Impact of Very Preterm Birth on Health Care Costs at Five Years of Age

Korvenranta, Emmi; Lehtonen, Liisa; Rautava, Liisi; Häkkinen, Unto; Andersson, Sture; Gissler, Mika; Hallman, Mikko; Leipälä, Jaana; Peltola, Mikko; Tammela, Outi; Linna, Miika

doi:10.1542/peds.2009-2882

Cited by 61 publications

(52 citation statements)

References 20 publications

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“…Research needs to begin at an early stage, particularly in light of the tremendous health care costs generated by the morbidities encountered when prenatal care is limited, and substance dependence is an issue (39,44). The need for gender related medical research is warranted, as sex-specific needs and problems can only be addressed through effective interventions when they have been determined by way of clinical research settings.…”

Section: Resultsmentioning

confidence: 99%

Are Male Neonates More Vulnerable to Neonatal Abstinence Syndrome Than Female Neonates?

et al. 2011

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Objective Prior studies have shown an increased vulnerability among males, to adverse outcomes during the postnatal period. The majority of children exposed to opioids and other medication in utero develop a neonatal abstinence syndrome (NAS), yet individual predisposition for NAS is poorly understood. This investigation examines the role of neonatal sex in the postnatal period, for neonates exposed to standardized opioid maintenance treatment in utero with a focus on the neonatal abstinence syndrome (NAS) regarding severity, medication requirements and duration. Patients and Methods This is a secondary analysis of data collected in a prospective randomized, double-blind, double-dummy multi-center trial examining the comparative safety and efficacy of methadone and buprenorphine during pregnancy (Maternal Opioid Treatment: Human Experimental research MOTHER – study). 131 neonates born to opioid-dependent women randomized at six US sites (n=74) and one European site (n=37) were analyzed. Sex-based differences in birth weight, length, head circumference, NAS duration, NAS severity, and treatment parameters of full-term neonates were assessed. Results Males had a significantly higher birth weight (p=0.027) and head circumference (p=0.017) than females, with no significant sex difference in rates of preterm delivery. No significant sex-related differences were found for NAS development, severity, duration, or medication administered with non significant differences in concomitant drug consumption during pregnancy (p =0.959). Conclusions This unique prospective study shows similar postnatal vulnerability for both sexes, suggesting that factors other than sex are the major determinants of clinically significant NAS.

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Section: Resultsmentioning

confidence: 99%

Are Male Neonates More Vulnerable to Neonatal Abstinence Syndrome Than Female Neonates?

et al. 2011

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“…[5][6][7][8][9][10][11][12][13][14][15][16] Preterm birth and its sequelae can have significant negative psychosocial and financial impacts on families of preterm newborns. [17][18][19][20] While the risks of mortality and morbidity affecting preterm newborns are considerably more frequent at lower gestational ages, 11 late preterm infants (sometimes called 'near-term') still experience significantly higher risks compared with babies born at term. 21 A systematic review of more than 29 million infants (mostly in high-income countries) found that, compared with term birth, late preterm birth was associated with increased 28-day mortality (Risk Ratio (RR) 5.9, 95% CI 5.0 to 6.9) and 1-year mortality (RR 3.7, 95% CI 2.9 to 4.6).…”

Section: Bmj Global Healthmentioning

confidence: 99%

Antenatal corticosteroids for women at risk of imminent preterm birth in low-resource countries: the case for equipoise and the need for efficacy trials

et al. 2017

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The scientific basis for antenatal corticosteroids (ACS) for women at risk of preterm birth has rapidly changed in recent years. Two landmark trials—the Antenatal Corticosteroid Trial and the Antenatal Late Preterm Steroids Trial—have challenged the long-held assumptions on the comparative health benefits and harms regarding the use of ACS for preterm birth across all levels of care and contexts, including resource-limited settings. Researchers, clinicians, programme managers, policymakers and donors working in low-income and middle-income countries now face challenging questions of whether, where and how ACS can be used to optimise outcomes for both women and preterm newborns.In this article, we briefly present an appraisal of the current evidence around ACS, how these findings informed WHO’s current recommendations on ACS use, and the knowledge gaps that have emerged in the light of new trial evidence. Critical considerations in the generalisability of the available evidence demonstrate that a true state of clinical equipoise exists for this treatment option in low-resource settings. An expert group convened by WHO concluded that there is a clear need for more efficacy trials of ACS in these settings to inform clinical practice.

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“…Preterm-born infants, especially if born before 32 wk of gestation, incur substantially high costs for society (4,5). This is not only a major medical problem but a considerable trauma for affected families as well.…”

Section: Introductionmentioning

confidence: 99%

“…However, the causality of this association has not been confirmed. On the other hand, sugar-sweetened (SS) 4 beverages have been linked to obesity and to many adverse health outcomes (20,21). Both obesity (22) and high plasma glucose concentrations (23), even in nondiabetic subjects, are correlated with inflammatory response and preterm delivery.…”

Section: Introductionmentioning

confidence: 99%

Association between intake of artificially sweetened and sugar-sweetened beverages and preterm delivery: a large prospective cohort study

Englund‐Ögge¹,

Brantsæter²,

Haugen³

et al. 2012

The American Journal of Clinical Nutrition

126

102

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Impact of Very Preterm Birth on Health Care Costs at Five Years of Age

Cited by 61 publications

References 20 publications

Are Male Neonates More Vulnerable to Neonatal Abstinence Syndrome Than Female Neonates?

Are Male Neonates More Vulnerable to Neonatal Abstinence Syndrome Than Female Neonates?

Antenatal corticosteroids for women at risk of imminent preterm birth in low-resource countries: the case for equipoise and the need for efficacy trials

Association between intake of artificially sweetened and sugar-sweetened beverages and preterm delivery: a large prospective cohort study

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