in kidney cancer

Radiodiagnostic methods in determining the structure of tumor thrombus in the inferior vena cava in kidney cancer

Tumour thrombus consistency has no impact on survival in patients with renal cell carcinoma

Intravoxel Incoherent Motion Diffusion‐Weighted MR Imaging and Venous Tumor Thrombus Consistency in Renal Cell Carcinoma

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