The most essential components in escort farming are the determination of airflow patterns and the distribution impact of microclimate temperature variables. The objective of this study is to use Computational Fluid Dynamics (CFD) models to ascertain the aerodynamic and thermal dynamics of protected agricultural greenhouses suitable for cultivation in tropical Northeastern crops of Thailand by defining differences in greenhouse layouts, specifically Gable Roof (GR), Curved Roof (CR), Saw tooth roof (SR), and Double roof (DR). The root means square error (RMSE) indicated that the factor determination of CFD modelling using the standard k−ε turbulence model was satisfactory. In addition, they found that, at a significance level of 0.05, the average temperature in the greenhouses was statistically distinct based on the form of the back of the house and the location of the air input and outflow.