“…During all surgical interventions, the animals were initially sedated with an intramuscular injection of 4% (0.04 g/ml) azaperone (4 mg/kg BW of the minipigs, Stresnil, Jannsen-Cilag, Neuss, Germany), followed by an intramuscular injection of 10% (0.1 g/ml) ketamine (10 mg/kg BW, Bremer Pharma, Warburg, Germany) and 0.5% (5 g/L) midazolam (1.8 mg/kg BW, Braun, Melsungen, Germany). Intubation anesthesia was conducted using Isoflurane (Isofluran CP, CP Pharma GmbH, Burgdorf, Germany) (Mehl et al, 2013). After applying a local anesthetic in the upper and lower jaw (Ultracain DS forte, Hoechst, Frankfurt a. M., Germany), a dental cleaning was performed and all premolars and the first molars were removed.…”