Impact of Vitamin D Supplementation on Inflammatory Markers’ Levels in Obese Patients

Wiciński, Michał; Ozorowski, Mateusz; Wódkiewicz, Eryk; Otto, Stephan Walter; Kubiak, Karol; Malinowski, Bartosz

doi:10.3390/cimb43030114

Cited by 3 publications

(1 citation statement)

References 108 publications

(109 reference statements)

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“…Vitamin D supplementation increases the levels of anti-inflammatory cytokines (IFN-γ and IL-10) in subjects with normal weight and vitamin D insufficiency [ 134 ]. While some studies have suggested that increased serum 1,25(OH) 2 D 3 concentrations are associated with decreased inflammatory marker expression in individuals with normal weight [ 135 ], other research has found no significant effects of vitamin D on inflammatory biomarkers in patients with obesity [ 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 ]. Furthermore, studies on the effect of vitamin D supplementation on CRP serum levels in patients with obesity have yielded conflicting results [ 137 , 138 , 139 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 ].…”

Section: Resultsmentioning

confidence: 99%

From the Sun to the Cell: Examining Obesity through the Lens of Vitamin D and Inflammation

Popa,

Niță,

Caba

et al. 2023

Metabolites

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Obesity affects more than one billion people worldwide and often leads to cardiometabolic chronic comorbidities. It induces senescence-related alterations in adipose tissue, and senescence is closely linked to obesity. Fully elucidating the pathways through which vitamin D exerts anti-inflammatory effects may improve our understanding of local adipose tissue inflammation and the pathogenesis of metabolic disorders. In this narrative review, we compiled and analyzed the literature from diverse academic sources, focusing on recent developments to provide a comprehensive overview of the effect of vitamin D on inflammation associated with obesity and senescence. The article reveals that the activation of the NF-κB (nuclear factor kappa B subunit 1) and NLRP3 inflammasome (nucleotide-binding domain, leucine-rich-containing, pyrin domain-containing-3) pathways through the toll-like receptors, which increases oxidative stress and cytokine release, is a common mechanism underlying inflammation associated with obesity and senescence, and it discusses the potential beneficial effect of vitamin D in alleviating the development of subclinical inflammation. Investigating the main target cells and pathways of vitamin D action in adipose tissue could help uncover complex mechanisms of obesity and cellular senescence. This review summarizes significant findings related to opportunities for improving metabolic health.

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Section: Resultsmentioning

confidence: 99%

From the Sun to the Cell: Examining Obesity through the Lens of Vitamin D and Inflammation

Popa,

Niță,

Caba

et al. 2023

Metabolites

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Vitamin D3 supplementation shapes the composition of gut microbiota and improves some obesity parameters induced by high-fat diet in mice

Xiang,

Du,

Zhang

et al. 2023

Eur J Nutr

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Effect of Vitamin D Supplementation on Inflammatory Markers in Obese Patients with Acute and Chronic Orthopedic Conditions

Gawryjołek,

Wiciński,

Zabrzyńska

et al. 2024

Nutrients

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Numerous studies have shown that vitamin D may play an important role in modulating the inflammatory process. This study aimed to evaluate the effect of vitamin D supplementation on inflammatory markers in patients with orthopedic disorders and obesity. Thirty-three obese subjects were included in the study and were divided into two groups based on their medical condition: acute orthopedic diseases and chronic orthopedic diseases. Inclusion criteria for the research included age 18–75 years, BMI > 30 kg/m2, vitamin D deficiency, and no previous vitamin D supplementation. Samples were collected before and after 3 months of 4000 IU/day vitamin D supplementation. The study used enzyme-linked immunosorbent assay (ELISA) and measured serum levels of markers such as chitinase-3-like protein 1 (YKL-40), interleukin 6 (IL-6), interleukin 17 (IL-17), tumor necrosis factor (TNF-α), and adiponectin. After 3 months of vitamin D supplementation, a statistically significant increase in vitamin D and IL-17 levels was observed in the group with acute orthopedic diseases. Similarly, after supplementation, a statistically significant increase in vitamin D, IL-6 and TNF-α levels was observed in the group with chronic orthopedic diseases. Moreover, after vitamin D supplementation, statistically significantly higher adiponectin levels were observed in the chronic orthopedic group than in the acute orthopedic group. Despite high-dose vitamin D supplementation, inflammatory markers increased in acute and chronic orthopedic conditions. Based on our study, vitamin D does not reduce inflammation in patients with orthopedic conditions and obesity.

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Impact of Vitamin D Supplementation on Inflammatory Markers’ Levels in Obese Patients

Cited by 3 publications

References 108 publications

From the Sun to the Cell: Examining Obesity through the Lens of Vitamin D and Inflammation

From the Sun to the Cell: Examining Obesity through the Lens of Vitamin D and Inflammation

Vitamin D3 supplementation shapes the composition of gut microbiota and improves some obesity parameters induced by high-fat diet in mice

Effect of Vitamin D Supplementation on Inflammatory Markers in Obese Patients with Acute and Chronic Orthopedic Conditions

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