Impact of Vessel Mechanical Properties on Hemodynamic Parameters of Blood Flow

Wolański, W.; Gzik-Zroska, Β.; Joszko, Kamil; Kawlewska, E.; Sobkowiak, Marta; Gzik, M.; Kaspera, Wojciech

doi:10.1007/978-3-319-70063-2_29

Cited by 5 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The maximum and minimum deviation was obtained at point P 3 in boundary condition IV (refer to Table 3 ) due to the physiological relevance flow in the presence of the elastic wall. Such a flow condition brought a non-stationary axial velocity profile over the period of time [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Numerical and Experimental Analysis of Shear Stress Influence on Cellular Viability in Serpentine Vascular Channels

et al. 2022

View full text Add to dashboard Cite

3D bioprinting has emerged as a tool for developing in vitro tissue models for studying disease progression and drug development. The objective of the current study was to evaluate the influence of flow driven shear stress on the viability of cultured cells inside the luminal wall of a serpentine network. Fluid–structure interaction was modeled using COMSOL Multiphysics for representing the elasticity of the serpentine wall. Experimental analysis of the serpentine model was performed on the basis of a desirable inlet flow boundary condition for which the most homogeneously distributed wall shear stress had been obtained from numerical study. A blend of Gelatin-methacryloyl (GelMA) and PEGDA200 PhotoInk was used as a bioink for printing the serpentine network, while facilitating cell growth within the pores of the gelatin substrate. Human umbilical vein endothelial cells were seeded into the channels of the network to simulate the blood vessels. A Live-Dead assay was performed over a period of 14 days to observe the cellular viability in the printed vascular channels. It was observed that cell viability increases when the seeded cells were exposed to the evenly distributed shear stresses at an input flow rate of 4.62 mm/min of the culture media, similar to that predicted in the numerical model with the same inlet boundary condition. It leads to recruitment of a large number of focal adhesion point nodes on cellular membrane, emphasizing the influence of such phenomena on promoting cellular morphologies.

show abstract

Section: Discussionmentioning

confidence: 99%

Numerical and Experimental Analysis of Shear Stress Influence on Cellular Viability in Serpentine Vascular Channels

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The model prepared in this way was simulated. The optimal bifurcation angle calculated in the previous simulations was used (Wolański et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

Enhancing Medical Insights Through Computational Fluid Dynamics: Validating Simulation Model for Blood Flow in Vascular System

Ples,

Wolański,

Sobkowiak

2024

Engineering Mechanics

View full text Add to dashboard Cite

Understanding blood flow dynamics within the intricate network of blood vessels is crucial for advancing medical diagnostics and interventions. Computational methods, particularly Computational Fluid Dynamics (CFD), have emerged as powerful tools for studying blood flow behavior, offering invaluable insights into hemodynamic parameters and various physiological conditions. However, the utility of computational simulations in clinical decision-making relies on their accuracy and reliability, necessitating rigorous validation. In this paper, we describe a method of validating shear stress simulation on blood vessel walls by comparing it with a physical erosive model. The parametric arterial model was created in ANSYS, using morphometric parameters obtained from Murray's law. The model was simulated with non-Newtonian blood properties and a constant velocity. A physical model was created using 3D printing and tested under similar flow conditions. Results show agreement between simulated and physical models, confirming the efficacy of computational simulations in understanding vascular physiology and pathology. This underscores the need for continued validation and refinement to maximize their clinical utility.

show abstract

“…Arterial morphometric parameters were obtained using CT of each of the branches were calculated from our database. The optimal bifurcation angle calculated in the previous simulations was used (Sobkowiak et al, 2018;Wolański et al, 2018). The aim of the simulation was to verify the operation of the Murray's law, which tells about maintaining the lowest possible energy during flow.…”

Section: Methodsmentioning

confidence: 99%

Effect of Radius Changes of Middle Cerebral Artery (Mca) on Hemodynamic Parameters

Wolański¹,

Sobkowiak-Pilorz²,

Ples³

et al. 2020

Engineering Mechanics 2020

View full text Add to dashboard Cite

The article describes the study of the influence of the change in the morphometric features of the middle cerebral artery, i.e. inlet and outlet branch diameters on the values of hemodynamic parameters occurring on the arterial wallwall shear stress (WSS) and pressure. For numerical calculations ANSYS CFX software was used. A parametric model of the vessel was developed, based on actual anthropometric MCA measurements of patients. Three optimizations were performed by changing individual radius of the arterial branches. The aim of the study was to verify Murray's law for the lowest stress and pressure values. The optimal bifurcation angle calculated in the previous simulations was used.

show abstract

Impact of Vessel Mechanical Properties on Hemodynamic Parameters of Blood Flow

Cited by 5 publications

References 11 publications

Numerical and Experimental Analysis of Shear Stress Influence on Cellular Viability in Serpentine Vascular Channels

Numerical and Experimental Analysis of Shear Stress Influence on Cellular Viability in Serpentine Vascular Channels

Enhancing Medical Insights Through Computational Fluid Dynamics: Validating Simulation Model for Blood Flow in Vascular System

Effect of Radius Changes of Middle Cerebral Artery (Mca) on Hemodynamic Parameters

Contact Info

Product

Resources

About