Impact of Ventricular Stroke Work Indices on Mortality in Heart Failure Patients After Percutaneous Mitral Valve Repair

Osteresch, Rico; Diehl, Kathrin; Dierks, Patrick; Schmucker, Johannes; Ammar, Azza Ben; Fach, Andreas; Langer, Harald F.; Eitel, Ingo; Hambrecht, Rainer; Wienbergen, Harm

doi:10.1016/j.amjcard.2021.02.018

Cited by 1 publication

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“…The LVSW and CPO are parameters of overall LV function, but the LVSWM and CPOM represent the performance of unit myocardium or myocardial workload. Previous studies on the LVSW index, CPO index, or peak CPOM quantified with stress echocardiography has displayed important prognostic values of these parameters in cardiovascular disease [35][36][37][38][39][40][41][42]. Thus, it is hoped that this work will stimulate further research on these important measures of LV myocardial performance to improve the accuracy of cardiac function assessment and therefore to optimize clinical decisions in cardiovascular disease.…”

Section: Perspectivesmentioning

confidence: 81%

Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults

Yin

2023

PLoS ONE

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Background Left ventricular stroke work per unit myocardium (LVSWM) and cardiac power output per unit myocardium (CPOM) are important measures of myocardial workload. The sex differences in the myocardial workload and its correlation with blood pressure remain largely unclear. Objectives The purpose of this study is to investigate the sex differences in LVSWM and CPOM, and to relate them to blood pressure in a cohort of apparently healthy adults. Methods The LVSWM and CPOM were estimated in 596 age- and heart rate-matched apparently healthy adults (298 men) using transthoracic echocardiography combined with cuff-measured brachial blood pressure. The data were compared between sexes, and the sex differences in LVSWM and CPOM were related to blood pressure. Results After adjustment for the blood pressure, the LVSWM and CPOM were higher in women than in men [75.0 (73.7–76.4) vs 64.9 (63.5–66.2) cJ/100g for LVSWM, and 912.4 (894.1–930.6) vs 780.2 (762.0–798.5) milliwatt/100g for CPOM, respectively; all P<0.001]. After adjustment for the LVSWM and CPOM, the mean systolic and diastolic blood pressure were 7.4 mm Hg and 5.2 mm Hg higher in men than in women, respectively (all P<0.001). Conclusions For any given blood pressure, the workload per unit myocardium is higher in apparently healthy women than in their male counterparts. A sex-specific definition of normal blood pressure with a relatively lower threshold for women can minimize the sex differences in the myocardial workload, which might reduce the potentially comparatively higher risk of heart failure in women.

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Section: Perspectivesmentioning

confidence: 81%

Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults

Yin

2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

Impact of Ventricular Stroke Work Indices on Mortality in Heart Failure Patients After Percutaneous Mitral Valve Repair

Cited by 1 publication

References 25 publications

Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults

Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults

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