Impact of Vitamin D Suplementation in Clinical Outcome at Tuberculosis Spondylitis : Randomized Controlled Trial

Abstract

Mycobacterium tuberculosis (MTB) causes infectious bacterial disease. Most cases of musculoskeletal tuberculosis affect vertebrae which cause spinal tuberculosis (spondylitis), extrapulmonary tuberculosis. Vitamin D deficiency have higher risk in tuberculosis infection. Vitamin D had role in the activation processes on immune cell which eliminate tuberculosis infection. The aim of the study is to assess the impact of oral supplementation of serum vitamin D on clinical outcome in spinal tuberculosis. The study design is randomized controlled trial. Total partisipants is 36 samples. The inclusion criteria were spinal tuberculosis patients diagnosed with MRI and GenExpert. The exclusion criteria were pulmonary tuberculosis, partisipant with other chronic disease such as diabetes, autoimun, malabsorption syndrome. Vitamin D serum levels were measured by ELISA method. There is a significant increasing serum levels of vitamin D in the study group were observed after 4 and 8 supplementation (p< 0.05). On the assessment of ODI and VAS, it decrease significantly in the three groups after 8 weeks of vitamin D supplementation (p<0.05), but in group 10.000 IU also decrease ODI and VAS score significant after 4 weeks supplementation. Trial Registration This study had clinical trial approved by U.S National Library of Medicine (NCT05376189, May 17, 2022).